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Hydrogen-Rich Saline Alleviates Kidney Fibrosis Following AKI and Retains Klotho Expression

MHID-3260346PMID: 288484322017Frontiers in Pharmacology

Jing Chen, Han Zhang, Jiachang Hu, Yulu Gu, Ziyan Shen, Linghan Xu, et al.

Purpose: Acute kidney injury (AKI) is a prominent risk factor for the development of chronic kidney disease (CKD). To date, the related mechanism and effective therapy have not been rigorously explored. The present study aims to investigate the reno- protection of hydrogen-rich saline (HRS) against ischemia/reperfusion (IR)-induced AKI. Methods: Adult male C57 mice were randomly allocated into th