Animal StudyHydrogen-containing saline alleviates pressure overload-induced interstitial fibrosis and cardiac dysfunction in ratsMHID-0745319PMID: 286562162017Molecular Medicine ReportsJing Yang, Shujing Wu, Liqun Zhu, Jingjing Cai, Lu FuCardiac fibrosis induced by sustained pressure overload contributes to heart failure. Oxidative stress serves an important role in cardiac remodeling and heart failure independent of etiological factors. The application of hydrogen as an antioxidant is a novel concept in disease treatment, however no studies as present have investigated the effects of hydrogen on cardiac fibrosis. In the present s
Animal StudyHighlightedSimultaneous oral and inhalational intake of molecular hydrogen additively suppresses signaling pathways in rodentsMHID-5889693PMID: 257075802015Molecular and Cellular BiochemistrySayaka Sobue, Kazuaki Yamai, Mikako Ito, Kinji Ohno, Masafumi Ito, Takashi Iwamoto, et al.Molecular hydrogen (H2) is an agent with po- tential applications in oxidative stress-related and/or in- flammatory disorders. H2 is usually administered by inhaling H2-containing air (HCA) or by oral intake of H2- rich water (HRW). Despite mounting evidence, the mole- cular mechanism underlying the therapeutic effects and the optimal method of H2 administration remain unclear. Here, we investigate
