Animal StudyEx VivoHighlightedDegradation products of magnesium implant synergistically enhance bone regeneration: Unraveling the roles of hydrogen gas and alkaline environmentMHID-4421003PMID: 398164752025Bioactive MaterialsYuanming An, Haozhi Zhang, Shi’an Zhang, Yuantao Zhang, Lizhen Zheng, Xin Chen, et al.Biodegradable magnesium (Mg) implant generally provides temporary fracture fixation and facilitates bone regeneration. However, the exact effects of generated Mg ions (Mg2+), hydrogen gas (H2), and hydroxide ions (OH-) by Mg degradation on enhancing fracture healing are not fully understood. Here we investigate the in vivo degradation of Mg intramedullary nail (Mg-IMN), revealing the generation of
Animal StudyIn VitroEx VivoHighlightedHydrogen activates ACOD1-itaconate pathway to ameliorate steroid-associated osteonecrosisMHID-9370665PMID: 404119852025BiomaterialsYuanming An, Lizhen Zheng, Shi’an Zhang, Haozhi Zhang, Yuantao Zhang, Hongwei Shao, et al.Steroid-associated osteonecrosis (SAON) remains a challenging clinical condition as there are few effective preventive measures. This study investigates the effects of hydrogen (H2) administrated via saturated hydrogen-rich water (HRW) in mice received high dose of glucocorticoids (for inducing SAON model). Here we find that HRW treatment significantly reduces osteocyte apoptosis, improves deterio
