Clinical TrialHighlighted
MHID-9166764PMID: 408269302025Medical Gas Research
Yu Hong Gao, Jun Chen, Hua Zhong, Qiang Zhao
Sleep disorders are associated with various chronic diseases. While hydrogen has anti-inflammatory, antioxidant, and antifibrotic effects and has potential applications in disease management, its impact on sleep disorders remains unclear. This single-blind, randomized controlled clinical trial from September 2022 to July 2023 at the Second Medical Center of the PLA General Hospital and the Affilia
Animal StudyHighlighted
MHID-5834617PMID: 398578172025Biomedicines
Masaki Shibuya, Masafumi Fujinaka, Mako Yonezawa, Natsumi Nishimura, Hitoshi Uchinoumi, Hiroshi Sunahara, et al.
Background: Hydrogen gas (H2) has been shown to be effective in the treatment of various clinical conditions, from acute illnesses to chronic illnesses. However, its clinical indications and the corresponding appropriate hydrogen delivery methods have yet to be determined. This is due to the fact that the pharmacokinetics and pharmacodynamics of hydrogen in each delivery method have not been exper
Animal StudyIn VitroHighlighted
MHID-7283969PMID: 417999532025Materials Today Bio
Chunru Kong, Chao Si, Haofeng Liu, Yawen Wang, Jiakai Qiao, Xiaoduo Tang, et al.
The repair of infected bone defects (IBDs) presents a significant clinical challenge due to recurrent infections and
inflammation. Characterized by reactive oxygen species (ROS) bursts and mitochondrial dysfunction, IBDs
generates to a vicious oxidation-inflammation cycle that impairs bone remodeling. To address this, we developed
a double-network hydrogel scaffold composed of phenylboronic acid-m
Literature ReviewObservational StudyHighlighted
MHID-3682903PMID: 411676902025IN VIVO
YOU‐CHI REN, JENG‐WEI LU, YI‐JUNG HO, SHAN‐WEN LUI, TING‐YU HSIEH, KUANG‐YIH WANG, et al.
Background/Aim: Rheumatoid arthritis (RA) is a chronic autoimmune disease affecting synovial joints, often causing
to joint destruction and systemic comorbidities. Cervical spine involvement, especially atlantoaxial subluxation (AAS),
can lead to spinal cord compression and neurological deficits. While disease‑modifying antirheumatic drugs (DMARDs)
are standard therapy, intolerance to agents like
Clinical TrialHighlighted
MHID-1036598PMID: 399231332025Medical Gas Research
Pavel Grepl, Michal Botek, Jakub Krejčí, Andrew McKune
Initially, molecular hydrogen was considered a physiologically inert and non-functional gas. However, experimental and clinical studies have shown that molecular hydrogen has anti-inflammatory, anti-apoptotic, and strong selective antioxidant effects. This study aimed to evaluate the effects of 60 minutes of molecular hydrogen inhalation on respiratory gas analysis parameters using a randomized, d
Animal StudyIn VitroHighlighted
MHID-1674678PMID: 407251672025International Journal of Molecular Sciences
Sofian Abdul-Nasir, Cat Tuong Chau, Tien Thuy Nguyen, Johny Bajgai, Md. Habibur Rahman, Kwon Hwang-Un, et al.
Alzheimer’s disease (AD) is a neurodegenerative condition in which amyloid-beta (Aβ) plaques trigger oxidative stress (OS) and neuroinflammation, causing memory loss. OS and neurodegeneration can also be caused by reactive astrocytes, thereby promoting AD via toxic metabolite accumulation in the astrocytic urea cycle. However, the effect of molecular hydrogen (H2) on this cycle remains unknown. Th
Literature Review
MHID-3242181PMID: 405693542025Molecular Biology Reports
Yong Ye, Zi-hang Yu, Liang Nie, Bin Lu, Guo Mu
Pyroptosis, a highly inflammatory programmed cell death pathway, drives pathogenesis in numerous diseases through gasdermin-mediated membrane pore formation and massive cytokine release. While conventional anti-inflammatory therapies show limited efficacy, hydrogen emerges as a novel therapeutic agent with unique pyroptosis-regulatory capabilities. This review establishes a comprehensive mechanist
Literature Review
MHID-2276724PMID: 400610442025Clinical, Cosmetic and Investigational Dermatology
Nan Guo, Yating Zhang
Molecular hydrogen is a colorless, tasteless, biologically active small-molecule gas with reducing properties, demonstrating therapeutic and preventive effects across various human systems. Its mechanisms of action include selective antioxidation, anti- inflammatory effects, apoptosis inhibition, and the regulation of gene expression and signaling pathways. In the skin, molecular hydrogen reduces
Animal StudyIn VitroHighlighted
MHID-4061148PMID: 406876592025Translational Andrology and Urology
Qijie Chen, Shaoqing Yu, Yating Pan, Hong Tang, Yang Wang, Ninghan Feng, et al.
Background: Diabetes mellitus (DM) is a chronic metabolic disorder characterized by persistent hyperglycemia, leading to severe systemic complications and reduced quality of life. Current therapies often fail to comprehensively alleviate diabetic complications, highlighting the need for novel approaches. Animal studies and clinical trials have demonstrated the therapeutic potential of molecular hy
Literature ReviewHighlighted
MHID-0845802PMID: 399115282025Biochemistry and Biophysics Reports
Fatmanur Yıldız, Tyler W. LeBaron, Duried Alwazeer
Oxidative stress is responsible for the pathogenesis of many diseases, and antioxidants are commonly included in their treatment protocols. Over the past two decades, numerous biomedical reports have revealed the therapeutic benefits of molecular hydrogen (H2) in relieving oxidation-related diseases. H2 has been found to have selective antioxidant properties against the most dangerous oxidants (hy
Animal StudyHighlighted
MHID-0413972PMID: 401127282025Food Chemistry
Hilal Kanmaz, Didem Şahingil, Duried Alwazeer, Menekşe Bulut, Mushap Kuru, Mustafa Makav, et al.
