In VitroHighlightedMolecular hydrogen protects against oxidative stress‑induced RAW 264.7 macrophage cells through the activation of Nrf2 and inhibition of MAPK signaling pathwayMHID-35801392020Molecular & Cellular ToxicologyRahima Begum, Cheol‑Su Kim, Ailyn Fadriquela, Johny Bajgai, Xingyu Jing, Dong‑Heui Kim, et al.Background: Oxidative stress is involved in the development of many inflammatory, metabolic and aging diseases. Objective: In this study we investigated, the protective effects of H2 on RAW 264.7 macrophage cell against LPS-and H2O2-induced oxidative stress by the inhibition of MAPK pathway and also activate the Nrf2 pathway. Results: Our results showed H2 increased the macrophage cell prolifera
In VitroHighlightedMolecular Hydrogen Protects Human Melanocytes from Oxidative Stress by Activating Nrf2 SignalingMHID-7135279PMID: 345586532020Journal of Investigative DermatologyWei Fang, Luyan Tang, Guizhen Wang, Jinran Lin, Wanqing Liao, Weihua Pan, et al.Oxidative stress is proven to be critical for the initiation and progression of vitiligo. Molecular hydrogen (H2) possesses potent antioxidant activity and has been shown to protect against various oxidative stresserelated diseases. In this study, we first investigated the effects and mechanisms of H2 in human melanocytes damaged by hydrogen peroxide. We initially found that H2 reduced intracellula
