Animal StudyHighlightedMolecular hydrogen protects against sepsis-induced cardiomyopathy through improving Golgi stress-mediated autophagy, inflammation and apoptosisMHID-5014710PMID: 407174652025British Journal of PharmacologyShuqi Meng, Jianfeng Liu, Yanhua Luo, Yan Fan, Zhiwei Wang, Yu Song, et al.Background and Purpose: Sepsis-induced cardiomyopathy (SIC) is the primary cause of mortality among people with sepsis. Hydrogen (H2) has a cardioprotective effect in SIC; however, its specific mechanism remains unclear. We thus explored whether 2% H2 treatment mitigates SIC through inhibiting Golgi stress and investigated the specific molecular pathways underlying this protective effect. Experime
Animal StudyMolecular hydrogen attenuates sepsis-induced cardiomyopathy in mice by promoting autophagyMHID-5679511PMID: 383958002024BMC AnesthesiologyYan Cui, Yingning Li, Shuqi Meng, Yu Song, Keliang XieBackground: Approximately 40 to 60% of patients with sepsis develop sepsis-induced cardiomyopathy (SIC), which is associated with a substantial increase in mortality. We have found that molecular hydrogen (H2) inhalation improved the survival rate and cardiac injury in septic mice. However, the mechanism remains unclear. This study aimed to explore the regulatory mechanism by which hydrogen modula
In VitroHighlightedHydrogen-Rich Water (HRW) Reduces Fatty Acid-Induced Lipid Accumulation and Oxidative Stress Damage through Activating AMP-Activated Protein Kinase in HepG2 CellsMHID-2493537PMID: 390620202024BiomedicinesSing-Hua Tsou, Sheng-Chieh Lin, Wei-Jen Chen, Hui-Chih Hung, Chun-Cheng Liao, Edy Kornelius, et al.Metabolic dysfunction-associated steatotic liver disease (MASLD) is characterized by exces- sive fat accumulation in the liver. Intracellular oxidative stress induced by lipid accumulation leads to various hepatocellular injuries including fibrosis. However, no effective method for mitigating MASLD without substantial side effects currently exists. Molecular hydrogen (H2) has garnered attention du
