Animal StudyHighlighted
MHID-8967574PMID: 416411602026Frontiers in Nutrition
Eika Mizuno, Tatsuhiro Sato, Kosuke Okada, Ikuru Miura, Junichi Shoda, Makoto Saito, et al.
Introduction: Hydrogen-rich water (HRW) has been reported to reduce oxidative stress, suppress exercise fatigue, and enhance recovery. However, the molecular mechanisms of its effects on exercise capacity, especially during the early stages of adaptation in physically inactive individuals, remain unclear.
Methods: Male 8-week-old C57BL/6 J mice were provided with purified water or HRW for 1, 2, 4,
Animal StudyIn VitroHighlighted
MHID-1663779PMID: 405801852026Medical Gas Research
Yinyin Zhang, Yajing Ying, Xianpeng Zu, Lingling Ding, Xuan Shi, Jing Wang, et al.
Exercise-induced fatigue limits athletic performance. Molecular hydrogen is an effective treatment for relieving fatigue, but the exact mechanism is not clear. In our study, a mouse model of fatigue was established to explore the molecular mechanism by which hydrogen-rich water reduces exercise-induced fatigue. The results showed that hydrogen-rich water improved the motor function of fatigue mice
Literature ReviewHighlighted
MHID-45792272025International Journal of Molecular Sciences
Dominika Zajac, Monika Jampolska, Piotr Wojciechowski
Molecular hydrogen is gaining increasing attention as an antioxidant, anti-
inflammatory, and antiapoptotic agent. Once considered an inert gas, it reveals current
therapeutic potential among others in inflammatory diseases, cancer, and sports medicine,
among others. The present review aims to provide a consistent summary of the findings
of the last twenty years on the use of molecular hydrogen in
Animal StudyIn VitroHighlighted
MHID-7283969PMID: 417999532025Materials Today Bio
Chunru Kong, Chao Si, Haofeng Liu, Yawen Wang, Jiakai Qiao, Xiaoduo Tang, et al.
The repair of infected bone defects (IBDs) presents a significant clinical challenge due to recurrent infections and
inflammation. Characterized by reactive oxygen species (ROS) bursts and mitochondrial dysfunction, IBDs
generates to a vicious oxidation-inflammation cycle that impairs bone remodeling. To address this, we developed
a double-network hydrogel scaffold composed of phenylboronic acid-m
Animal StudyHighlighted
MHID-3793036PMID: 394330132024International Immunopharmacology
Shuaijie Pei, Lina Zheng, Zhigang Tian, Shuqi Meng, Zhiwei Wang, Yan Fan, et al.
Sepsis is a major cause of mortality among critical patients. Acute kidney injury (AKI) is the common complication in patients with sepsis, characterized by rapid deterioration of renal function. The purpose of this study is to assess the impact of inhaling high concentration hydrogen on septic mice with AKI and to examine the involvement of mitochondria in this process. High concentration hydroge
Animal StudyHighlighted
MHID-8765977PMID: 390619242024Antioxidants
Ignacio Martínez-Martel, Xue Bai, Rebecca Kordikowski, Christie R. A. Leite-Panissi, Olga Pol
Chemotherapy-provoked peripheral neuropathy and its associated affective disorders are important adverse effects in cancer patients, and its treatment is not completely resolved. A recent study reveals a positive interaction between molecular hydrogen (H2) and a heme oxygenase (HO-1) enzyme inducer, cobalt protoporphyrin IX (CoPP), in the inhibition of neuropathic pain provoked by nerve injury. Ne
In VitroHighlighted
MHID-2493537PMID: 390620202024Biomedicines
Sing-Hua Tsou, Sheng-Chieh Lin, Wei-Jen Chen, Hui-Chih Hung, Chun-Cheng Liao, Edy Kornelius, et al.
Metabolic dysfunction-associated steatotic liver disease (MASLD) is characterized by exces- sive fat accumulation in the liver. Intracellular oxidative stress induced by lipid accumulation leads to various hepatocellular injuries including fibrosis. However, no effective method for mitigating MASLD without substantial side effects currently exists. Molecular hydrogen (H2) has garnered attention du
Clinical TrialIn VitroObservational StudyHighlighted
MHID-30414712023Processes
Richard J. Bloomer, Yufeng Zhang, Joshua Y. Shirazi, Chidimma Okegbe, Jacquelyn Pence, Keith Martin, et al.
Alpha Hope is a dietary supplement containing pyrroloquinoline quinone and elemental magnesium, which produces molecular hydrogen (H2 gas) when dissolved in water. We determined the impact of Alpha Hope on Nrf-2, peroxisome proliferator-activated receptor-gamma coactivator (PGC-1α), and citrate synthase (CS) activity in C2C12 myoblasts. Alpha Hope was titrated to three concentrations of pyrroloqui
Animal StudyChemical/Physicochemical StudyHighlighted
MHID-2226442PMID: 374635172023Canadian Journal of Physiology and Pharmacology
Barbora Kalocayova, Branislav Kura, Jana Vlkovicova, Denisa Snurikova, Norbert Vrbjar, Karel Frimmel, et al.
