Animal StudyIn VitroHighlightedSequential hydrogen-release implant for promoting the soft tissue integration through immunomodulatory and pro-remodeling couplingMHID-5401653PMID: 413343742026Bioactive MaterialsYue Yuan, Zishuo Hou, Miaomiao Chen, Jingwei Yu, Minghao Zhou, Jiaxin Kang, et al.The weaker soft tissue integration around implants compared to natural teeth poses a substantial challenge to the long-term success of implants. To enhance soft tissue integration, we develop an on-demand and long-lasting H2-releasing implant to achieve precise sequential regulation of the soft tissue integration through immunomodulation and pro-remodeling coupling. In the inflammatory phase, the
In VitroHighlightedMolecular Hydrogen Protects Human Melanocytes from Oxidative Stress by Activating Nrf2 SignalingMHID-7135279PMID: 345586532020Journal of Investigative DermatologyWei Fang, Luyan Tang, Guizhen Wang, Jinran Lin, Wanqing Liao, Weihua Pan, et al.Oxidative stress is proven to be critical for the initiation and progression of vitiligo. Molecular hydrogen (H2) possesses potent antioxidant activity and has been shown to protect against various oxidative stresserelated diseases. In this study, we first investigated the effects and mechanisms of H2 in human melanocytes damaged by hydrogen peroxide. We initially found that H2 reduced intracellula
