Animal StudyHighlighted
MHID-2924238PMID: 371112842023Pharmaceuticals
Murat Kayaba¸s, Levent ¸Sahin, Mustafa Makav, Duried Alwazeer, Levent Aras, Serdar Yi˘git, et al.
The anti-inflammatory and anti-apoptotic effects of molecular hydrogen, delivered as hydrogen-rich saline (HRS), on spinal cord injury was investigated. Four-month-old male Sprague Dawley rats (n = 24) were classified into four groups: (1) control—laminectomy only at T7-T10; (2) spinal injury—dura left intact, Tator and Rivlin clip compression model applied to the spinal cord for 1 min, no treatment
Animal Study
MHID-0385819PMID: 358952452023Journal of Neuroimmune Pharmacology
Wan‑Chao Yang, Ting‑ting Li, Qiang Wan, Xin Zhang, Li‑Ying Sun, Yu‑Rong Zhang, et al.
Diabetes is an independent risk factor for stroke and amplifies inflammation. Diabetic stroke is associated with a higher risk of death and worse neural function. The identification of effective anti-inflammatory molecules with translational advantages is particularly important to promote perioperative neurorestorative effects. Applying molecular hydrogen, we measured blood glucose levels before a
Clinical TrialHighlighted
MHID-6939973PMID: 373719752023Antioxidants
Bing Liang, Le Shi, Dongyue Du, Hua Li, Ning Yi, Yue Xi, et al.
Objective: Molecular hydrogen (H2) exhibits antioxidant, anti-inflammatory and anti-apoptotic effects, and has shown benefits in glucose and lipid metabolism in certain animal metabolic disorder models. However, the potential benefits of H2 treatment in individuals with impaired fasting glucose (IFG) has seldom been studied. This randomized controlled study (RCT) aims to investigate the effects of hy
Animal StudyIn VitroHighlighted
MHID-1279019PMID: 372155682023Theranostics
Geru Tao, Feng Liu, Zhaokui Jin, Boyan Liu, Hao Wang, Daosheng Li, et al.
Background: Chronic liver diseases (CLD) frequently derive from hepatic steatosis, inflammation and fibrosis, and become a leading inducement of cirrhosis and hepatocarcinoma. Molecular hydrogen (H2) is an emerging wide-spectrum anti-inflammatory molecule which is able to improve hepatic inflammation and metabolic dysfunction, and holds obvious advantages in biosafety over traditional anti-CLD dru
Clinical TrialHighlighted
MHID-1277179PMID: 373719712023Antioxidants
Md. Habibur Rahman, Johny Bajgai, Subham Sharma, Eun-Sook Jeong, Seong Hoon Goh, Yeon-Gyu Jang, et al.
Molecular hydrogen (H2) is a versatile therapeutic agent. H2 gas inhalation is reportedly safe and has a positive impact on a range of illnesses, including Alzheimer’s disease (AD). Herein, we investigated the effects of 4 weeks of H2 gas inhalation on community-dwelling adults of various ages. Fifty-four participants, including those who dropped out (5%), were screened and enrolled. The selected
Animal StudyHighlighted
MHID-6941053PMID: 378959072023Pharmaceuticals
Seyedeh Elnaz Nazari, Alex Tarnava, Nima Khalili-Tanha, Mahdieh Darroudi, Ghazaleh Khalili-Tanha, Amir Avan, et al.
Skeletal muscle atrophy is associated with poor quality of life and disability. Thus, finding a new strategy for the prevention and treatment of skeletal muscle atrophy is very crucial. This study aimed to investigate the therapeutic potential of hydrogen-rich water (HRW) on muscle atrophy in a unilateral hind limb immobilization model. Thirty-six male Balb/C mice were divided into control (without
In VitroHighlighted
MHID-35766222022Processes
Subham Sharma, Johny Bajgai, Jayson M. Antonio, Ailyn Fadriquela, Thuy Thi Trinh, Md. Habibur Rahman, et al.
