Animal StudyHighlighted
MHID-6979663PMID: 401889722025Toxicology and Applied Pharmacology
Mohammad Hossein Rigi, Seyyedeh Zahra Asghari, Elaheh Eshtad, Seyedeh Elnaz Nazari, Akram Aminian, Khatereh Kharazmi, et al.
Obesity can impair spermatogenesis by various mechanisms such as decreased sperm concentration and increased oxidative DNA damage. Hydrogen-rich water (HRW) possesses therapeutic antioxidant properties that may help offer protection to sperm. This study aimed to investigate the therapeutic potential of HRW on spermatogenesis dysfunction in rats with high-fat diet (HFD)-induced obesity. In this exp
Literature Review
MHID-1191317PMID: 406196052025Advanced Science
Gangfeng Li, Hannan Cui, Ruixiao Fan, Guming Liu, Zishuo Hou, Yibo Zhang, et al.
The delivery of molecular hydrogen (H2) is increasingly recognized for its potential in precision immunomodulation, primarily through multiple pathways such as antioxidant action, modulation of inflammatory factors, and inhibition of apoptosis. These effects contribute to a balanced and functional immune system, highlighting the therapeutic promise of H2 in various inflammatory conditions. However, t
MHID-3995858PMID: 400369132025Parkinsonism & related disorders
Baltic S, Todorović N, Popovic S, Galic V, Semnic M, Ostojic SM.
Over 10 million individuals worldwide are living with Parkinson's disease (PD), a serious neurodegenerative condition with an unclear etiology. It is widely accepted that PD arises from a complex interplay of genetic and environmental factors, leading to the gradual degeneration of both motor and non-motor systems. Various microbial metabolites and products have been implicated in PD pathology, al
MHID-57032162025Research in sports medicine (Print)
Kuzmanovic J, Todorović N, Ranisavljev M, Javorac D, Korovljev D, Tarnava A, et al.
The primary objective of this pilot study was to assess the impact of consuming hydrogen-rich water (HRW) for a duration of six weeks on exercise-related biomarkers in previously untrained men and women aged over 50 years, subsequent to a resistance training program. Twenty-seven apparently healthy middle-aged adults (age 57.6 ± 6.7 years; 18 females) voluntarily provided written consent to partic
HypothesisOpinion PieceHighlighted
MHID-6155704PMID: 402510252025Medical Gas Research
Nikola Todorovic, Jovan Kuzmanovic, Dejan Javorac, Sergej M Ostojic
The increasing prevalence of obesity and non-communicable diseases has become a major global health concern, contributing to significant morbidity and mortality rates. These conditions not only burden healthcare systems but also affect the individual’s quality of life worldwide. As these challenges continue to grow, there is a pressing need to explore treatment options that are effective, affordab
MHID-88889642025International Journal of Radiation Oncology Biology Physics
K.M. Mani, C.M. Maruschak, C. Vacchi-Suzzi, H. Munoz, L. Joya, A.N. Slade, et al.
Purpose/Objective(s): Radiation is a mainstay of therapy for head/neck cancer. However, patients invariably develop mucositis along the targeted subsite, which persists during and after treatment, leading to weight loss, hospital admissions and potentially treatment interruptions. Hydrogen-rich water (HRW) is an available supplement that is thought to scavenge free radicals and confer anti-inflamma
Animal StudyHighlighted
MHID-4439338PMID: 401810802025Scientific Reports
Victor Pascal-Moussellard, Jean-Pierre Alcaraz, Stéphane Tanguy, Cordélia Salomez-Ihl, Philippe Cinquin, François Boucher, et al.
Inulin consumption and dihydrogen (H2) administration both exert antitumor effects on preclinical models as well as in clinical trials. As H2 is one of the major byproducts of inulin fermentation by bacterial species of the gut microbiota (GM), we hypothesized that H2 could mediate the antitumor effects of inulin. To provide evidence in favor of this hypothesis, we first determined the pattern of
Clinical TrialHighlighted
MHID-8924760PMID: 408680532025Biomedicines
Takafumi Maruyama, Dai Ishikawa, Rina Kurokawa, Hiroaki Masuoka, Kei Nomura, Mayuko Haraikawa, et al.
Background/Objective: Dysbiosis is implicated in the pathogenesis of ulcerative colitis. Hydrogen has been reported to promote intestinal microbiota diversity and suppress ulcerative colitis progression in mice models. In this study, we investigated changes in the intestinal microbiota, therapeutic effects, and safety of hydrogen inhalation in patients with ulcerative colitis.
Methods: In this ra
Clinical TrialHighlighted
MHID-5491717PMID: 412043202025Trials
Victoria Habet, Tysen DeWaard, Krislyn M. Boggs, Alix Fetch, Bao Nguyen Puente, Lynn A. Sleeper, et al.
Background: Extracorporeal cardiopulmonary resuscitation (ECPR) improves survival for patients experiencing refractory cardiac arrest but is often associated with severe ischemia-reperfusion injury (IRI). Hydrogen gas (H2) has demonstrated promising preclinical efficacy in reducing IRI. The Hydrogen-FAST trial investigates the feasibility and safety of inhaled hydrogen gas as an adjunctive therapy
MHID-1944895PMID: 405180212025Ageing research reviews
Brandi G, Delbaldo C, Deserti M, Relli V, Rimedio S, Palloni A, et al.
