Animal StudyIn VitroHighlighted
MHID-5401653PMID: 413343742026Bioactive Materials
Yue Yuan, Zishuo Hou, Miaomiao Chen, Jingwei Yu, Minghao Zhou, Jiaxin Kang, et al.
The weaker soft tissue integration around implants compared to natural teeth poses a substantial challenge to the long-term success of implants. To enhance soft tissue integration, we develop an on-demand and long-lasting H2-releasing implant to achieve precise sequential regulation of the soft tissue integration through immunomodulation and pro-remodeling coupling. In the inflammatory phase, the
Systematic ReviewHighlighted
MHID-43477742026World Journal of Orthopedics
Naveen Jeyaraman, Madhan Jeyaraman, Swaminathan Ramasubramanian, Shrideavi Murugan, Arulkumar Nallakumarasamy, Sathish Muthu
Molecular hydrogen (H2) demonstrates selective antioxidant and anti-inflam-
matory properties with therapeutic potential across musculoskeletal conditions
including osteoarthritis, rheumatoid arthritis, exercise-induced muscle damage,
chronic pain syndromes, tendinopathies, and muscle atrophy. This review
critically evaluates preclinical and clinical evidence for H2 therapy and identifies
research
In VitroHighlighted
MHID-0389345PMID: 415753722026Biochemical Journal
Sabrina Dezzani, Abdulrahman Alogaidi, Anca Pordea, Simone Morra
The production of biofuels by bacterial fermentation receives sustained attention due to the need to develop novel circular and sustainable technologies. Clostridium beijerinckii produces both hydrogen (H2) and carbon-based biofuels acetone, butanol and ethanol (ABE solvents). H2 metabolism in C. beijerinckii is complex and mostly unexplored. Seven hydrogenase genes are contained in the genome, bu
Animal StudyHighlighted
MHID-8967574PMID: 416411602026Frontiers in Nutrition
Eika Mizuno, Tatsuhiro Sato, Kosuke Okada, Ikuru Miura, Junichi Shoda, Makoto Saito, et al.
Introduction: Hydrogen-rich water (HRW) has been reported to reduce oxidative stress, suppress exercise fatigue, and enhance recovery. However, the molecular mechanisms of its effects on exercise capacity, especially during the early stages of adaptation in physically inactive individuals, remain unclear.
Methods: Male 8-week-old C57BL/6 J mice were provided with purified water or HRW for 1, 2, 4,
Observational StudyHighlighted
MHID-67657942026medRxiv
Yuusuke Harada, Michiko Miyakawa
Background: Falls among older adults are a leading cause of fractures, loss of independence, and need for long-term care. Community salons in Japan promote social participation and health activities among older adults. Hydrogen-rich water is widely used as a health product, but evidence in community settings remains limited.
Methods: We conducted a prospective observational study among 48 communit
Animal StudyHighlighted
MHID-6449583PMID: 412075402026Journal of Nutritional Biochemistry
Naomi Kamimura, Katsuya Iuchi, Tsutomu Igarashi, Ikuroh Ohsawa, Chikako Nito, Jitsuo Usuda, et al.
Acetaminophen (APAP) overdose induces severe liver injury, especially in diabetic patients. N -acetylcysteine (NAC) is commonly used as an approved an- tidote for APAP toxicity; however, its narrow therapeutic window limits its clinical utility. This study investigated the protective effects of molecular hydro- gen (H2 ) against APAP-induced hepatotoxicity in diabetic mice. Diabetic db/db mice wer
MHID-9101201PMID: 414893502026The International journal of risk & safety in medicine
Ichikawa Y, Sato B, Takefuji Y, Satoh F.
Background: With the growing recognition of the medical applications of hydrogen, hydrogen gas inhalers are increasingly used in clinics and other healthcare settings. However, hydrogen is highly explosive, and numerous explosion incidents involving these inhalers have been reported.
Objectives: This study evaluates the safety risks of high-concentration hydrogen inhalers (67%-99.99% v/v H2) foll
Animal StudyIn VitroHighlighted
MHID-1663779PMID: 405801852026Medical Gas Research
Yinyin Zhang, Yajing Ying, Xianpeng Zu, Lingling Ding, Xuan Shi, Jing Wang, et al.
Exercise-induced fatigue limits athletic performance. Molecular hydrogen is an effective treatment for relieving fatigue, but the exact mechanism is not clear. In our study, a mouse model of fatigue was established to explore the molecular mechanism by which hydrogen-rich water reduces exercise-induced fatigue. The results showed that hydrogen-rich water improved the motor function of fatigue mice
Animal StudyHighlighted
MHID-1198842PMID: 406436492025Naunyn-Schmiedeberg's Archives of Pharmacology
Muhammed Deniz, Yeliz Akkuş, Gülden Yıldız, Hatice Beşeren Havadar, Mustafa Makav
This study was carried out in an experimental study design with experimental and control groups to investigate the effect of hydrogen-enriched water (HRW) on healing in excisional full-layer skin wounds. The rats were divided into diabetic group (n = 20) and non-diabetic group (n = 18) (n = 38). Diabetic group was divided into three groups as diabetic wound (DC), diabetic wound saline (DS), and di
MHID-7269962PMID: 414217682025Reproductive toxicology (Elmsford, N.Y.)
Saroughi M, Kharazmi K, Asghari SZ, Aminian A, Nazari SE, Eshtad E, et al.
