Observational Study
MHID-31585802025Sport Sciences for Health
Nikola Todorovic, Jovan Kuzmanovic, Dejan Javorac, Sergej M Ostojic
Purpose Exercise induces transient physiological disruptions, including immune suppression and gastrointestinal (GI) disturbance. Molecular hydrogen (H₂), an endogenously produced gas with antioxidant and anti-inflammatory properties, may play a protective role in this context. While the therapeutic potential of exogenous H₂ has been widely explored, little is known about endogenous hydrogen respo
HypothesisOpinion PieceHighlighted
MHID-6155704PMID: 402510252025Medical Gas Research
Nikola Todorovic, Jovan Kuzmanovic, Dejan Javorac, Sergej M Ostojic
The increasing prevalence of obesity and non-communicable diseases has become a major global health concern, contributing to significant morbidity and mortality rates. These conditions not only burden healthcare systems but also affect the individual’s quality of life worldwide. As these challenges continue to grow, there is a pressing need to explore treatment options that are effective, affordab
Clinical Trial
MHID-14786562024Current Developments in Nutrition
Sonja Baltic, Nikola Todorovic, Marijana Ranisavljev, Dragana Zanini, David Nedeljkovic, Darinka Korovljev, et al.
Objectives: Molecular hydrogen (H2) and pyrroloquinoline quinone (PQQ) have been suggested to activate metabolic pathways associated with cognition. No human studies have assessed the efficacy of this nutritional combination in the clinical context of mild cognitive impairment (MCI). The primary objective of this randomized placebo-controlled trial was to evaluate the effects of a six-week suppleme
Clinical TrialAnimal Study
MHID-3281965PMID: 391245752024Journal of Clinical Medicine
Yoann Gaboreau, Aleksandra Milovanˇcev, Carole Rolland, Claire Eychenne, Jean-Pierre Alcaraz, Cordelia Ihl, et al.
Background. Due to its antioxidant, anti-inflammatory, anti-apoptosis, and anti-fatigue properties, molecular hydrogen (H2) is potentially a novel therapeutic nutrient for patients with coronavirus acute disease 2019 (COVID-19). We determined the efficacy and safety profile of hydrogen-rich water (HRW) to reduce the risk of COVID-19 progression.
Methods: We also conducted a phase 3, triple-blind,
Clinical TrialHighlighted
MHID-7984305PMID: 389082962024The Journal of Nutrition, Health and Aging
Sonja Baltic, David Nedeljkovic, Nikola Todorovic, Marijana Ranisavljev, Darinka Korovljev, Jelena Cvejic, et al.
Objectives: To assess the impact of medium-term supplementation with dihydrogen and pyrroloquinoline quinone (PQQ) on mitochondrial biomarkers, brain metabolism, and cognition in elderly individuals diagnosed with mild cognitive impairment.
Design: A parallel-group, randomized, placebo-controlled, double-blind experimental design, maintaining a 1:1 allocation ratio between the experimental group (
Clinical TrialHighlighted
MHID-5537085PMID: 375607462023Archives of Medical Science
Darinka Korovljev, Jelena Ostojic, Nikola Todorovic, Sergej M Ostojic
Introduction: We evaluated whether 12-week intake of molecular hydrogen (H2) in 5 overweight adults (3 women; age: 50.2 ±11.9 years, body mass index: 29.4 ±2.1 kg/m2) affects brain levels of the glutamate-glutamine-GABA cycle, critical amino acid neurotransmitters in the mechanism of neuronal activation during appetite regulation.
Methods: A 1.5-T single-voxel proton magnetic resonance spectrosco
Systematic ReviewHighlighted
MHID-32722772023Pharmaceuticals
Nikola Todorovic, Julen Fernández-Landa, Asier Santibañez, Branislav Kura, Valdemar Stajer, Darinka Korovljev, et al.
Over the last two decades, a plethora of disease models and human studies have confirmed the beneficial effects of molecular hydrogen (H2), a simple biotherapeutic gas. Recent small-scale studies evaluating the effects of hydrogen-rich water (HRW) on various metabolic conditions pointed to advantageous effects of HRW in regulating blood lipid profiles. However, to the best of the authors’ knowledge,
Clinical TrialHighlighted
MHID-9342144PMID: 377341172023Nutrition
Darinka Korovljev Ph.D., Nikola Todorovic M.Sc., Marijana Ranisavljev M.Sc., Bogdan Andjelic M.Sc., Nebojsa Kladar M.D., Ph.D., Valdemar Stajer Ph.D., et al.
