In VitroHighlighted
MHID-0389345PMID: 415753722026Biochemical Journal
Sabrina Dezzani, Abdulrahman Alogaidi, Anca Pordea, Simone Morra
The production of biofuels by bacterial fermentation receives sustained attention due to the need to develop novel circular and sustainable technologies. Clostridium beijerinckii produces both hydrogen (H2) and carbon-based biofuels acetone, butanol and ethanol (ABE solvents). H2 metabolism in C. beijerinckii is complex and mostly unexplored. Seven hydrogenase genes are contained in the genome, bu
In SilicoHypothesisHighlighted
MHID-3775261PMID: 398291632025Medical Gas Research
Grace Russell
Hydrogen (H2), the simplest and most ubiquitous molecule in the universe, has garnered significant scientific interest over the past two decades because of its potential as an effective antioxidant and anti-inflammatory agent. Traditionally considered inert, H2 is now being re-evaluated for its unique bioactive properties. H2 selectively neutralizes reactive oxygen and nitrogen species, mitigating
In SilicoHighlighted
MHID-17877222024Microbes and Immunity
Grace Russell
Hydrogenase enzymes catalyze the reversible oxidation/reduction of hydrogen (H2) and play a crucial role in microbial energy metabolism, with significant implications for human immunity. H2, produced by gut microbes during fermentation or administered exogenously, is vital in modulating oxidative stress and inflammation. In the gastrointestinal tract, microbial H2 production can reach up to 13 L/d
Literature ReviewHighlighted
MHID-6653093PMID: 258736622024Journal of Plant Physiology and Metabolism
John T. Hancock
Gaseous hydrogen (H2) has emerged as a molecule that has a significant influence on the growth and development of plants, particularly if they are under stress. Often research has shown the ameliorating effects of H2 during drought, in the presence of heavy metals or salt, or during UV light irradiation. Postharvest, H2 has been shown to increase the quality of fruits and vegetables during storage
Literature ReviewHighlighted
MHID-86080102023Oxygen
John T. Hancock, Tyler W. LeBaron
In 2007 a paper in Nature Medicine sparked a new wave of interest in the use of molecular hydrogen (H2) for medical treatments. Since then there has been a flurry of papers looking at a range of medical aspects, from neurodegenerative disease to sports injuries. Several methods of application have been developed, including breathing the gas, or making a hydrogen-rich solution that can be ingested,
Literature Review
MHID-40908422023Oxygen
Tyler W. LeBaron, Kinji Ohno, John T. Hancock
Over 2000 publications including more than 100 human studies seem to indicate that humans have only recently benefited from or known about the medical effects of H2 within the past 15 years. However, we have unknowingly benefited from H2 since the dawn of time, from H2-producing bacteria to the use of naturally occurring hydrogen-rich waters. Moreover, the first writings on the therapeutic effects of
Literature Review
MHID-61283312023SciBase Clinical and Medical Case Reports
Grace Russell, Alexander Nenov
Human reproductive health is an integral part of personal well-being that can markedly impact upon individuals, couples,
families and the wider society. It is estimated that infertility affects 13 to 15% of the world’s population and with parents often
deciding to delay planning for pregnancy until later in life, age-related concerns about the viability of female oocytes, in partic
ular, are at th
In VitroHighlighted
MHID-57291662023Hydrogen
Grace Russell, Adam D. Thomas, Alexander Nenov, Georgia Mannings, John T. Hancock
Cancer is a leading cause of mortality worldwide. B-cells are a keystone of the adaptive immune response and are essential for the presentation of tumor-associated antigens to various types of T-cells. Approximately 1.5% of global cancer cases, including breast and gastric carcinomas and both Hodgkin’s and non-Hodgkin’s lymphomas, are linked with prior Epstein–Barr Virus (EBV) infection. Such prop
Hypothesis
MHID-81905412022Oxygen
John T. Hancock, Grace Russell, Tim J. Craig, Jennifer May, H. Ruth Morse, Jonathan S. Stamler
Hydrogen gas (molecular hydrogen, H2) has significant effects in a range of organisms, from plants to humans. Many inert gases have been reported to have similar effects, and such responses may be most pronounced when cells are stressed. Xenon (Xe), for example, is a well-known anesthetic. The direct targets of these gases, in most cases, remain elusive. Myoglobin and hemoglobin are known for their
Literature ReviewHypothesis
MHID-74012472022GSC Biological and Pharmaceutical Sciences
Grace Russell, Alexander Nenov
Women account for half of the global population, yet, when applying of the principles of legislation to women's health
and gender-based research there is a void pertaining to women-specific healthcare as they age. Hydrogen therapies
such as oxy-hydrogen (HHO, H2/O2) inhalation act as a novel, non-toxic, antioxidant and anti-inflammatory compounds,
with clinical and empirical research confidently s
Literature ReviewHighlighted
MHID-8010762PMID: 348346332021Plants
John T. Hancock, Tyler W. LeBaron, Jennifer May, Adam Thomas, Grace Russell
Despite being trialed in other regions of the world, the use of molecular hydrogen (H2) for enhanced plant growth and the postharvest storage of crops has yet to be widely accepted in the UK. The evidence that the treatment of plants and plant products with H2 alleviates plant stress and slows crop senescence continues to grow. Many of these effects appear to be mediated by the alteration of the a
Literature Review
MHID-48068842021Hydrogen
Grace Russell, Alexander Nenov, Hesham Kisher, John T. Hancock
Since the late 18th century, molecular hydrogen (H2) has been shown to be well tolerated, firstly in animals, and then in humans. However, although research into the beneficial effects of molecular hydrogen in both plant and mammalian physiology is gaining momentum, the idea of utilising this electrochemically neutral and non-polar diatomic compound for the benefit of health has yet to be widely acce