Hypothyroidism, characterized by insufficient thyroid hormone production, disrupts metabolic processes and impairs reproductive function. It is suggested that oxidative stress plays a key role in mediating the deleterious effects of hypothyroidism on testicular function and because of the antioxidative and anti-inflammatory effects of hydrogen-rich water (HRW), this study aimed to evaluate the eff
Clinical TrialAnimal StudyHighlighted
MHID-05612832025Sportivnaya meditsina: nauka i praktika (Sports medicine: research and practice)
Oleg S. Medvedev, Aleksey A. Uzhakov, Olga L. Konnova, Oxana V. Povarova
Purpose of the study: to investigate the effect of periodic hydrogen inhalations for one month on the main performance characteristics, lactate levels and other biochemical parameters determined in the blood of young wrestlers after physical activity.
Materials and methods. 10 healthy volunteer athletes took part in a prospective clinical study. The analysis of hydrogen and methane levels in exha
Observational Study
MHID-31585802025Sport Sciences for Health
Nikola Todorovic, Jovan Kuzmanovic, Dejan Javorac, Sergej M Ostojic
Purpose Exercise induces transient physiological disruptions, including immune suppression and gastrointestinal (GI) disturbance. Molecular hydrogen (H₂), an endogenously produced gas with antioxidant and anti-inflammatory properties, may play a protective role in this context. While the therapeutic potential of exogenous H₂ has been widely explored, little is known about endogenous hydrogen respo
Clinical TrialHighlighted
MHID-96660182025Journal of Physical Education and Sport
Jakub Krejčí, Michal Botek, Shigeo Ohta, Klara Botkova, Andrew McKune
Problem Statement: Effective inter-match recovery plays a crucial role in preserving performance and preventing injuries in well-trained soccer players. In this context, molecular hydrogen has attracted increasing attention in sports science due to its selective antioxidative, anti-inflammatory, and cell-signaling properties that may facilitate recovery. Among the various administration methods, h
Literature ReviewHighlighted
MHID-6700629PMID: 382422812025Medical Gas Research
Md. Habibur Rahman, Cheol-Su Kim, Kyu-Jae Lee
The antioxidant and anti-inflammatory properties of molecular hydrogen (H2) have been explored for their possible health advantages. H2 is the smallest and most basic molecule, and it may easily pass through cell membranes to reach cellular compartments. Research on the health significance of H2 is still in its early stages, and although some studies have yielded encouraging results, further resea
Animal StudyIn VitroHighlighted
MHID-9975059PMID: 394361892025Medical Gas Research
Wanqiu Chen, Yinyin Zhang, Gen Miao, Yajing Ying, Zifu Ren, Xuejun Sun, et al.
There is strong evidence connecting increased serum lipid levels to cardiovascular disorders, including atherosclerosis. Statins is prescribed as the primary medication to decrease lipid levels. Recent research has demonstrated that hydrogen possesses anti-inflammatory and antioxidant properties by modulating the expression of peroxisome proliferator-activated receptor gamma coactivator-1α, ultima
Observational StudyHighlighted
MHID-2151796PMID: 399341432025Scientific Reports
Masaaki Nakayama, Kimio Watanabe, Emiko Sato, Yugo Ito, Nozomi Kadota, Kasumi Konishi, et al.
Hemodialysis employing molecular hydrogen (H2)-enriched dialysis solution rendered by water electrolysis (E-HD), has been reported to alleviate dialysis-related fatigue, but its association with metabolic profiles remains unclear. Eighty-one patients undergoing standard HD were classified into 3 groups [Group A (n = 25, 30.9%): fatigue with activity reduction—subgroups A1: chronic persistent fatig
Literature Review
MHID-4621582PMID: 400680892025Medicine
Jiaxun Ying, Keran Zhang, Yangwen Huang, Xinyi Zhu, Yan Ruan, Haiyan Lin, et al.
Molecular hydrogen, as an effective anti-oxidative stress reagent, has been extensively studied in medicine with new developments continuing to be reported during the years. This review firstly discusses the mechanism of molecular hydrogen of alleviating oxidative stress. Considering the current antioxidant demand in clinical dental treatment, we summarize the progress and future potential of hydr
Opinion PieceOtherHighlighted
MHID-96353272025Frontiers in Neurology
Liu Dong-mei, Yao Jian-qiang, Ma Yan-e
Wu et al. (1) conducted a pioneering randomized controlled trial (RCT) to evaluate perioperative hydrogen inhalation in glioma patients, demonstrating a statistically significant reduction in postoperative brain edema and improved short-term neurological outcomes. While these findings highlight hydrogen’s potential as an adjuvant therapy, critical analysis from statistical and clinical perspectives
Animal StudyHighlighted
MHID-8093676PMID: 401048812025Veterinary Medicine and Science
Buket Boğa Kuru, Mustafa Makav, Mushap Kuru, Şükran Yediel Aras, Ebru Karadağ Sarı, Menekşe Bulut, et al.
Objectives: This study investigated the impact of drinking hydrogen-rich water (HRW) on growth performance, organ weights, thiol/disulphide homeostasis, oxidative status and some hormonal, histopathological and immunohistochemical changes in rats fed in a restricted housing environment.
Methods: The eight groups (each group [male/female] eight rats) comprised two control, two hydrogen, two stress
Clinical TrialObservational StudyHighlighted
MHID-1241888PMID: 400777852025Nutrients
Inna Misnikova, Yulia Kovaleva, Svetlana Shokur, Tyler W. LeBaron, Oxana Povarova, Oleg Medvedev
Background: The aim of this study was to investigate the relationship between postprandial glycemic levels based on flashmonitoring and the production of intestinal hydrogen (H2) and methane (CH4) gases based on the measurement of the amount of these gases in exhaled air. Materials and Methods: We studied 14 subjects with type 2 diabetes mellitus (T2DM) and 14 individuals without diabetes (control
