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Animal StudyHighlighted

Effect of Hydrogen on Pentylenetetrazole‑Induced Seizures in Ovariectomized Rats

MHID-15287492025Bratislava Medical Journal

Miktat Kaya, Mustafa Makav, Ebru Karadağ Sarı, Şükran Yediel Aras, Mushap Kuru, Abdussamed Vural, et al.

The aim of the study was to investigate the therapeutic efficacy of hydrogen-rich water in pentylenetetrazol-induced epilepsy. A total of 30 female rats, 6 animals in each group, were used in the study. All groups except the control group were ovariec- tomized. Hydrogen-rich water Group (HRW) and Epilepsy + HRW Group (E + HRW) were administered intraperitoneally for 14 days. On the 14th day of the

Animal StudyHighlighted

Inhalation of Hydrogen Attenuates Progression of Chronic Heart Failure via Suppression of Oxidative Stress and P53 Related to Apoptosis Pathway in Rats

MHID-0582328PMID: 301085862018Frontiers in Physiology

Jing Chi, Zizhuo Li, Xiaojian Hong

Background: Continuous damage from oxidative stress and apoptosis are the important mechanisms that facilitate chronic heart failure (CHF). Molecular hydrogen (H2) has potentiality in the aspects of anti-oxidation. The objectives of this study were to investigate the possible mechanism of H2 inhalation in delaying the progress of CHF. Methods and Results: A total of 60 Sprague-Dawley (SD) rats wer