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Animal Study

Dissolved molecular hydrogen (H2) in Peritoneal Dialysis (PD) solutions preserves mesothelial cells and peritoneal membrane integrity

MHID-5925679PMID: 290890292017BMC Nephrology

Masaaki Nakayama, Wan-Jun Zhu, Kimio Watanabe, Ayano Gibo, Ali M. Sherif, Shigeru Kabayama, et al.

Background: Peritoneal dialysis (PD) is used as renal replacement therapy in patients with end-stage kidney disease. However, peritoneal membrane failure remains problematic and constitutes a critical cause of PD discontinuation. Recent studies have revealed the unique biological action of molecular hydrogen (H2) as an antioxidant, which ameliorates tissue injury. In the present study, we aimed to

Animal StudyHighlighted

Hydrogen-Rich Saline Alleviates Kidney Fibrosis Following AKI and Retains Klotho Expression

MHID-3260346PMID: 288484322017Frontiers in Pharmacology

Jing Chen, Han Zhang, Jiachang Hu, Yulu Gu, Ziyan Shen, Linghan Xu, et al.

Purpose: Acute kidney injury (AKI) is a prominent risk factor for the development of chronic kidney disease (CKD). To date, the related mechanism and effective therapy have not been rigorously explored. The present study aims to investigate the reno- protection of hydrogen-rich saline (HRS) against ischemia/reperfusion (IR)-induced AKI. Methods: Adult male C57 mice were randomly allocated into th