MHID-3995858PMID: 400369132025Parkinsonism & related disorders
Baltic S, Todorović N, Popovic S, Galic V, Semnic M, Ostojic SM.
Over 10 million individuals worldwide are living with Parkinson's disease (PD), a serious neurodegenerative condition with an unclear etiology. It is widely accepted that PD arises from a complex interplay of genetic and environmental factors, leading to the gradual degeneration of both motor and non-motor systems. Various microbial metabolites and products have been implicated in PD pathology, al
HypothesisOpinion PieceOtherHighlighted
MHID-0628712PMID: 356757612022Annals of Nutrition and Metabolism
Sergej M Ostojic
Molecular hydrogen (dihydrogen or hydrogen gas) is a small bioactive molecule involved in various metabolic pathways, from redox-sensitive reactions and cell signaling to bioenergetics and gut microbiota biology. Drinking hydrogen-rich water (HRW) has been suggested as a safe, novel, and promising nutritional strategy to attenuate metabolic disorders and burdensome and highly prevalent conditions
MHID-8528962PMID: 319024412020The American journal of the medical sciences
Ostojic SM.
Hydrogen medicine has traveled a long and bumpy road. From the very first study published in 1975 in Science to a seminal paper from 2007 from Nature Medicine and many succeeding reports, molecular hydrogen (H2) has been affirmed as a beneficial agent in various pathologies yet still remains outside of conventional healthcare practice. A highly promising therapeutic, hydrogen appears to currently
Opinion Piece
MHID-94117542020Therapeutic Advances in Respiratory Disease
Sergej M Ostojic
Recent public reports by China’s National Health Commission and the Chinese Center for Disease Control and Prevention have recommended effective oxygen therapy measures as an element of general treatment in patients with novel coronavirus pneumonia (COVID-19).1,2 Both documents disclosed a rather exotic ratio of hydrogen and oxygen (66.6% H2 to 33.3% O2) as the composition of the gas mixture for i
HypothesisHighlighted
MHID-3994699PMID: 324455282020Alimentary Pharmacology & Therapeutics
Sergej M Ostojic
EDITORS, I have read with great interest the systematic review with meta- analysis written by Ianiro and co-workers,1 in which the authors have evaluated the efficacy of faecal microbiota transplantation (FMT, or bacteriotherapy) for the treatment of irritable bowel syndrome (IBS). Although only a handful of studies were eligible to be included in this meticulous analysis, the authors implied that
MHID-1362685PMID: 316397972019Annals of nutrition & metabolism
Ostojic SM.
Hydrogen is the simplest, the oldest, and the most abundant element in the Universe; it was originally created about 3 min after the Big Bang, with all the other chemical elements that we know were made up of hydrogen. Being here for such a long time, hydrogen lately appears to find its place in experimental medicine, emerging as an exciting innovative agent that might tackle diabetes and diabetes
Clinical TrialHighlighted
MHID-0517534PMID: 346542212018European Geriatric Medicine
Darinka Korovljev, Valdemar Stajer, Dejan Javorac, Sergej M Ostojic
Molecular hydrogen (H2) has been recently introduced as an experimental medical gas in clinical medicine [1]. Beneficial effects of H2 are attributed to its antioxidant, anti-apoptotic and anti-inflammatory properties, with H2 administered via oral, parenteral or inhalational route found beneficial in cardiometabolic disorders [2]. However, no information is currently available concerning its effi
MHID-9173843PMID: 279654182017Postgraduate medical journal
Ostojic SM.
About 150 years ago, molecular hydrogen (H2) has been identified as a main component of intestinal gas in humans, with subsequent studies detailed its production by coliform bacteria of large intestine as a consequence of food fermentation. Being traditionally recognised as a biologically inert gas, endogenous H2 is either passed in flatus or absorbed by colon mucosa into the circulation and then
Clinical TrialHighlighted
MHID-38265332012Mayo Clinic Proceedings
Sergej M. Ostojic, MD, PhD
Metabolic acidosis is a clinical disturbance characterized by low pH in body tissues and blood and a variety of neuromuscular and cardiorespiratory responses.1 Besides treating the initial disorder, the main goal for patients with acidosis is to increase the systemic pH with alkalizing agents, such as bicarbonates2; however, adverse reactions linked to the administration of sodium bicarbonate (eg,
