Clinical TrialAnimal StudyHighlighted
MHID-3437190PMID: 391167822024Biomedicine & Pharmacotherapy
Bing Xie, Yong Wang, Yun Lu, Mengmeng Wang, Rongji Hui, Hailei Yu, et al.
The gut-brain axis mediates the interaction pathway between microbiota and opioid addiction. In recent years, many studies have shown that molecular hydrogen has therapeutic and preventive effects on various diseases. This study aimed to investigate whether molecular hydrogen could serve as pharmacological intervention agent to reduce risks of reinstatement of opioid seeking and explore the mechan
Animal Study
MHID-6003573PMID: 364684152023CNS Neuroscience & Therapeutics
Qingqing Han, Yuanyuan Bai, Chunjing Zhou, Beibei Dong, Yingning Li, Ning Luo, et al.
Introduction: In our experiments, male wild-type mice were randomly divided into four groups: the sham, SAE, SAE + 2% hydrogen gas inhalation (H2), and SAE + hydrogen-rich water (HW) groups. The feces of the mice were collected for 16 S rDNA analysis 24 h after the models were established, and the serum and brain tissue of the mice were collected for nontargeted metabolomics analysis.
Aim: Destru
Animal Study
MHID-4869388PMID: 316002562019PLoS ONE
Laura Bordoni, Rosita Gabbianelli, Donatella Fedeli, Dennis Fiorini, Ina Bergheim, Cheng Jun Jin, et al.
There is growing awareness within the scientific community of the strong connection between the inflammation in the intestine and the pathogenesis of Parkinson’s disease (PD). In previous studies we developed a PD animal model exposing pup rats to permethrin (PERM) pesticide. Here, we intended to explore whether in our animal model there were changes in gut permeability, fecal microbiota and hepat
