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Animal StudyHighlighted

Oral intake of hydrogen water improves retinal blood flow dysregulation in response to flicker stimulation and systemic hyperoxia in diabetic mice

MHID-3103887PMID: 394463622024Translational Vision Science & Technology

Ruri Sugiyama, Junya Hanaguri, Harumasa Yokota, Akifumi Kushiyama, Sakura Kushiyama, Takako Kikuchi, et al.

Purpose: To examine the effects of hydrogen water on retinal blood flow (RBF) dysregulation in diabetes, we evaluated changes in RBF in response to flicker stimulation and systemic hyperoxia in diabetic mice. Methods: Twelve type 2 diabetic mice were divided into a group that received non-hydrogen water (n = 6, control group) and the other that received hydrogen-rich water (0.6–0.8 mM) (n = 6, HR

Animal StudyIn VitroHighlighted

Molecular hydrogen ameliorates several characteristics of preeclampsia in the Reduced Uterine Perfusion Pressure (RUPP) rat model

MHID-8667127PMID: 277892932016Free Radical Biology and Medicine

Takafumi Ushida, Tomomi Kotani, Hiroyuki Tsuda, Kenji Imai, Tomoko Nakano, Shima Hirako, et al.

Oxidative stress plays an important role in the pathogenesis of preeclampsia. Recently, molecular hydrogen (H2) has been shown to have therapeutic potential in various oxidative stress-related diseases. The aim of this study is to investigate the effect of H2 on preeclampsia. We used the reduced utero-placental perfusion pressure (RUPP) rat model, which has been widely used as a model of preeclamps