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Literature Review

Molecular hydrogen Mechanism against oxidative stress and application in periodontitis: A review

MHID-4621582PMID: 400680892025Medicine

Jiaxun Ying, Keran Zhang, Yangwen Huang, Xinyi Zhu, Yan Ruan, Haiyan Lin, et al.

Molecular hydrogen, as an effective anti-oxidative stress reagent, has been extensively studied in medicine with new developments continuing to be reported during the years. This review firstly discusses the mechanism of molecular hydrogen of alleviating oxidative stress. Considering the current antioxidant demand in clinical dental treatment, we summarize the progress and future potential of hydr

Chemical/Physicochemical Study

ONOOH does not react with H2: Potential beneficial effects of H2 as an antioxidant by selective reaction with hydroxyl radicals and peroxynitrite

MHID-6682168PMID: 250864382014Free Radical Biology and Medicine

Jelle Penders, Reinhard Kissner, Willem H. Koppenol

H2 has been suggested to act as an antioxidant when administered just before the reperfusion phase of induced oxidative stress. These effects have been reported, for example, for the heart, brain, and liver. It is hypothesized that this beneficial effect may be due to selective scavenging of HO⋅ and ONOOH by H2. The reaction of H2 with HO⋅ has been studied by pulse radiolysis in the past and is too