Cardiac surgery-associated acute kidney injury (CS-AKI) is a common postoperative complication, mostly due to increasing oxidative stress. Recently, molecular hydrogen (H2 gas), has also been applied to cardiac surgery due to its ability to reduce oxidative stress. We evaluated the potential effect of H2 application on the kidney in an in vivo model of simulated heart transplantation. Pigs underwe
Animal StudyHighlighted
MHID-1698660PMID: 354927052022Frontiers in Psychiatry
Noriyoshi Usui, Kazumasa Matsumoto-Miyai, Yoshihisa Koyama, Yuki Kobayashi, Yukiko Nakamura, Hikaru Kobayashi, et al.
Maternal immune activation (MIA) is triggered by infection or autoimmune predisposition during pregnancy, and cytokines produced by MIA are transmitted through the placenta to the fetal brain, implicating at the onset risks and vulnerability for developmental and psychiatric disorders, such as autism spectrum disorder (ASD) and schizophrenia. To address these kinds of problem in child health, we h
Animal StudyHighlighted
MHID-9667503PMID: 349703492022Experimental and Therapeutic Medicine
Yun Hu, Xiaoyan Feng, Junhui Chen, Yan Wu, Liuyan Shen
Traumatic brain injury (TBI) has been recognized as a serious public health issue and a key contributor to disability and death, with a huge economic burden worldwide. Hydrogen, which is a slight and specific cytotoxic oxygen radical scav‑enger, has been demonstrated to ameliorate early brain injury (EBI) through reactive oxygen species (ROS), oxidative stress injury, apoptosis and necroptosis. Ne
Animal StudyIn VitroHighlighted
MHID-5758484PMID: 353001732022Oxidative Medicine and Cellular Longevity
Yujie Li, Chengcheng Shen, Xin Zhou, Jianghe Zhang, Xiaoyue Lai, Yiming Zhang
Wound healing is a complex dynamic process involving a large number of biological events. Excessive oxidative stress is a key factor delaying wound healing. Hydrogen is an antioxidant, anti-inflammatory, and antiapoptotic medical gas with safety, effectiveness, and penetrability. However, the effects of local treatment of hydrogen on wound healing and its potential mechanisms remain unclear. In this
Observational StudyHighlighted
MHID-6285582PMID: 346451002021Journal of Integrative Neuroscience
Tyler W. LeBaron, Jason Kharman, Michael L. McCullough
Traumatic brain injuries (TBIs) are a leading cause of death and dis- ability. Sports-related TBIs are estimated to be more than several million per year. The pathophysiology of TBIs involves high levels of inflammation, oxidative stress, dysregulation of ion homeosta- sis, mitochondrial dysfunction, and apoptosis. There is also a reduc- tion in cerebral blood flow, leading to hypoxia and reduced
Animal StudyIn VitroHighlighted
MHID-2423362PMID: 334391022021American Journal of Physiology - Gastrointestinal and Liver Physiology
Shao-Wei Li, Terumi Takahara, Weitao Que, Masayuki Fujino, Wen-Zhi Guo, Shin-ichi Hirano, et al.
Nonalcoholic steatohepatitis (NASH) could progress to hepatic fibrosis in the absence of effective control. The purpose of our experiment was to investigate the protective effect of drinking water with a high concentration of hydrogen, namely, hydrogen-rich water (HRW), on mice with nonalcoholic fatty liver disease to elucidate the mechanism underlying the therapeutic action of molecular hydrogen.
In VitroHighlighted
MHID-35801392020Molecular & Cellular Toxicology
Rahima Begum, Cheol‑Su Kim, Ailyn Fadriquela, Johny Bajgai, Xingyu Jing, Dong‑Heui Kim, et al.
Background: Oxidative stress is involved in the development of many inflammatory, metabolic and aging diseases.
Objective: In this study we investigated, the protective effects of H2 on RAW 264.7 macrophage cell against LPS-and H2O2-induced oxidative stress by the inhibition of MAPK pathway and also activate the Nrf2 pathway.
Results: Our results showed H2 increased the macrophage cell prolifera
In VitroHighlighted
MHID-7135279PMID: 345586532020Journal of Investigative Dermatology
Wei Fang, Luyan Tang, Guizhen Wang, Jinran Lin, Wanqing Liao, Weihua Pan, et al.
Oxidative stress is proven to be critical for the initiation and progression of vitiligo. Molecular hydrogen (H2) possesses potent antioxidant activity and has been shown to protect against various oxidative stresserelated diseases. In this study, we first investigated the effects and mechanisms of H2 in human melanocytes damaged by hydrogen peroxide. We initially found that H2 reduced intracellula
Animal StudyHighlighted
MHID-9762050PMID: 266686282015Experimental and Therapeutic Medicine
Xiaoyin Meng, Hongguang Chen, Guolin Wang, Yonghao Yu, Keliang Xie
Hydrogen has been reported to exert a therapeutic effect in several diseases due to its antioxidative, anti‑inflammatory and anti‑apoptotic properties. The aim of the present study was to investigate whether hydrogen‑rich saline treatment could attenuate ovarian damage induced by cisplatin. A total of 240 adult, virgin, female Sprague Dawley rats, weighing 180‑220 g, were randomly divided into fou
