Molecular hydrogen gas and its therapeutic potential in recent disease progression

Abstract

The antioxidant and anti-inflammatory properties of molecular hydrogen (H2) have been explored for their possible health advantages. H2 is the smallest and most basic molecule, and it may easily pass through cell membranes to reach cellular compartments. Research on the health significance of H2 is still in its early stages, and although some studies have yielded encouraging results, further research is needed to understand its mechanisms and possible therapeutic applications fully. Numerous studies have shown that H2 may selectively scavenge damaging reactive oxygen species and modify inflammatory responses, suggesting that H2 may play a role in preventing oxidative stress-related diseases. H2 exerts its effects through a variety of mechanisms, including the lowering of proinflammatory cytokines, especially the activation of the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway.

Study details

Article type

Review

Disease / injury model

Neurodegenerative diseases (Alzheimer's, Parkinson's), Cardiovascular diseases, Respiratory diseases (ARDS, COPD)

Dose-dependent effect

No

Outcome

Positive

Findings

Molecular hydrogen (H2) shows promise as a therapeutic agent due to its antioxidant and anti-inflammatory properties, with potential benefits in neurodegenerative, cardiovascular, and respiratory diseases. Preclinical and some clinical studies indicate positive effects, but more rigorous clinical trials are needed to confirm safety and efficacy.