Literature ReviewHighlighted
MHID-6700629PMID: 382422812025Medical Gas Research
Md. Habibur Rahman, Cheol-Su Kim, Kyu-Jae Lee
The antioxidant and anti-inflammatory properties of molecular hydrogen (H2) have been explored for their possible health advantages. H2 is the smallest and most basic molecule, and it may easily pass through cell membranes to reach cellular compartments. Research on the health significance of H2 is still in its early stages, and although some studies have yielded encouraging results, further resea
Opinion PieceOtherHighlighted
MHID-96353272025Frontiers in Neurology
Liu Dong-mei, Yao Jian-qiang, Ma Yan-e
Wu et al. (1) conducted a pioneering randomized controlled trial (RCT) to evaluate perioperative hydrogen inhalation in glioma patients, demonstrating a statistically significant reduction in postoperative brain edema and improved short-term neurological outcomes. While these findings highlight hydrogen’s potential as an adjuvant therapy, critical analysis from statistical and clinical perspectives
Animal StudyHighlighted
MHID-2282117PMID: 408679002025Antioxidants
Ignacio Martínez-Martel, Sylmara Esther Negrini-Ferrari, Olga Pol
Cisplatin (CIS)-induced peripheral neuropathy and associated comorbidities have a detrimental effect on the lives of cancer patients. Currently, there are no effective therapies to alleviate these symptoms. Duloxetine (DULO) is a recommended treatment, but it is linked with important side effects, thus making it essential to explore novel approaches. We examined the impact of a prophylactic treatm
Animal StudyIn VitroHighlighted
MHID-7622818PMID: 407051912025Molecular Biology Reports
Yan Tian, Huilan Su, Yunxi Chen, Xiaomeng Geng, Yafang Zhang, Yu Wang, et al.
Background Nephrotoxicity is a common adverse effect of many chemotherapeutic agents and represents a major dose- limiting factor in cancer treatment. Therefore, developing effective renoprotective strategies is urgently needed. Molecular hydrogen (H2) has emerged as a therapeutic agent with potent antioxidant and anti-inflammatory properties, selectively scavenging hydroxyl radicals and alleviati
Clinical TrialHighlighted
MHID-9166764PMID: 408269302025Medical Gas Research
Yu Hong Gao, Jun Chen, Hua Zhong, Qiang Zhao
Sleep disorders are associated with various chronic diseases. While hydrogen has anti-inflammatory, antioxidant, and antifibrotic effects and has potential applications in disease management, its impact on sleep disorders remains unclear. This single-blind, randomized controlled clinical trial from September 2022 to July 2023 at the Second Medical Center of the PLA General Hospital and the Affilia
Animal StudyIn VitroHighlighted
MHID-1674678PMID: 407251672025International Journal of Molecular Sciences
Sofian Abdul-Nasir, Cat Tuong Chau, Tien Thuy Nguyen, Johny Bajgai, Md. Habibur Rahman, Kwon Hwang-Un, et al.
Alzheimer’s disease (AD) is a neurodegenerative condition in which amyloid-beta (Aβ) plaques trigger oxidative stress (OS) and neuroinflammation, causing memory loss. OS and neurodegeneration can also be caused by reactive astrocytes, thereby promoting AD via toxic metabolite accumulation in the astrocytic urea cycle. However, the effect of molecular hydrogen (H2) on this cycle remains unknown. Th
Literature ReviewHighlighted
MHID-0845802PMID: 399115282025Biochemistry and Biophysics Reports
Fatmanur Yıldız, Tyler W. LeBaron, Duried Alwazeer
Oxidative stress is responsible for the pathogenesis of many diseases, and antioxidants are commonly included in their treatment protocols. Over the past two decades, numerous biomedical reports have revealed the therapeutic benefits of molecular hydrogen (H2) in relieving oxidation-related diseases. H2 has been found to have selective antioxidant properties against the most dangerous oxidants (hy
Animal StudyHighlighted
MHID-15287492025Bratislava Medical Journal
Miktat Kaya, Mustafa Makav, Ebru Karadağ Sarı, Şükran Yediel Aras, Mushap Kuru, Abdussamed Vural, et al.
The aim of the study was to investigate the therapeutic efficacy of hydrogen-rich water in pentylenetetrazol-induced epilepsy. A total of 30 female rats, 6 animals in each group, were used in the study. All groups except the control group were ovariec- tomized. Hydrogen-rich water Group (HRW) and Epilepsy + HRW Group (E + HRW) were administered intraperitoneally for 14 days. On the 14th day of the
Literature ReviewHighlighted
MHID-44233202024Molecular Hydrogen in Health and Disease, Advances in Biochemistry in Health and Disease
Shin-ichi Hirano, Yusuke Ichikawa, Bunpei Sato, Yoshiyasu Takefuji, Xiao-Kang Li, Fumitake Satoh
Mitochondria originated from aerobic bacteria in endosymbiosis. Through this symbiosis, eukaryotes acquired an efficient energy-producing system, but at the cost of exposure to oxidative stress from reactive oxygen species (ROS). Molecular hydrogen (H2) was recently identified as an antioxidant that selectively reduces ROS, such as hydroxyl radicals and peroxynitrite, which are strong oxidants, and
Literature ReviewHighlighted
MHID-4821613PMID: 339191462024Pul’monologiya
Alexander G. Chuchalin
The aim of the review was to examine the main characteristics of hydrogen ion metabolism and its hemostatic function in the human body. For diagnostic purposes, molecular hydrogen (H2) is considered a biological marker. The results of the analysis of therapeutic programs for the clinical use of hydrogen are presented. The use of H2 as a drug in the treatment of more than 170 diseases is also discu
Animal Study
MHID-3239928PMID: 386383342024Frontiers in Pharmacology
Weiming Yan, Qiurui He, Pan Long, Tao Chen, Lei Zhang, Haiyan Wang
Objective Our research was performed in order to explore the effects of molecular hydrogen (H2), a novely-established antioxidant, on the retinal degeneration in rd1 mice, an animal model of inherited retinitis pigmentosa (RP).
