Systematic ReviewHighlighted
MHID-43477742026World Journal of Orthopedics
Naveen Jeyaraman, Madhan Jeyaraman, Swaminathan Ramasubramanian, Shrideavi Murugan, Arulkumar Nallakumarasamy, Sathish Muthu
Molecular hydrogen (H2) demonstrates selective antioxidant and anti-inflam-
matory properties with therapeutic potential across musculoskeletal conditions
including osteoarthritis, rheumatoid arthritis, exercise-induced muscle damage,
chronic pain syndromes, tendinopathies, and muscle atrophy. This review
critically evaluates preclinical and clinical evidence for H2 therapy and identifies
research
Observational StudyHighlighted
MHID-67657942026medRxiv
Yuusuke Harada, Michiko Miyakawa
Background: Falls among older adults are a leading cause of fractures, loss of independence, and need for long-term care. Community salons in Japan promote social participation and health activities among older adults. Hydrogen-rich water is widely used as a health product, but evidence in community settings remains limited.
Methods: We conducted a prospective observational study among 48 communit
Observational Study
MHID-31585802025Sport Sciences for Health
Nikola Todorovic, Jovan Kuzmanovic, Dejan Javorac, Sergej M Ostojic
Purpose Exercise induces transient physiological disruptions, including immune suppression and gastrointestinal (GI) disturbance. Molecular hydrogen (H₂), an endogenously produced gas with antioxidant and anti-inflammatory properties, may play a protective role in this context. While the therapeutic potential of exogenous H₂ has been widely explored, little is known about endogenous hydrogen respo
Clinical TrialHighlighted
MHID-96660182025Journal of Physical Education and Sport
Jakub Krejčí, Michal Botek, Shigeo Ohta, Klara Botkova, Andrew McKune
Problem Statement: Effective inter-match recovery plays a crucial role in preserving performance and preventing injuries in well-trained soccer players. In this context, molecular hydrogen has attracted increasing attention in sports science due to its selective antioxidative, anti-inflammatory, and cell-signaling properties that may facilitate recovery. Among the various administration methods, h
Observational StudyHighlighted
MHID-2151796PMID: 399341432025Scientific Reports
Masaaki Nakayama, Kimio Watanabe, Emiko Sato, Yugo Ito, Nozomi Kadota, Kasumi Konishi, et al.
Hemodialysis employing molecular hydrogen (H2)-enriched dialysis solution rendered by water electrolysis (E-HD), has been reported to alleviate dialysis-related fatigue, but its association with metabolic profiles remains unclear. Eighty-one patients undergoing standard HD were classified into 3 groups [Group A (n = 25, 30.9%): fatigue with activity reduction—subgroups A1: chronic persistent fatig
Literature Review
MHID-4621582PMID: 400680892025Medicine
Jiaxun Ying, Keran Zhang, Yangwen Huang, Xinyi Zhu, Yan Ruan, Haiyan Lin, et al.
Molecular hydrogen, as an effective anti-oxidative stress reagent, has been extensively studied in medicine with new developments continuing to be reported during the years. This review firstly discusses the mechanism of molecular hydrogen of alleviating oxidative stress. Considering the current antioxidant demand in clinical dental treatment, we summarize the progress and future potential of hydr
Opinion PieceOtherHighlighted
MHID-96353272025Frontiers in Neurology
Liu Dong-mei, Yao Jian-qiang, Ma Yan-e
Wu et al. (1) conducted a pioneering randomized controlled trial (RCT) to evaluate perioperative hydrogen inhalation in glioma patients, demonstrating a statistically significant reduction in postoperative brain edema and improved short-term neurological outcomes. While these findings highlight hydrogen’s potential as an adjuvant therapy, critical analysis from statistical and clinical perspectives
Clinical TrialObservational StudyHighlighted
MHID-1241888PMID: 400777852025Nutrients
Inna Misnikova, Yulia Kovaleva, Svetlana Shokur, Tyler W. LeBaron, Oxana Povarova, Oleg Medvedev
Background: The aim of this study was to investigate the relationship between postprandial glycemic levels based on flashmonitoring and the production of intestinal hydrogen (H2) and methane (CH4) gases based on the measurement of the amount of these gases in exhaled air. Materials and Methods: We studied 14 subjects with type 2 diabetes mellitus (T2DM) and 14 individuals without diabetes (control
HypothesisOpinion PieceHighlighted
MHID-6155704PMID: 402510252025Medical Gas Research
Nikola Todorovic, Jovan Kuzmanovic, Dejan Javorac, Sergej M Ostojic
The increasing prevalence of obesity and non-communicable diseases has become a major global health concern, contributing to significant morbidity and mortality rates. These conditions not only burden healthcare systems but also affect the individual’s quality of life worldwide. As these challenges continue to grow, there is a pressing need to explore treatment options that are effective, affordab
MHID-88889642025International Journal of Radiation Oncology Biology Physics
K.M. Mani, C.M. Maruschak, C. Vacchi-Suzzi, H. Munoz, L. Joya, A.N. Slade, et al.
Purpose/Objective(s): Radiation is a mainstay of therapy for head/neck cancer. However, patients invariably develop mucositis along the targeted subsite, which persists during and after treatment, leading to weight loss, hospital admissions and potentially treatment interruptions. Hydrogen-rich water (HRW) is an available supplement that is thought to scavenge free radicals and confer anti-inflamma
Clinical TrialHighlighted
MHID-8924760PMID: 408680532025Biomedicines
Takafumi Maruyama, Dai Ishikawa, Rina Kurokawa, Hiroaki Masuoka, Kei Nomura, Mayuko Haraikawa, et al.
