Systematic ReviewHighlighted
MHID-43477742026World Journal of Orthopedics
Naveen Jeyaraman, Madhan Jeyaraman, Swaminathan Ramasubramanian, Shrideavi Murugan, Arulkumar Nallakumarasamy, Sathish Muthu
Molecular hydrogen (H2) demonstrates selective antioxidant and anti-inflam-
matory properties with therapeutic potential across musculoskeletal conditions
including osteoarthritis, rheumatoid arthritis, exercise-induced muscle damage,
chronic pain syndromes, tendinopathies, and muscle atrophy. This review
critically evaluates preclinical and clinical evidence for H2 therapy and identifies
research
Clinical TrialAnimal StudyHighlighted
MHID-05612832025Sportivnaya meditsina: nauka i praktika (Sports medicine: research and practice)
Oleg S. Medvedev, Aleksey A. Uzhakov, Olga L. Konnova, Oxana V. Povarova
Purpose of the study: to investigate the effect of periodic hydrogen inhalations for one month on the main performance characteristics, lactate levels and other biochemical parameters determined in the blood of young wrestlers after physical activity.
Materials and methods. 10 healthy volunteer athletes took part in a prospective clinical study. The analysis of hydrogen and methane levels in exha
Literature Review
MHID-4621582PMID: 400680892025Medicine
Jiaxun Ying, Keran Zhang, Yangwen Huang, Xinyi Zhu, Yan Ruan, Haiyan Lin, et al.
Molecular hydrogen, as an effective anti-oxidative stress reagent, has been extensively studied in medicine with new developments continuing to be reported during the years. This review firstly discusses the mechanism of molecular hydrogen of alleviating oxidative stress. Considering the current antioxidant demand in clinical dental treatment, we summarize the progress and future potential of hydr
Literature Review
MHID-1191317PMID: 406196052025Advanced Science
Gangfeng Li, Hannan Cui, Ruixiao Fan, Guming Liu, Zishuo Hou, Yibo Zhang, et al.
The delivery of molecular hydrogen (H2) is increasingly recognized for its potential in precision immunomodulation, primarily through multiple pathways such as antioxidant action, modulation of inflammatory factors, and inhibition of apoptosis. These effects contribute to a balanced and functional immune system, highlighting the therapeutic promise of H2 in various inflammatory conditions. However, t
Animal StudyHighlighted
MHID-4439338PMID: 401810802025Scientific Reports
Victor Pascal-Moussellard, Jean-Pierre Alcaraz, Stéphane Tanguy, Cordélia Salomez-Ihl, Philippe Cinquin, François Boucher, et al.
Inulin consumption and dihydrogen (H2) administration both exert antitumor effects on preclinical models as well as in clinical trials. As H2 is one of the major byproducts of inulin fermentation by bacterial species of the gut microbiota (GM), we hypothesized that H2 could mediate the antitumor effects of inulin. To provide evidence in favor of this hypothesis, we first determined the pattern of
Clinical TrialHighlighted
MHID-8924760PMID: 408680532025Biomedicines
Takafumi Maruyama, Dai Ishikawa, Rina Kurokawa, Hiroaki Masuoka, Kei Nomura, Mayuko Haraikawa, et al.
Background/Objective: Dysbiosis is implicated in the pathogenesis of ulcerative colitis. Hydrogen has been reported to promote intestinal microbiota diversity and suppress ulcerative colitis progression in mice models. In this study, we investigated changes in the intestinal microbiota, therapeutic effects, and safety of hydrogen inhalation in patients with ulcerative colitis.
Methods: In this ra
Clinical TrialHighlighted
MHID-5491717PMID: 412043202025Trials
Victoria Habet, Tysen DeWaard, Krislyn M. Boggs, Alix Fetch, Bao Nguyen Puente, Lynn A. Sleeper, et al.
Background: Extracorporeal cardiopulmonary resuscitation (ECPR) improves survival for patients experiencing refractory cardiac arrest but is often associated with severe ischemia-reperfusion injury (IRI). Hydrogen gas (H2) has demonstrated promising preclinical efficacy in reducing IRI. The Hydrogen-FAST trial investigates the feasibility and safety of inhaled hydrogen gas as an adjunctive therapy
Animal StudyHighlighted
MHID-6800574PMID: 414626182025Antioxidants
Anna Vyacheslavovna Deryugina, Darya Andreevna Danilova, Anastasia Vladimirovna Polozova
Oxidative stress is a key factor in the development of chronic heart failure (CHF). Molecular hydrogen (H2) exhibits antioxidant properties, yet the mechanisms by which it alleviates hemodynamic disturbances and ischemic myocardial injury in CHF are not fully under- stood. This study examined the effects of a single (40-min) and multiple (40-min daily for 5 days) inhalations of H2 in a rat model o
Animal StudyHighlighted
MHID-5014710PMID: 407174652025British Journal of Pharmacology
Shuqi Meng, Jianfeng Liu, Yanhua Luo, Yan Fan, Zhiwei Wang, Yu Song, et al.
Background and Purpose: Sepsis-induced cardiomyopathy (SIC) is the primary cause of mortality among people with sepsis. Hydrogen (H2) has a cardioprotective effect in SIC; however, its specific mechanism remains unclear. We thus explored whether 2% H2 treatment mitigates SIC through inhibiting Golgi stress and investigated the specific molecular pathways underlying this protective effect.
