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Animal Study

Molecular Hydrogen Attenuates Neuropathic Pain in Mice

MHID-1154767PMID: 249410012014PLoS ONE

Masanori Kawaguchi, Yasushi Satoh, Yukiko Otsubo, Tomiei Kazama

Neuropathic pain remains intractable and the development of new therapeutic strategies are urgently required. Accumulating evidence indicates that overproduction of oxidative stress is a key event in the pathogenesis of neuropathic pain. However, repeated intra-peritoneal or intrathecal injections of antioxidants are unsuitable for continuous use in therapy. Here we show a novel therapeutic method