Observational StudyHighlightedAn H2-infused, nitric oxide-producing functional beverage as a neuroprotective agent for TBIs and concussionsMHID-6285582PMID: 346451002021Journal of Integrative NeuroscienceTyler W. LeBaron, Jason Kharman, Michael L. McCulloughTraumatic brain injuries (TBIs) are a leading cause of death and dis- ability. Sports-related TBIs are estimated to be more than several million per year. The pathophysiology of TBIs involves high levels of inflammation, oxidative stress, dysregulation of ion homeosta- sis, mitochondrial dysfunction, and apoptosis. There is also a reduc- tion in cerebral blood flow, leading to hypoxia and reduced
Animal StudyMolecular Hydrogen in Drinking Water Protects against Neurodegenerative Changes Induced by Traumatic Brain InjuryMHID-0185761PMID: 252512202014PLoS ONEKenji Dohi, Brian C. Kraemer, Michelle A. Erickson, Pamela J. McMillan, Andrej Kovac, Zuzana Flachbartova, et al.Traumatic brain injury (TBI) in its various forms has emerged as a major problem for modern society. Acute TBI can transform into a chronic condition and be a risk factor for neurodegenerative diseases such as Alzheimer’s and Parkinson’s diseases, probably through induction of oxidative stress and neuroinflammation. Here, we examined the ability of the antioxidant molecular hydrogen given in drink