Background/Objective: Dysbiosis is implicated in the pathogenesis of ulcerative colitis. Hydrogen has been reported to promote intestinal microbiota diversity and suppress ulcerative colitis progression in mice models. In this study, we investigated changes in the intestinal microbiota, therapeutic effects, and safety of hydrogen inhalation in patients with ulcerative colitis.
Methods: In this ra
Literature ReviewHighlighted
MHID-2922681PMID: 413737252025International Journal of Molecular Sciences
Daria Kornieieva, Barbora Kalocayova, Jan Slezak, Branislav Kura
Heart failure (HF) is increasing in prevalence in many countries around the world. HF is a complex clinical syndrome characterized by the heart’s inability to pump blood effectively, resulting in significant morbidity and mortality. After an initial cardiac event (e.g., myocardial infarction, valve dysfunction, hypertension, etc.), adaptive mechanisms are activated to preserve cardiac function. Su
Literature ReviewHighlighted
MHID-45792272025International Journal of Molecular Sciences
Dominika Zajac, Monika Jampolska, Piotr Wojciechowski
Molecular hydrogen is gaining increasing attention as an antioxidant, anti-
inflammatory, and antiapoptotic agent. Once considered an inert gas, it reveals current
therapeutic potential among others in inflammatory diseases, cancer, and sports medicine,
among others. The present review aims to provide a consistent summary of the findings
of the last twenty years on the use of molecular hydrogen in
Hypothesis
MHID-2190797PMID: 409385202025Intensive Care Medicine Experimental
Lakhmir S. Chawla
Molecular hydrogen gas (HG), administered through inhalation or as hydrogen-rich fluids (HRF), has demonstrated antioxidant, anti-inflammatory, antiapoptotic, cytoprotective, and beneficial mitochondrial effects in critical illness. Preclinical studies and human clinical studies consistently endorse hydrogen gas as safe, with mechanisms of action linked to vital molecular pathways, such as reducti
Clinical TrialHighlighted
MHID-9166764PMID: 408269302025Medical Gas Research
Yu Hong Gao, Jun Chen, Hua Zhong, Qiang Zhao
Sleep disorders are associated with various chronic diseases. While hydrogen has anti-inflammatory, antioxidant, and antifibrotic effects and has potential applications in disease management, its impact on sleep disorders remains unclear. This single-blind, randomized controlled clinical trial from September 2022 to July 2023 at the Second Medical Center of the PLA General Hospital and the Affilia
Clinical TrialHighlighted
MHID-1036598PMID: 399231332025Medical Gas Research
Pavel Grepl, Michal Botek, Jakub Krejčí, Andrew McKune
Initially, molecular hydrogen was considered a physiologically inert and non-functional gas. However, experimental and clinical studies have shown that molecular hydrogen has anti-inflammatory, anti-apoptotic, and strong selective antioxidant effects. This study aimed to evaluate the effects of 60 minutes of molecular hydrogen inhalation on respiratory gas analysis parameters using a randomized, d
Clinical Trial
MHID-98854012024Science & Sports
S.H. Ryu, J.H. Oh, K.W. Noh, S. Park
Summary
Objective: This study aimed to contribute towards improving athletic performance by comparing the effects of highly concentrated hydrogen intake before and during exercise on soccer players’ metabolic and athletic performance.
Materials and methods: This study followed a single-blind crossover design involving 10 male college soccer players. Before this experiment, the Vmax measurement a
Systematic Review
MHID-7472923PMID: 382560452024International Journal of Molecular Sciences
Gagandeep Dhillon, Venkata Buddhavarapu, Harpreet Grewal, Pranjal Sharma, Ram Kishun Verma, Ripudaman Munjal, et al.
Hydrogen-rich water (HRW) has emerged as a novel approach in the field of health and wellness. It is believed to have therapeutic antioxidant properties that can neutralize harmful free radicals in the human body. It has also been shown to be beneficial in mitigating oxidative stress-induced damage through its anti-inflammatory and anti-apoptotic pathways. We aim to conduct a systematic review to
Clinical Trial
MHID-8109346PMID: 390647852024Nutrients
Gengxin Dong, Haiyan Liu, Yunji Chen, Dapeng Bao, Wentao Xu, Junhong Zhou
Background: The diversity of blood biomarkers used to assess the metabolic mechanisms of hydrogen limits a comprehensive understanding of its effects on improving exercise performance. This study evaluated the impact of hydrogen-rich gas (HRG) on metabolites following sprint-interval exercise using metabolomics approaches, aiming to elucidate its underlying mechanisms of action.
Methods: Ten heal
Clinical Trial
MHID-0740382PMID: 386986242024International Journal of Sports Medicine
Gengxin Dong, Jianxin Wu, Yinglu Hong, Qian Li, Meng Liu, Guole Jiang, et al.
Hydrogen, as an antioxidant, may have the potential to mitigate fatigue and improve selected oxidative stress markers induced by strenuous exercise. This study focused on a previously unexplored approach involving pre-exercise inhalation of hydrogen-rich gas (HRG). Twenty-four healthy adult men first completed pre-laboratories to determine maximum cycling power (Wmax) and maximum cycling time (Tma
