In SilicoHighlighted
MHID-6447318PMID: 410089612025Antioxidants
Sumaiya Akhter Ria, Jintana Meesungnoen, Jean-Paul Jay-Gerin
(1) Background: Water, comprising about 70–80% of cellular mass, is the most abundant constituent of living cells. Upon exposure to ionizing radiation, water undergoes radiolysis, generating a variety of reactive species, including free radicals and molecular products. Among these, hydroxyl radicals (•OH) are particularly damaging due to their very high reactivity and their capacity to induce oxid
In VivoHighlighted
MHID-2254695PMID: 396409892024Frontiers in Plant Science
Renyuan Wang, Xijia Yang, Yaowei Chi, Xia Zhang, Xianzhong Ma, Dan Zhang, et al.
Salt stress could lead to plant growth barriers and crop yield reduction. Strawberries are sensitive to salt stress, and improving salt tolerance is important for strawberry production. This study aimed to explore the potential of hydrogen-rich water (HRW) to enhance salt tolerance in strawberries. Through pot experiments, we investigated how HRW affects plant growth, ion absorption, osmotic stres
In Vitro
MHID-0313161PMID: 340286462021Molecular and Cellular Biochemistry
Yasukazu Saitoh, Yuuki Yamaguchi, Yuhei Okada
Molecular hydrogen (H2) is recognized as a gaseous antioxidant, and it is expected to ameliorate various disorders related to oxidative stress and inflammation. However, there are still many unclear points regarding its effectiveness in the skin. Therefore, the purpose of this study was to examine the protective effect of H2 against ultraviolet (UV) irradiation-related stress injury in human epide
Plant StudyHighlighted
MHID-6657679PMID: 230947982012Plant, Cell and Environment
Qijiang Jin, Weiti Cui, Bin Han, Yanjie Xie, Kaikai Zhu, Wenbiao Shen
Hydrogen gas (H2) was recently proposed as a novel antioxidant and signalling molecule in animals. However, the physiological roles of H2 in plants are less clear. Here, we showed that exposure of alfalfa seedlings to paraquat stress increased endogenous H2 production. When supplied with exogenous H2 or the heme oxygenase-1 (HO-1)-inducer hemin, alfalfa plants displayed enhanced tolerance to oxida
Animal StudyIn Vitro
MHID-5661317PMID: 223730562011BMC Proceedings
Sanetaka Shirahata, Takeki Hamasaki, Keisuke Haramaki, Takuro Nakamura, Masumi Abe, Hanxu Yan, et al.
Electrochemically reduced water (ERW) contains a lot of hydrogen molecule (H2) and scavenges reactive oxygen species (ROS) to protect DNA from oxidative damage [1]. ERW also contains small amounts of Pt nanoparticles (NPs) and elongates the lifespan of C. elegans [2]. Pt NPs are newly recognized multi-functional ROS scavengers [3]. ERW exhibits anti-diabetes effects in vitro and in vivo [4-6][7].
Animal StudyIn VitroHighlighted
MHID-7700658PMID: 174860892007Nature Medicine
Ikuroh Ohsawa, Masahiro Ishikawa, Kumiko Takahashi, Megumi Watanabe, Kiyomi Nishimaki, Kumi Yamagata, et al.
Acute oxidative stress induced by ischemia-reperfusion or inflammation causes serious damage to tissues, and persistent oxidative stress is accepted as one of the causes of many common diseases including cancer. We show here that hydrogen (H2) has potential as an antioxidant in preventive and therapeutic applications. We induced acute oxidative stress in cultured cells by three independent methods.
