Animal StudyIn VitroHighlightedA H2-bioreactor for mitochondrial rehabilitation in infected bone defects regenerationMHID-7283969PMID: 417999532025Materials Today BioChunru Kong, Chao Si, Haofeng Liu, Yawen Wang, Jiakai Qiao, Xiaoduo Tang, et al.The repair of infected bone defects (IBDs) presents a significant clinical challenge due to recurrent infections and inflammation. Characterized by reactive oxygen species (ROS) bursts and mitochondrial dysfunction, IBDs generates to a vicious oxidation-inflammation cycle that impairs bone remodeling. To address this, we developed a double-network hydrogel scaffold composed of phenylboronic acid-m