Animal StudyIn VitroHighlightedHydrogen Gas Attenuates Toxic Metabolites and Oxidative Stress-Mediated Signaling to Inhibit Neurodegeneration and Enhance Memory in Alzheimer’s Disease ModelsMHID-1674678PMID: 407251672025International Journal of Molecular SciencesSofian Abdul-Nasir, Cat Tuong Chau, Tien Thuy Nguyen, Johny Bajgai, Md. Habibur Rahman, Kwon Hwang-Un, et al.Alzheimer’s disease (AD) is a neurodegenerative condition in which amyloid-beta (Aβ) plaques trigger oxidative stress (OS) and neuroinflammation, causing memory loss. OS and neurodegeneration can also be caused by reactive astrocytes, thereby promoting AD via toxic metabolite accumulation in the astrocytic urea cycle. However, the effect of molecular hydrogen (H2) on this cycle remains unknown. Th
Clinical TrialHighlightedMolecular hydrogen modulates brain glutamate/GABA-glutamine cycle in overweight humansMHID-5537085PMID: 375607462023Archives of Medical ScienceDarinka Korovljev, Jelena Ostojic, Nikola Todorovic, Sergej M OstojicIntroduction: We evaluated whether 12-week intake of molecular hydrogen (H2) in 5 overweight adults (3 women; age: 50.2 ±11.9 years, body mass index: 29.4 ±2.1 kg/m2) affects brain levels of the glutamate-glutamine-GABA cycle, critical amino acid neurotransmitters in the mechanism of neuronal activation during appetite regulation. Methods: A 1.5-T single-voxel proton magnetic resonance spectrosco