Animal StudyHighlightedSimultaneous oral and inhalational intake of molecular hydrogen additively suppresses signaling pathways in rodentsMHID-5889693PMID: 257075802015Molecular and Cellular BiochemistrySayaka Sobue, Kazuaki Yamai, Mikako Ito, Kinji Ohno, Masafumi Ito, Takashi Iwamoto, et al.Molecular hydrogen (H2) is an agent with po- tential applications in oxidative stress-related and/or in- flammatory disorders. H2 is usually administered by inhaling H2-containing air (HCA) or by oral intake of H2- rich water (HRW). Despite mounting evidence, the mole- cular mechanism underlying the therapeutic effects and the optimal method of H2 administration remain unclear. Here, we investigate
Animal StudyHighlightedEffects of hydrogen‑rich saline on early acute kidney injury in severely burned rats by suppressing oxidative stress induced apoptosis and inflammationMHID-4748086PMID: 260479402015Journal of Translational MedicineSong‑Xue Guo, Quan Fang, Chuan‑Gang You, Yun‑Yun Jin, Xin‑Gang Wang, Xin‑Lei Hu, et al.Background: Early acute kidney injury (AKI) in severely burned patients predicts a high mortality that is multi-factorial. Hydrogen has been reported to alleviate organ injury via selective quenching of reactive oxygen species. This study investigated the potential protective effects of hydrogen against severe burn-induced early AKI in rats. Methods: Severe burn were induced via immersing the sha
