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HypothesisOpinion PieceHighlighted

Role of molecular hydrogen in obesity treatment: modulation of GLP-1, irisin, and PGC-1α for improved metabolism

MHID-6155704PMID: 402510252025Medical Gas Research

Nikola Todorovic, Jovan Kuzmanovic, Dejan Javorac, Sergej M Ostojic

The increasing prevalence of obesity and non-communicable diseases has become a major global health concern, contributing to significant morbidity and mortality rates. These conditions not only burden healthcare systems but also affect the individual’s quality of life worldwide. As these challenges continue to grow, there is a pressing need to explore treatment options that are effective, affordab

Clinical TrialHighlighted

Health Effects of Electrolyzed Hydrogen Water for the Metabolic Syndrome and Pre-Metabolic Syndrome: A 3-Month Randomized Controlled Trial and Subsequent Analyses

MHID-2861044PMID: 383977432024Antioxidants

Reiko Moribe, Marina Minami, Ryoji Hirota, Naw Awn J-P, Shigeru Kabayama, Masamitsu Eitoku, et al.

We studied the effect of three months’ use of electrolyzed hydrogen water (EHW, Elec- trolyzed Hydrogen Water conditioner produced by Nihon Trim Co., Ltd.) on metabolic and pre- metabolic syndrome groups. This research was carried out jointly by Susaki City; Nihon Trim Co., Ltd.; and Kochi University as part of a local revitalization project with health as a keyword. A ran- domized, placebo-contro

Observational StudyHighlighted

Evaluation of the safety and potential lipid-lowering effects of oral hydrogen-rich coral calcium (HRCC) capsules in patients with metabolic syndrome: a prospective case series study

MHID-0293642PMID: 375214102023Frontiers in Nutrition

Szu-Han Chiu, Frank L. Douglas, Jia-Ru Chung, Kuang-Yih Wang, Chao-Fang Chu, Hsia-Yun Chou, et al.

Background: Metabolic syndrome is characterized by a cluster-like occurrence of conditions such as hypertension, hyperglycaemia, elevated low-density lipoprotein (LDL) cholesterol or triglycerides (TG) and high visceral fat. Metabolic syndrome is linked to the build-up of plaque within the artery, which leads to disorders of the circulatory, nervous and immune systems. A variety of treatments targ

Clinical TrialHighlighted

The Effects of 24-Week, High-Concentration Hydrogen-Rich Water on Body Composition, Blood Lipid Profiles and Inflammation Biomarkers in Men and Women with Metabolic Syndrome: A Randomized Controlled Trial

MHID-5701846PMID: 322737402020Diabetes, Metabolic Syndrome and Obesity

Tyler W. LeBaron, Ram B. Singh, Ghizal Fatima, Kumar Kartikey, Jagdish P Sharma, Sergej M Ostojic, et al.

Purpose: Metabolic syndrome is associated with several medical risk factors including dyslipidemia, hyperglycemia, and obesity, which has become a worldwide pandemic. The sequelae of this condition increase the risk of cardiovascular and neurological disease and increased mortality. Its pathophysiology is associated with redox dysregulation, excessive inflammation, and perturbation of cellular hom