Molecular hydrogen Mechanism against oxidative stress and application in periodontitis: A review

Abstract

Molecular hydrogen, as an effective anti-oxidative stress reagent, has been extensively studied in medicine with new developments continuing to be reported during the years. This review firstly discusses the mechanism of molecular hydrogen of alleviating oxidative stress. Considering the current antioxidant demand in clinical dental treatment, we summarize the progress and future potential of hydrogen’s application in periodontitis. Finally, taking its treatment of periodontitis as an example, we develop an Essence-Necessity-Feasibility-Practice (ENFP) benefit evaluation model for whether to introduce new reagents in medical treatment and propose our conclusions on the application of molecular hydrogen before, during, and after periodontal surgeries.

Study details

Article type

Review

Disease / injury model

The review focuses on periodontitis and oral health

Dose-dependent effect

No

Outcome

Positive

Findings

Based on its positive properties in palate healing, hydrogen may be applied to fields like oral mucosal diseases, oral and maxillofacial surgery, etc. The rational use of hydrogen, and the popularization of medical treatment with it, will not only improve the social medical condition, but also contribute to the sustainable development of the whole society