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Animal StudyIn VitroHighlighted

Molecular Hydrogen Suppresses Reactive Astrogliosis Related to Oxidative Injury during Spinal Cord Injury in Rats

MHID-0826156PMID: 246851142014CNS Neuroscience & Therapeutics

Fang-Ting Liu, Sheng-Ming Xu, Zheng-Hua Xiang, Xiang-Nan Li, Jian Li, Hong-Bin Yuan, et al.

Aims: Spinal cord injury (SCI) can induce excessive astrocyte activation. Hydrogen has been deemed as a novel antioxidant. We investigated whether molecular hydrogen could act as an antiastrogliosis agent during SCI and oxidative injury in experimental rats and cultured astrocytes. Methods: Hydrogen-rich saline (HS, 8 mL/kg, i.p.) was injected every 12 h after SCI in rats. The expression of STAT3,