This study aimed to investigate the effects of hydrogen-rich water (HRW) consumption in goats on the chemical composition, antioxidant activity, total phenolic content, in vitro antidiabetic activity (α-amylase and α-glucosidase inhibitions), free fatty acid profile, and volatile compounds of colostrum and mature milk. Goats were fed ad libitum with either normal water (NW) or HRW for 20–22 days b
Animal StudyEx VivoHighlighted
MHID-4421003PMID: 398164752025Bioactive Materials
Yuanming An, Haozhi Zhang, Shi’an Zhang, Yuantao Zhang, Lizhen Zheng, Xin Chen, et al.
Biodegradable magnesium (Mg) implant generally provides temporary fracture fixation and facilitates bone regeneration. However, the exact effects of generated Mg ions (Mg2+), hydrogen gas (H2), and hydroxide ions (OH-) by Mg degradation on enhancing fracture healing are not fully understood. Here we investigate the in vivo degradation of Mg intramedullary nail (Mg-IMN), revealing the generation of
Animal StudyIn VitroEx VivoHighlighted
MHID-9370665PMID: 404119852025Biomaterials
Yuanming An, Lizhen Zheng, Shi’an Zhang, Haozhi Zhang, Yuantao Zhang, Hongwei Shao, et al.
Steroid-associated osteonecrosis (SAON) remains a challenging clinical condition as there are few effective preventive measures. This study investigates the effects of hydrogen (H2) administrated via saturated hydrogen-rich water (HRW) in mice received high dose of glucocorticoids (for inducing SAON model). Here we find that HRW treatment significantly reduces osteocyte apoptosis, improves deterio
MHID-68795282025Journal of Hypertension
Kuropatkina, Tatyana, Artemieva, Marina, Kozaeva, Larisa, Medvedeva, Natalia, Medvedev, Oleg
Objective:The aim of the study was to investigate the effects of intermittent inhalation of H2 on possible mechanisms of sympathetic involvement in the regulation of systemic blood pressure in experiments using an in vivo model of monocrotaline-induced pulmonary hypertension.
Design and method: Wistar males (180-220 g) were injected subcutaneously with monocrotaline (MCT) (60 mg/kg in 60% C2H5OH)
Animal StudyHighlighted
MHID-5192112PMID: 407333742025Plants
Longna Li, Jiaxin Gong, Ke Jiang, Liqin Huang, Lijun Gan, Yan Zeng, et al.
Fruit yield and quality improvement are challenges for researchers and farmers. This study reveals that the main fruit traits of blueberry (Vaccinium ashei ‘Bluegem’) were significantly improved after hydrogen (H2)-based irrigation, assessed by the increased single fruit weight (14.59 ± 6.66%) and fruit equatorial diameter (4.19 ± 2.39%), decreased titratable acidity, increased solid–acid and suga
In SilicoHighlighted
MHID-6447318PMID: 410089612025Antioxidants
Sumaiya Akhter Ria, Jintana Meesungnoen, Jean-Paul Jay-Gerin
(1) Background: Water, comprising about 70–80% of cellular mass, is the most abundant constituent of living cells. Upon exposure to ionizing radiation, water undergoes radiolysis, generating a variety of reactive species, including free radicals and molecular products. Among these, hydroxyl radicals (•OH) are particularly damaging due to their very high reactivity and their capacity to induce oxid
Animal StudyHighlighted
MHID-15287492025Bratislava Medical Journal
Miktat Kaya, Mustafa Makav, Ebru Karadağ Sarı, Şükran Yediel Aras, Mushap Kuru, Abdussamed Vural, et al.
The aim of the study was to investigate the therapeutic efficacy of hydrogen-rich water in pentylenetetrazol-induced epilepsy. A total of 30 female rats, 6 animals in each group, were used in the study. All groups except the control group were ovariec- tomized. Hydrogen-rich water Group (HRW) and Epilepsy + HRW Group (E + HRW) were administered intraperitoneally for 14 days. On the 14th day of the
Literature ReviewHighlighted
MHID-46251652025Modern Agriculture
Yu Dai
Hydrogen has emerged as a pivotal element poised to revolutionise agricultural technology. Its demonstrated potential to enhance soil quality, stimulate crop growth, and elevate agricultural productivity has garnered substantial scientific interest. This paper examines the historical evolution and contemporary applications of hydrogen in agriculture, analyses future prospects and challenges, and u
MHID-5646200PMID: 414496522025Respiratory care
Nguyen Puente B, Habet V, Wheeler CR, Kheir JN.
Molecular hydrogen (H2) has emerged as a promising therapeutic agent with potential applications across a wide range of conditions, including neurological, cardiovascular, oncologic, and respiratory diseases. Substantial preclinical studies attribute its benefits to selective antioxidant, anti-inflammatory, and cytoprotective properties. Published clinical findings are encouraging, although data a
Animal StudyIn VitroHighlighted
MHID-8939519PMID: 413302172025Redox Biology
Shuto Negishi, Mikako Ito, Tomoya Hasegawa, Hikaru Otake, Bisei Ohkawara, Akio Masuda, et al.
The mechanisms underlying the biomedical effects of molecular hydrogen (H2) remain poorly understood and
are often attributed to its selective reduction of hydroxyl radicals, based on the long-held notion that H2 is
biologically inert. We demonstrate that H2 is biologically active, specifically targeting the Rieske iron-sulfur
protein (RISP). We first observed that H2 induces the mitochondrial unf
