Animal StudyIn VitroHighlightedSonocatalytic hydrogen/hole-combined therapy for anti-biofilm and infected diabetic wound healingMHID-3225760PMID: 370564242023National Science ReviewQingqing Xu, Shengqiang Chen, Lingdong Jiang, Chao Xia, Lingting Zeng, Xiaoqing Cai, et al.It is a great challenge to effectively eradicate biofilm and cure biofilm-infected diseases because dense extracellular polymeric substance matrix prevents routine antibacterial agents from penetrating into biofilm. H2 is an emerging energy-regulating molecule possessing both high biosafety and high tissue permeability. In this work, we propose a concept of sonocatalytic hydrogen/hole-combined ‘in