Animal StudyHighlightedSimultaneous oral and inhalational intake of molecular hydrogen additively suppresses signaling pathways in rodentsMHID-5889693PMID: 257075802015Molecular and Cellular BiochemistrySayaka Sobue, Kazuaki Yamai, Mikako Ito, Kinji Ohno, Masafumi Ito, Takashi Iwamoto, et al.Molecular hydrogen (H2) is an agent with po- tential applications in oxidative stress-related and/or in- flammatory disorders. H2 is usually administered by inhaling H2-containing air (HCA) or by oral intake of H2- rich water (HRW). Despite mounting evidence, the mole- cular mechanism underlying the therapeutic effects and the optimal method of H2 administration remain unclear. Here, we investigate
Animal StudyHighlightedProfiling molecular changes induced by hydrogen treatment of lung allografts prior to procurementMHID-09896642012Biochemical and Biophysical Research CommunicationsYugo Tanaka, Norihisa Shigemura, Tomohiro Kawamura, Kentaro Noda, Kumiko Isse, Donna Beer Stolz, et al.Background—We previously demonstrated that donor treatment with inhaled hydrogen protects lung grafts from cold ischemia/reperfusion (I/R) injury during lung transplantation. To elucidate the mechanisms underlying hydrogen’s protective effects, we conducted a gene array analysis to identify changes in gene expression associated with hydrogen treatment. Methods—Donor rats were exposed to mechanica