Methods The rd1 mice were divided randomly into control and H2 intervention groups. Mice from other groups received H2 intervention in three modes, two modes of the hydrog
Clinical Trial
MHID-14786562024Current Developments in Nutrition
Sonja Baltic, Nikola Todorovic, Marijana Ranisavljev, Dragana Zanini, David Nedeljkovic, Darinka Korovljev, et al.
Objectives: Molecular hydrogen (H2) and pyrroloquinoline quinone (PQQ) have been suggested to activate metabolic pathways associated with cognition. No human studies have assessed the efficacy of this nutritional combination in the clinical context of mild cognitive impairment (MCI). The primary objective of this randomized placebo-controlled trial was to evaluate the effects of a six-week suppleme
Clinical TrialAnimal StudyHighlighted
MHID-3437190PMID: 391167822024Biomedicine & Pharmacotherapy
Bing Xie, Yong Wang, Yun Lu, Mengmeng Wang, Rongji Hui, Hailei Yu, et al.
The gut-brain axis mediates the interaction pathway between microbiota and opioid addiction. In recent years, many studies have shown that molecular hydrogen has therapeutic and preventive effects on various diseases. This study aimed to investigate whether molecular hydrogen could serve as pharmacological intervention agent to reduce risks of reinstatement of opioid seeking and explore the mechan
Observational Study
MHID-5046710PMID: 394774202024In Vivo
Jing-Yuan Chen, Jeng-Wei Lu, Shao-Wei Feng, Yi-Jung Ho, Shan-Wen Lui, Ting-Yu Hsieh, et al.
Background/Aim: Most nontraumatic subarachnoid hemorrhages (SAHs) are caused by ruptured saccular aneurysms, often resulting in a devastating clinical event characterized by high mortality and significant morbidity among survivors. Numerous studies have confirmed the neuroprotective effects of the molecular hydrogen due to its unique biological properties.
Case Report: We present the case of a 44
Animal StudyHighlighted
MHID-8765977PMID: 390619242024Antioxidants
Ignacio Martínez-Martel, Xue Bai, Rebecca Kordikowski, Christie R. A. Leite-Panissi, Olga Pol
Chemotherapy-provoked peripheral neuropathy and its associated affective disorders are important adverse effects in cancer patients, and its treatment is not completely resolved. A recent study reveals a positive interaction between molecular hydrogen (H2) and a heme oxygenase (HO-1) enzyme inducer, cobalt protoporphyrin IX (CoPP), in the inhibition of neuropathic pain provoked by nerve injury. Ne
Animal StudyHighlighted
MHID-5098246PMID: 382641422024Sleep Advances
Scott M. Vincent, Melika Madani, Dante Dikeman, Kyle Golden, Naomi Crocker, Cameron Jackson, et al.
Study Objectives: Sleep loss contributes to various health issues and impairs neurological function. Molecular hydrogen has recently gained popularity as a nontoxic ergogenic and health promoter. The effect of molecular hydrogen on sleep and sleep-related neural systems remains unexplored. This study investigates the impact of hydrogen-rich water (HRW) on sleep behavior and neuronal acti- vation i
Clinical TrialHighlighted
MHID-3345925PMID: 391330682024Critical Care Medicine
Tomoyoshi Tamura, MD, Hiromichi Narumiya, MD, Koichiro Homma, MD, Masaru Suzuki, MD
OBJECTIVE: The Efficacy of Inhaled Hydrogen on Neurologic Outcome Following Brain Ischemia During Post-Cardiac Arrest Care (HYBRID) II trial (jRCTs031180352) suggested that hydrogen inhalation may reduce post-cardiac arrest brain injury (PCABI). However, the combination of hypothermic target temperature management (TTM) and hydrogen inhalation on outcomes is unclear. The aim of this study was to i
Other
MHID-1413948PMID: 390733352024Medical Gas Research
Yusuke Ichikawa, Bunpei Sato, Shin-ichi Hirano, Yoshiyasu Takefuji, Fumitake Satoh
The Michael J. Fox Foundation has been funding research on Parkinson’s disease for 35 years, but has yet to find a cure. This is due to a problem with the philosophy behind the development of modern medical treatments. In this paper, we will introduce “smart medicine” with a substance that can solve all the problems of central nervous system drugs. The substance is the smallest diatomic molecule,
Animal StudyObservational StudyHighlighted
MHID-6966642PMID: 402326942024Medical Gas Research
Yusuke Ichikawa, Bunpei Sato, Shin-ichi Hirano, Yoshiyasu Takefuji, Fumitake Satoh
Amyotrophic lateral sclerosis (ALS) is a motor neuron disease, a neurodegenerative disorder characterized by sporadic and progressive degenerative loss of cell bodies of both the upper and lower motor neurons. Clinical manifestations of ALS are known to include lower motor neuron symptoms, upper motor neuron symptoms, bulboparesthesia symptoms, cognitive dysfunction, and negative signs. Dissociate
Observational Study
MHID-6877147PMID: 365168982023Brain Research Bulletin
Yong Wang, Mengmeng Wang, Bing Xie, Di Wen, Wenbo Li, Meiqi Zhou, et al.
Methamphetamine (METH) is a potent and highly addictive psychostimulant and one of the most widely used illicit drugs, the abuse of which has become a severe public health problem worldwide. A growing amount of evidence has indicated potential connections between gut microbiota and mental disorders induced by METH and associations with neural and metabolic pathways. The present study aimed to expl
