Animal StudyHighlightedMolecular hydrogen mitigates acetaminophen-induced liver injury and enhances the effects of N-acetylcysteine in diabetic miceMHID-6449583PMID: 412075402026Journal of Nutritional BiochemistryNaomi Kamimura, Katsuya Iuchi, Tsutomu Igarashi, Ikuroh Ohsawa, Chikako Nito, Jitsuo Usuda, et al.Acetaminophen (APAP) overdose induces severe liver injury, especially in diabetic patients. N -acetylcysteine (NAC) is commonly used as an approved an- tidote for APAP toxicity; however, its narrow therapeutic window limits its clinical utility. This study investigated the protective effects of molecular hydro- gen (H2 ) against APAP-induced hepatotoxicity in diabetic mice. Diabetic db/db mice wer
Clinical TrialIn VitroObservational StudyHighlightedAlpha Hope, via Molecular Hydrogen and Pyrroloquinoline Quinone, Dose-Dependently Increases Nrf2 and PGC-1α Levels in C2C12 MyoblastsMHID-30414712023ProcessesRichard J. Bloomer, Yufeng Zhang, Joshua Y. Shirazi, Chidimma Okegbe, Jacquelyn Pence, Keith Martin, et al.Alpha Hope is a dietary supplement containing pyrroloquinoline quinone and elemental magnesium, which produces molecular hydrogen (H2 gas) when dissolved in water. We determined the impact of Alpha Hope on Nrf-2, peroxisome proliferator-activated receptor-gamma coactivator (PGC-1α), and citrate synthase (CS) activity in C2C12 myoblasts. Alpha Hope was titrated to three concentrations of pyrroloqui
