Animal StudyIn VitroEx VivoHighlightedHydrogen activates ACOD1-itaconate pathway to ameliorate steroid-associated osteonecrosisMHID-9370665PMID: 404119852025BiomaterialsYuanming An, Lizhen Zheng, Shi’an Zhang, Haozhi Zhang, Yuantao Zhang, Hongwei Shao, et al.Steroid-associated osteonecrosis (SAON) remains a challenging clinical condition as there are few effective preventive measures. This study investigates the effects of hydrogen (H2) administrated via saturated hydrogen-rich water (HRW) in mice received high dose of glucocorticoids (for inducing SAON model). Here we find that HRW treatment significantly reduces osteocyte apoptosis, improves deterio
