Animal StudyIn VitroHighlightedMechanism by which hydrogen-rich water mitigates exercise-induced fatigue: activation of the immunoresponsive gene 1-itaconate/nuclear factor erythroid 2-related factor 2/heme oxygenase-1 pathwayMHID-1663779PMID: 405801852026Medical Gas ResearchYinyin Zhang, Yajing Ying, Xianpeng Zu, Lingling Ding, Xuan Shi, Jing Wang, et al.Exercise-induced fatigue limits athletic performance. Molecular hydrogen is an effective treatment for relieving fatigue, but the exact mechanism is not clear. In our study, a mouse model of fatigue was established to explore the molecular mechanism by which hydrogen-rich water reduces exercise-induced fatigue. The results showed that hydrogen-rich water improved the motor function of fatigue mice
Animal StudyIn VitroHighlightedMolecular hydrogen inhibits lipopolysaccharide/interferon c-induced nitric oxide production through modulation of signal transduction in macrophagesMHID-1458727PMID: 217232542011Biochemical and Biophysical Research CommunicationsTomohiro Itoh, Nanako Hamada, Riyako Terazawa, Mikako Ito, Kinji Ohno, Masatoshi Ichihara, et al.Molecular hydrogen has been reported to be effective for a variety of disorders and its effects have been ascribed to the reduction of oxidative stress. However, we have recently demonstrated that hydrogen inhibits type I allergy through modulating intracellular signal transduction. In the present study, we examined the hydrogen effects on lipopolysaccharide/interferon c LPS/IFNc-induced nitric ox
