Observational StudyHighlightedAn H2-infused, nitric oxide-producing functional beverage as a neuroprotective agent for TBIs and concussionsMHID-6285582PMID: 346451002021Journal of Integrative NeuroscienceTyler W. LeBaron, Jason Kharman, Michael L. McCulloughTraumatic brain injuries (TBIs) are a leading cause of death and dis- ability. Sports-related TBIs are estimated to be more than several million per year. The pathophysiology of TBIs involves high levels of inflammation, oxidative stress, dysregulation of ion homeosta- sis, mitochondrial dysfunction, and apoptosis. There is also a reduc- tion in cerebral blood flow, leading to hypoxia and reduced