The intricate relationship between the gut microbiota, its metabolites, and human health has garnered significant attention in recent years because of its potential role in the development of many diseases [1]. Among the various metabolites produced by the microbiota, a group of organic acids, known as short-chain fatty acids (SCFAs), has emerged as key regulators of host energy metabolism. These
Literature ReviewHypothesisHighlighted
MHID-3205850PMID: 359678412022Frontiers in Cellular and Infection Microbiology
Sergej M Ostojic
The molecular footprints of COVID-19 occur everywhere, even reaching the family of biologically active gases and gasotransmitters. Besides nitric oxide and hydrogen sulfide, COVID-19 might also alter the homeostasis of dihydrogen (H2), another gaseous bioactive molecule produced endogenously by the human gut bacteria. Many studies have shown various alterations of the gut microbiota in patients wit
Clinical TrialHighlighted
MHID-50217702022European Journal of Inflammation
Aleksandra Milovancev, Jovana Avakumovic, Patrik Drid, Nikola Todorovic, Valdemar Stajer, Sergej M Ostojic
Molecular hydrogen (H2) has been recently put forward as a possible adjunct therapeutics in COVID-19 due to its anti-inflammatory and pulmo-protective effects.1,2 An open-label randomized trial in 44 patients with laboratory-confirmed COVID-19 from seven hospitals in China demonstrated that 3-day hydrogen inhalation resulted in significantly more patients with improved disease severity and reduced dy
Clinical TrialHighlighted
MHID-9740359PMID: 345320232021Food Science & Nutrition
Nikola Todorovic, Dragana Zanini, Valdemar Stajer, Darinka Korovljev, Jelena Ostojic, Sergej M Ostojic
The main aim of this randomized-controlled cross-over interventional trial was to assess the acute effects of taking a single dose of hydrogen-rich water (HRW), and compare it with caffeine, HRW plus caffeine, and control water, for alertness, brain metabolism, brain and oxygen saturation, and self-reported adverse events in healthy men and women who were habitual coffee drinkers and were sleep-de
HypothesisOpinion Piece
MHID-9436520PMID: 329827932020Frontiers in Physiology
Sergej M Ostojic
Barton et al. (2018) have recently evaluated the differences in fecal microbiota between professional rugby players and healthy age-matched sedentary controls. The authors reported a rather preferential intestinal microbiome profile in physically active individuals, characterized by the greater microbial diversity and functional/metabolic activity, as evaluated by whole metagenome shotgun sequencing
Opinion Piece
MHID-94117542020Therapeutic Advances in Respiratory Disease
Sergej M Ostojic
Recent public reports by China’s National Health Commission and the Chinese Center for Disease Control and Prevention have recommended effective oxygen therapy measures as an element of general treatment in patients with novel coronavirus pneumonia (COVID-19).1,2 Both documents disclosed a rather exotic ratio of hydrogen and oxygen (66.6% H2 to 33.3% O2) as the composition of the gas mixture for i
Human StudyHighlighted
MHID-3687397PMID: 323992092020F1000Research
Dejan Javorac, Valdemar Stajer, Sergej Ostojic
The traditional treatment of soft tissue injuries consists of the Background: RICE protocol – rest, ice, compression, and elevation, followed for up to 72 hours after a trauma. Although designed as an immediate therapy to reduce inflammation that occurs after an acute injury, the RICE protcol might not be the best way to promote healing due to limiting blood flow. Molecular hydrogen (H ) has recen
HypothesisHighlighted
MHID-3994699PMID: 324455282020Alimentary Pharmacology & Therapeutics
Sergej M Ostojic
EDITORS, I have read with great interest the systematic review with meta- analysis written by Ianiro and co-workers,1 in which the authors have evaluated the efficacy of faecal microbiota transplantation (FMT, or bacteriotherapy) for the treatment of irritable bowel syndrome (IBS). Although only a handful of studies were eligible to be included in this meticulous analysis, the authors implied that
Clinical TrialHighlighted
MHID-5701846PMID: 322737402020Diabetes, Metabolic Syndrome and Obesity
Tyler W. LeBaron, Ram B. Singh, Ghizal Fatima, Kumar Kartikey, Jagdish P Sharma, Sergej M Ostojic, et al.
Purpose: Metabolic syndrome is associated with several medical risk factors including dyslipidemia, hyperglycemia, and obesity, which has become a worldwide pandemic. The sequelae of this condition increase the risk of cardiovascular and neurological disease and increased mortality. Its pathophysiology is associated with redox dysregulation, excessive inflammation, and perturbation of cellular hom
Clinical TrialHighlighted
MHID-0587967PMID: 319380042019Biology of Sport
Dejan Javorac, Valdemar Stajer, Laszlo Ratgeber, Jozsef Betlehem, Sergej Ostojic
In this randomized, double-blind, placebo-controlled, crossover pilot trial, we evaluated the effects of 7-day H2 inhalation on exercise performance outcomes and serum hormonal and inflammation profiles in a cohort of young men and women. All participants (age 22.9 ± 1.5 years; body mass index 23.4 ± 2.5 kg m-2; 10 women and 10 men) were allocated to receive either gaseous hydrogen (4%) or placebo
Clinical TrialHighlighted
MHID-9688108PMID: 309827482019Clinics and Research in Hepatology and Gastroenterology
Darinka Korovljev, Valdemar Stajer, Jelena Ostojic, Tyler W. LeBaron, Sergej M Ostojic
Background and aims: While non-alcoholic fatty liver disease (NAFLD) is rapidly becoming the most common liver disease worldwide, its treatment remains elusive. Since metabolic impairment plays a major role in NAFLD pathogenesis, any pharmaceuticals, such as molecular hydrogen (H2), that advance lipid and glucose metabolism could be appropriate to tackle this complex condition. The aim of this stu
Observational StudyHighlighted
MHID-9389875PMID: 325959372019F1000Research
Dejan Javorac, Valdemar Stajer, Sergej M Ostojic
Sport-related mild traumatic brain injury (TBI) is a serious
Background:
trauma that could impair brain function of an injured athlete. Treatment
solutions for mild TBI typically concentrate on complete rest, while
non-traditional therapeutic options remain largely ineffective. Molecular
hydrogen (H ) is an innovative neuroprotective agent that can easily reach
the brain, yet no data are available
Clinical Trial
MHID-9868845PMID: 285605192018Irish Journal of Medical Science
D. Korovljev, T. Trivic, P. Drid, S. M. Ostojic
Background: Molecular hydrogen (H2) effectively treats obesity-related disorders in animal models, yet no studies have investigated the effectiveness and safety of H2 for improving biomarkers of obesity in humans.
Aim: In this double blind, placebo-controlled, crossover pilot trial, we evaluated the effects of H2 intervention on body composition, hormonal status, and mitochondrial function in ten