Experime
Literature ReviewHighlighted
MHID-2922681PMID: 413737252025International Journal of Molecular Sciences
Daria Kornieieva, Barbora Kalocayova, Jan Slezak, Branislav Kura
Heart failure (HF) is increasing in prevalence in many countries around the world. HF is a complex clinical syndrome characterized by the heart’s inability to pump blood effectively, resulting in significant morbidity and mortality. After an initial cardiac event (e.g., myocardial infarction, valve dysfunction, hypertension, etc.), adaptive mechanisms are activated to preserve cardiac function. Su
Animal StudyIn VitroHighlighted
MHID-7622818PMID: 407051912025Molecular Biology Reports
Yan Tian, Huilan Su, Yunxi Chen, Xiaomeng Geng, Yafang Zhang, Yu Wang, et al.
Background Nephrotoxicity is a common adverse effect of many chemotherapeutic agents and represents a major dose- limiting factor in cancer treatment. Therefore, developing effective renoprotective strategies is urgently needed. Molecular hydrogen (H2) has emerged as a therapeutic agent with potent antioxidant and anti-inflammatory properties, selectively scavenging hydroxyl radicals and alleviati
Literature ReviewHighlighted
MHID-45792272025International Journal of Molecular Sciences
Dominika Zajac, Monika Jampolska, Piotr Wojciechowski
Molecular hydrogen is gaining increasing attention as an antioxidant, anti-
inflammatory, and antiapoptotic agent. Once considered an inert gas, it reveals current
therapeutic potential among others in inflammatory diseases, cancer, and sports medicine,
among others. The present review aims to provide a consistent summary of the findings
of the last twenty years on the use of molecular hydrogen in
Hypothesis
MHID-2190797PMID: 409385202025Intensive Care Medicine Experimental
Lakhmir S. Chawla
Molecular hydrogen gas (HG), administered through inhalation or as hydrogen-rich fluids (HRF), has demonstrated antioxidant, anti-inflammatory, antiapoptotic, cytoprotective, and beneficial mitochondrial effects in critical illness. Preclinical studies and human clinical studies consistently endorse hydrogen gas as safe, with mechanisms of action linked to vital molecular pathways, such as reducti
Clinical TrialHighlighted
MHID-9166764PMID: 408269302025Medical Gas Research
Yu Hong Gao, Jun Chen, Hua Zhong, Qiang Zhao
Sleep disorders are associated with various chronic diseases. While hydrogen has anti-inflammatory, antioxidant, and antifibrotic effects and has potential applications in disease management, its impact on sleep disorders remains unclear. This single-blind, randomized controlled clinical trial from September 2022 to July 2023 at the Second Medical Center of the PLA General Hospital and the Affilia
Clinical TrialHighlighted
MHID-1036598PMID: 399231332025Medical Gas Research
Pavel Grepl, Michal Botek, Jakub Krejčí, Andrew McKune
Initially, molecular hydrogen was considered a physiologically inert and non-functional gas. However, experimental and clinical studies have shown that molecular hydrogen has anti-inflammatory, anti-apoptotic, and strong selective antioxidant effects. This study aimed to evaluate the effects of 60 minutes of molecular hydrogen inhalation on respiratory gas analysis parameters using a randomized, d
Animal StudyIn VitroHighlighted
MHID-1674678PMID: 407251672025International Journal of Molecular Sciences
Sofian Abdul-Nasir, Cat Tuong Chau, Tien Thuy Nguyen, Johny Bajgai, Md. Habibur Rahman, Kwon Hwang-Un, et al.
Alzheimer’s disease (AD) is a neurodegenerative condition in which amyloid-beta (Aβ) plaques trigger oxidative stress (OS) and neuroinflammation, causing memory loss. OS and neurodegeneration can also be caused by reactive astrocytes, thereby promoting AD via toxic metabolite accumulation in the astrocytic urea cycle. However, the effect of molecular hydrogen (H2) on this cycle remains unknown. Th
Literature Review
MHID-3242181PMID: 405693542025Molecular Biology Reports
Yong Ye, Zi-hang Yu, Liang Nie, Bin Lu, Guo Mu
Pyroptosis, a highly inflammatory programmed cell death pathway, drives pathogenesis in numerous diseases through gasdermin-mediated membrane pore formation and massive cytokine release. While conventional anti-inflammatory therapies show limited efficacy, hydrogen emerges as a novel therapeutic agent with unique pyroptosis-regulatory capabilities. This review establishes a comprehensive mechanist
Literature ReviewHighlighted
MHID-0845802PMID: 399115282025Biochemistry and Biophysics Reports
Fatmanur Yıldız, Tyler W. LeBaron, Duried Alwazeer
Oxidative stress is responsible for the pathogenesis of many diseases, and antioxidants are commonly included in their treatment protocols. Over the past two decades, numerous biomedical reports have revealed the therapeutic benefits of molecular hydrogen (H2) in relieving oxidation-related diseases. H2 has been found to have selective antioxidant properties against the most dangerous oxidants (hy
Literature ReviewHighlighted
MHID-44233202024Molecular Hydrogen in Health and Disease, Advances in Biochemistry in Health and Disease
Shin-ichi Hirano, Yusuke Ichikawa, Bunpei Sato, Yoshiyasu Takefuji, Xiao-Kang Li, Fumitake Satoh
Mitochondria originated from aerobic bacteria in endosymbiosis. Through this symbiosis, eukaryotes acquired an efficient energy-producing system, but at the cost of exposure to oxidative stress from reactive oxygen species (ROS). Molecular hydrogen (H2) was recently identified as an antioxidant that selectively reduces ROS, such as hydroxyl radicals and peroxynitrite, which are strong oxidants, and
Literature ReviewHighlighted
MHID-4821613PMID: 339191462024Pul’monologiya
Alexander G. Chuchalin
The aim of the review was to examine the main characteristics of hydrogen ion metabolism and its hemostatic function in the human body. For diagnostic purposes, molecular hydrogen (H2) is considered a biological marker. The results of the analysis of therapeutic programs for the clinical use of hydrogen are presented. The use of H2 as a drug in the treatment of more than 170 diseases is also discu
