In VitroMolecular hydrogen suppresses Porphyromonas gingivalis lipopolysaccharide‑induced increases in interleukin‑1 alpha and interleukin‑6 secretion in human gingival cellsMHID-1605109PMID: 345336462022Molecular and Cellular BiochemistryYasukazu Saitoh, Nene Yonekura, Daigo Matsuoka, Akira MatsumotoPeriodontitis is defined as a multifactorial polymicrobial infection accompanied by inflammatory reactions. Porphyromonas gingivalis (Pg) is known as a major pathogen in the initiation and progression of periodontitis, and a major virulence factor is Pg lipopolysaccharide (LPS). Molecular hydrogen (H2) has been reported to act as a gaseous antioxidant, which suppresses periodontitis progression by
Animal StudyMolecular Hydrogen in Drinking Water Protects against Neurodegenerative Changes Induced by Traumatic Brain InjuryMHID-0185761PMID: 252512202014PLoS ONEKenji Dohi, Brian C. Kraemer, Michelle A. Erickson, Pamela J. McMillan, Andrej Kovac, Zuzana Flachbartova, et al.Traumatic brain injury (TBI) in its various forms has emerged as a major problem for modern society. Acute TBI can transform into a chronic condition and be a risk factor for neurodegenerative diseases such as Alzheimer’s and Parkinson’s diseases, probably through induction of oxidative stress and neuroinflammation. Here, we examined the ability of the antioxidant molecular hydrogen given in drink