Diabetes is coupled with hyperglycemia, a state in which elevated glucose levels trigger oxidative stress (OS) in various body functions. One of the organs most afflicted by diabetes is the kidney. Despite this, specific treatments to mitigate the harmful effects of hyperglycemia-induced OS in the kidney have not been extensively explored. This study evaluates the anti-hyperglycemic efficacy of magne
In VitroHighlighted
MHID-02613512022Processes
Subham Sharma, Kyu-Jae Lee, Johny Bajgai, Thuy Thi Trinh, Jayson M. Antonio, Md. Habibur Rahman, et al.
Diabetes, a chronic metabolic disorder, affects glucose consumption in the body and leads to severe kidney damage, known as diabetic nephropathy, where oxidative stress (OS) plays a vital role in disease pathogenesis. Electrolyzed weakly alkaline reduced water (EWARW) is known to have anti-oxidative functions in vitro due to its bioactive properties. However, there is an increasing need for adequa
Animal StudyHighlighted
MHID-1698660PMID: 354927052022Frontiers in Psychiatry
Noriyoshi Usui, Kazumasa Matsumoto-Miyai, Yoshihisa Koyama, Yuki Kobayashi, Yukiko Nakamura, Hikaru Kobayashi, et al.
Maternal immune activation (MIA) is triggered by infection or autoimmune predisposition during pregnancy, and cytokines produced by MIA are transmitted through the placenta to the fetal brain, implicating at the onset risks and vulnerability for developmental and psychiatric disorders, such as autism spectrum disorder (ASD) and schizophrenia. To address these kinds of problem in child health, we h
Clinical TrialHighlighted
MHID-50217702022European Journal of Inflammation
Aleksandra Milovancev, Jovana Avakumovic, Patrik Drid, Nikola Todorovic, Valdemar Stajer, Sergej M Ostojic
Molecular hydrogen (H2) has been recently put forward as a possible adjunct therapeutics in COVID-19 due to its anti-inflammatory and pulmo-protective effects.1,2 An open-label randomized trial in 44 patients with laboratory-confirmed COVID-19 from seven hospitals in China demonstrated that 3-day hydrogen inhalation resulted in significantly more patients with improved disease severity and reduced dy
Clinical TrialObservational StudyHighlighted
MHID-6130347PMID: 357749172022Health Psychology Research
Ana Belén Fernández-Serrano, Francisco José Moya-Faz, Cesar Augusto Giner Alegría, Juan Carlos Fernández Rodríguez, Jose Francisco Soriano Guilabert, Martín del Toro Mellado
Research suggests that inflammation is an important mediator in the pathophysiology of anxiety disorders. In addition, women are more likely to develop an anxiety and depression disorder, in comorbidity with a wide spectrum of diseases related to the immune system. In recent years, hydrogen-rich water has emerged as a promising therapeutic strategy to prevent and intervene in stress-related disord
Clinical TrialAnimal StudyIn VitroHighlighted
MHID-2649268PMID: 357349742022Journal of Cellular and Molecular Medicine
Geru Tao, Guangjie Zhang, Wei Chen, Chao Yang, Yazhuo Xue, Guohua Song, et al.
Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease
worldwide with increasing incidence consistent with obesity, type 2 diabetes and
cardiovascular diseases. No approved medication was currently available for NAFLD
treatment. Molecular hydrogen (H2), an anti-oxidative, anti-inflammatory biomedical
agent is proved to exhibit therapeutic and preventive effect in variou
Animal StudyHighlighted
MHID-9667503PMID: 349703492022Experimental and Therapeutic Medicine
Yun Hu, Xiaoyan Feng, Junhui Chen, Yan Wu, Liuyan Shen
Traumatic brain injury (TBI) has been recognized as a serious public health issue and a key contributor to disability and death, with a huge economic burden worldwide. Hydrogen, which is a slight and specific cytotoxic oxygen radical scav‑enger, has been demonstrated to ameliorate early brain injury (EBI) through reactive oxygen species (ROS), oxidative stress injury, apoptosis and necroptosis. Ne
Animal StudyIn VitroHighlighted
MHID-5758484PMID: 353001732022Oxidative Medicine and Cellular Longevity
Yujie Li, Chengcheng Shen, Xin Zhou, Jianghe Zhang, Xiaoyue Lai, Yiming Zhang
Wound healing is a complex dynamic process involving a large number of biological events. Excessive oxidative stress is a key factor delaying wound healing. Hydrogen is an antioxidant, anti-inflammatory, and antiapoptotic medical gas with safety, effectiveness, and penetrability. However, the effects of local treatment of hydrogen on wound healing and its potential mechanisms remain unclear. In this
In Vitro
MHID-1605109PMID: 345336462022Molecular and Cellular Biochemistry
Yasukazu Saitoh, Nene Yonekura, Daigo Matsuoka, Akira Matsumoto
Periodontitis is defined as a multifactorial polymicrobial infection accompanied by inflammatory reactions. Porphyromonas gingivalis (Pg) is known as a major pathogen in the initiation and progression of periodontitis, and a major virulence factor is Pg lipopolysaccharide (LPS). Molecular hydrogen (H2) has been reported to act as a gaseous antioxidant, which suppresses periodontitis progression by
Clinical TrialObservational StudyHighlighted
MHID-99610682021Journal of Education, Health and Sport
Yurii Rohovyi, Volf Tsitrin, Yula Bilooka, Ludmila Arkchipova, Vyacheslav Bilookiy
Aim. To find out a pathophysiological protective role of influence of molecular hydrogen on a functional condition of a proximal tubule of kidneys at an irritable bowel syndrome.
Materials and methods. 60 patients with irritable bowel syndrome were examined. Men - 18, women - 42 aged from 28 to 62 years. Of which: with irritable bowel syndrome with constipation were - 28 patients, irritable bowel
Animal StudyHighlighted
MHID-2919108PMID: 349481072021International Journal of Molecular Sciences
Eun-Sook Jeong, Johny Bajgai, In-Soo You, Md. Habibur Rahman, Ailyn Fadriquela, Subham Sharma, et al.
Oxidative stress (OS) is one of the causative factors in the pathogenesis of various neurode- generative diseases, including Alzheimer’s disease (AD) and cognitive dysfunction. In the present study, we investigated the effects of hydrogen (H2) gas inhalation in trimethyltin (TMT)-induced neurotoxicity and cognitive dysfunction in the C57BL/6 mice. First, mice were divided into the following groups
Animal Study
MHID-1210077PMID: 333568672021Canadian Journal of Physiology and Pharmacology
Jonatas E. Nogueira, Mateus R. Amorim, Ana P. Pinto, Alisson L. da Rocha, Adelino S. R. da Silva, Luiz G. S. Branco
Physical exercise-induced skeletal muscle damage may be characterized by increased oxidative stress, inflammation, and apoptosis which may be beneficial when exercise is regular, but it is rather harmful when exercise is exhaustive and performed acutely by unaccustomed individuals. Molecular hydrogen (H2) has emerged as a potent antioxidant, anti-inflammatory, and anti-apoptotic agent, but its act
Observational StudyHighlighted
MHID-5864798PMID: 347652122021Clinical Case Reports
Ram B. Singh, Ghazi Halabi, Ghizal Fatima, Richa H. Rai, Alexander T. Tarnava, Tyler W. LeBaron
Administration of molecular hydrogen dissolved in water to patient with COVID-19-like symptoms may improve oxygen levels and exercise capacity.
Observational StudyHighlighted
MHID-6285582PMID: 346451002021Journal of Integrative Neuroscience
Tyler W. LeBaron, Jason Kharman, Michael L. McCullough
Traumatic brain injuries (TBIs) are a leading cause of death and dis- ability. Sports-related TBIs are estimated to be more than several million per year. The pathophysiology of TBIs involves high levels of inflammation, oxidative stress, dysregulation of ion homeosta- sis, mitochondrial dysfunction, and apoptosis. There is also a reduc- tion in cerebral blood flow, leading to hypoxia and reduced