Aging represents the main risk factor for the development of several diseases, including cardiovascular and metabolic conditions, neurodegenerative disorders and cancer. As the number of elderly people is increasing worldwide, different strategies to counteract age-related diseases have been investigated. Recently, the use of molecular hydrogen (H2) as a preventive and therapeutic approach has bee
Animal StudyHighlighted
MHID-6800574PMID: 414626182025Antioxidants
Anna Vyacheslavovna Deryugina, Darya Andreevna Danilova, Anastasia Vladimirovna Polozova
Oxidative stress is a key factor in the development of chronic heart failure (CHF). Molecular hydrogen (H2) exhibits antioxidant properties, yet the mechanisms by which it alleviates hemodynamic disturbances and ischemic myocardial injury in CHF are not fully under- stood. This study examined the effects of a single (40-min) and multiple (40-min daily for 5 days) inhalations of H2 in a rat model o
Animal StudyHighlighted
MHID-5014710PMID: 407174652025British Journal of Pharmacology
Shuqi Meng, Jianfeng Liu, Yanhua Luo, Yan Fan, Zhiwei Wang, Yu Song, et al.
Background and Purpose: Sepsis-induced cardiomyopathy (SIC) is the primary cause of mortality among people with sepsis. Hydrogen (H2) has a cardioprotective effect in SIC; however, its specific mechanism remains unclear. We thus explored whether 2% H2 treatment mitigates SIC through inhibiting Golgi stress and investigated the specific molecular pathways underlying this protective effect.
Experime
Literature ReviewHighlighted
MHID-2922681PMID: 413737252025International Journal of Molecular Sciences
Daria Kornieieva, Barbora Kalocayova, Jan Slezak, Branislav Kura
Heart failure (HF) is increasing in prevalence in many countries around the world. HF is a complex clinical syndrome characterized by the heart’s inability to pump blood effectively, resulting in significant morbidity and mortality. After an initial cardiac event (e.g., myocardial infarction, valve dysfunction, hypertension, etc.), adaptive mechanisms are activated to preserve cardiac function. Su
Animal StudyHighlighted
MHID-2282117PMID: 408679002025Antioxidants
Ignacio Martínez-Martel, Sylmara Esther Negrini-Ferrari, Olga Pol
Cisplatin (CIS)-induced peripheral neuropathy and associated comorbidities have a detrimental effect on the lives of cancer patients. Currently, there are no effective therapies to alleviate these symptoms. Duloxetine (DULO) is a recommended treatment, but it is linked with important side effects, thus making it essential to explore novel approaches. We examined the impact of a prophylactic treatm
MHID-2496721PMID: 397529982025Redox Biology
Linlin Zhang, Fangshi Zhao, Yize Li, Zhenhua Song, Lingyue Hu, Yuanjie Li, et al.
Chronic itch which is primarily associated with dermatologic, systemic, or metabolic disorders is often refractory to most current antipruritic medications, thus highlighting the need for improved therapies. Oxidative damage is a novel determinant of spinal pruriceptive sensitization and synaptic plasticity. The resolution of oxidative insult by molecular hydrogen has been manifested. Herein, we s
Animal StudyIn VitroHighlighted
MHID-7622818PMID: 407051912025Molecular Biology Reports
Yan Tian, Huilan Su, Yunxi Chen, Xiaomeng Geng, Yafang Zhang, Yu Wang, et al.
Background Nephrotoxicity is a common adverse effect of many chemotherapeutic agents and represents a major dose- limiting factor in cancer treatment. Therefore, developing effective renoprotective strategies is urgently needed. Molecular hydrogen (H2) has emerged as a therapeutic agent with potent antioxidant and anti-inflammatory properties, selectively scavenging hydroxyl radicals and alleviati
Literature Review
MHID-1025411PMID: 411942432025European Journal of Medical Research
Qian Zhu, Xianzhi Li, Shiyang Li, Shunjin Liu, Yunyun Tian, Xiangyi Xing, et al.
Oxidative stress and inflammation play a key role in the occurrence and progression of liver diseases, inducing hepatocyte apoptosis, fibrosis, and even cancer. However, there is a lack of effective therapeutic interventions to slow liver inflammation and the progression of metabolic liver diseases. The unique biological properties of molecular hydrogen’s selective scavenging of pathological free
Literature ReviewHighlighted
MHID-45792272025International Journal of Molecular Sciences
Dominika Zajac, Monika Jampolska, Piotr Wojciechowski
Molecular hydrogen is gaining increasing attention as an antioxidant, anti-
inflammatory, and antiapoptotic agent. Once considered an inert gas, it reveals current
therapeutic potential among others in inflammatory diseases, cancer, and sports medicine,
among others. The present review aims to provide a consistent summary of the findings
of the last twenty years on the use of molecular hydrogen in
Hypothesis
MHID-2190797PMID: 409385202025Intensive Care Medicine Experimental
Lakhmir S. Chawla
Molecular hydrogen gas (HG), administered through inhalation or as hydrogen-rich fluids (HRF), has demonstrated antioxidant, anti-inflammatory, antiapoptotic, cytoprotective, and beneficial mitochondrial effects in critical illness. Preclinical studies and human clinical studies consistently endorse hydrogen gas as safe, with mechanisms of action linked to vital molecular pathways, such as reducti
In SilicoHypothesisHighlighted
MHID-3775261PMID: 398291632025Medical Gas Research
Grace Russell
Hydrogen (H2), the simplest and most ubiquitous molecule in the universe, has garnered significant scientific interest over the past two decades because of its potential as an effective antioxidant and anti-inflammatory agent. Traditionally considered inert, H2 is now being re-evaluated for its unique bioactive properties. H2 selectively neutralizes reactive oxygen and nitrogen species, mitigating
