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Literature Review

Molecular hydrogen Mechanism against oxidative stress and application in periodontitis: A review

MHID-4621582PMID: 400680892025Medicine

Jiaxun Ying, Keran Zhang, Yangwen Huang, Xinyi Zhu, Yan Ruan, Haiyan Lin, et al.

Molecular hydrogen, as an effective anti-oxidative stress reagent, has been extensively studied in medicine with new developments continuing to be reported during the years. This review firstly discusses the mechanism of molecular hydrogen of alleviating oxidative stress. Considering the current antioxidant demand in clinical dental treatment, we summarize the progress and future potential of hydr

Clinical TrialAnimal StudyHighlighted

Randomized, crossover clinical efficacy trial in humans and mice on tear secretion promotion and lacrimal gland protection by molecular hydrogen

MHID-8498103PMID: 337420602021Scientific Reports

Miyuki Kubota, Motoko Kawashima, Sachiko Inoue, Toshihiro Imada, Shigeru Nakamura, Shunsuke Kubota, et al.

The incidence of dry eye disease is increasing worldwide because of the aging population and increasing use of information technology. Dry eye disease manifests as tear-layer instability and inflammation caused by osmotic hypersensitization in tear fluids; however, to our knowledge, no agent that treats both pathologies simultaneously is available. Molecular hydrogen (H2) is known to be effective