Animal StudyIn VitroHighlightedSequential hydrogen-release implant for promoting the soft tissue integration through immunomodulatory and pro-remodeling couplingMHID-5401653PMID: 413343742026Bioactive MaterialsYue Yuan, Zishuo Hou, Miaomiao Chen, Jingwei Yu, Minghao Zhou, Jiaxin Kang, et al.The weaker soft tissue integration around implants compared to natural teeth poses a substantial challenge to the long-term success of implants. To enhance soft tissue integration, we develop an on-demand and long-lasting H2-releasing implant to achieve precise sequential regulation of the soft tissue integration through immunomodulation and pro-remodeling coupling. In the inflammatory phase, the
Animal StudyIn VitroEx VivoHighlightedPhotocatalytic glucose depletion and hydrogen generation for diabetic wound healingMHID-2989698PMID: 361678142022Nature CommunicationsShengqiang Chen, Yanxia Zhu, Qingqing Xu, Qi Jiang, Danyang Chen, Ting Chen, et al.High-glucose microenvironment in the diabetic foot ulcer (DFU) causes excessive glycation and induces chronic inflammation, leading to the difficulty of DFU healing. Hydrogen-rich water bath can promote the healing of DFU in clinic by virtue of the anti-inflammatory effect of hydrogen molecules, but the long-term daily soaking counts against the formation of a scab and cannot change the high-glucose
