In VitroHighlightedMolecular hydrogen inhibits lipopolysaccharide-triggered NLRP3 inflammasome activation in macrophages by targeting the mitochondrial reactive oxygen speciesMHID-1084413PMID: 264880872016Biochimica et Biophysica Acta - Molecular Cell ResearchJian-Dong Ren, Xiao-Bo Wu, Rui Jiang, Da-Peng Hao, Yi LiuThe NLRP3 inflammasome, an intracellular multi-protein complex controlling the maturation of cytokine interleukin-1β, plays an important role in lipopolysaccharide (LPS)-induced inflammatory cascades. Recently, the production of mitochondrial reactive oxygen species (mtROS) in macrophages stimulated with LPS has been suggested to act as a trigger during the process of NLRP3 inflammasome activation