Clinical TrialHighlighted
MHID-21966452019Canadian Journal of Physiology and Pharmacology
Toshio Mikami, Kohei Tano, Hosung Lee, Hyowon Lee, Jonghyuk Park, Fumiaki Ohta, et al.
Acute physical exercise increases reactive oxygen species in skeletal muscle, leading to tissue damage and fatigue. Molecular hydrogen (H2) acts as a therapeutic antioxidant directly or indirectly by inducing anti-oxidative enzymes. Here, we examined the effects of drinking H2 water (H2-infused water) on psychometric fatigue and endurance capacity in a randomized, double-blind, placebo-controlled
Clinical TrialHighlighted
MHID-4871667PMID: 309188322019Journal of Lifestyle Medicine
Tyler W. LeBaron, Abigail J. Larson, Shigeo Ohta, Toshio Mikami, Jordon Barlow, Josh Bulloch, et al.
Background: Clinical studies have reported hydrogen-rich water (HRW) to have therapeutic and ergogenic effects. The aim of this study was to determine the effect of acute supplementation with HRW on exercise performance as measured by VO2, respiratory exchange ratio (RER), heart rate (HR), and respiratory rate (RR).
Methods: Baseline levels of all exercise indices were determined in nineteen (4 f
Clinical TrialHighlighted
MHID-9688108PMID: 309827482019Clinics and Research in Hepatology and Gastroenterology
Darinka Korovljev, Valdemar Stajer, Jelena Ostojic, Tyler W. LeBaron, Sergej M Ostojic
Background and aims: While non-alcoholic fatty liver disease (NAFLD) is rapidly becoming the most common liver disease worldwide, its treatment remains elusive. Since metabolic impairment plays a major role in NAFLD pathogenesis, any pharmaceuticals, such as molecular hydrogen (H2), that advance lipid and glucose metabolism could be appropriate to tackle this complex condition. The aim of this stu
Animal StudyHighlighted
MHID-8554516PMID: 310619202019JACC: Basic to Translational Science
Alexis R. Cole, BS, Dorothy A. Perry, MBCHB, Ali Raza, MD, Arthur P. Nedder, DVM, Elizabeth Pollack, DVM CANDIDATE, William L. Regan, CCP, LP, et al.
This study used a swine model of mildly hypothermic prolonged circulatory arrest and found that the addition of 2.4% inhaled hydrogen gas to inspiratory gases during and after the ischemic insult significantly decreased neurologic and renal injury compared with controls. With proper precautions, inhalational hydrogen may be administered safely through conventional ventilators and may represent a co
Animal StudyHighlighted
MHID-7662943PMID: 308305292019Molecular and Cellular Biochemistry
Branislav Kura, Barbora Kalocayova, Tyler W. LeBaron, Karel Frimmel, Jozef Buday, Juraj Surovy, et al.
microRNAs (miRNAs) constitute a large class of post-transcriptional regulators of gene expression. It has been estimated that miRNAs regulate up to 30% of the protein-coding genes in humans. They are implicated in many physiological and pathological processes, including those involved in radiation-induced heart damage. Biomedical studies indicate that molecular hydrogen has potential as a radiopro
In VitroIn SilicoHighlighted
MHID-67149392018PLoS ONE
Anzu Suzuki, Mikako Ito, Tomonori Hamaguchi, Hiroshi Mori, Yuka Takeda, Ryuko Baba, et al.
Oral administration of hydrogen water ameliorates Parkinson’s disease (PD) in rats, mice, and humans. We previously reported that the number of putative hydrogen-producing bacte- ria in intestinal microbiota is low in PD compared to controls. We also reported that the amount of hydrogen produced by ingestion of lactulose is low in PD patients. The decreased hydrogen production by intestinal microb
Animal StudyIn VitroHighlighted
MHID-18249022018Translational Cancer Research
Lei Shang, Fei Xie, Jiala Li, Yating Zhang, Mengyu Liu, Pengxiang Zhao, et al.
Background: To investigate the potential effects of molecular hydrogen on ovarian cancer.
Methods: The in vivo study was performed using Hs38.T xenografted BALB/c nude mice. The mean tumor volume was monitored during 6 weeks of hydrogen inhalation. Immunohistochemistry (IHC) staining was performed to determine the Ki67 and CD34 expression. The in vitro effects of molecular hydrogen on proliferati
Clinical Trial
MHID-0476956PMID: 307136662018Medical Gas Research
Masaaki Hirayama, Mikako Ito, Tomomi Minato, Asako Yoritaka, Tyler W. LeBaron, Kinji Ohno
Hyposmia is one of the earliest and the most common symptoms in Parkinson’s disease (PD). The benefits of hydrogen water on motor deficits have been reported in animal PD models and PD patients, but the effects of hydrogen gas on PD patients have not been studied. We evaluated the effect of inhalation of hydrogen gas on olfactory function, non-motor symptoms, activities of daily living, and urinar
Animal StudyHighlighted
MHID-7672684PMID: 301277282018Frontiers in Behavioral Neuroscience
Qingjun Guo, Xi Yin, Meng Qiao, Yujiao Jia, Dandan Chen, Juan Shao, et al.
Due to its anti-inflammatory and anti-oxidative effects, recent research has demonstrated that molecular hydrogen can serve as a new medical approach for depression, anxiety and traumatic brain injury. However, its potential effects on neurodevelopmental diseases, such as autism are still elusive. The present study aims to investigate the potential effects of hydrogen-rich water (HRW) administratio
Literature Review
MHID-7641248PMID: 296834802018Federation of European Biochemical Societies (FEBS) Letters
Phillip B. Hylemon, Spencer C. Harris, Jason M. Ridlon
The human gut microbiome refers to a highly diverse microbial ecosystem, which has a symbiotic relationship with the host. Molecular hydrogen (H2) and carbon dioxide (CO2) are generated by fermentative metabolism in anaerobic ecosystems. H2 generation and oxidation coupled to CO2 reduction to methane or acetate help maintain the structure of the gut microbiome. Bile acids are synthesized by hepato
Animal StudyIn VitroHighlighted
MHID-4778348PMID: 303151732018Nature Communications
Penghe Zhao, Zhaokui Jin, Qian Chen, Tian Yang, Danyang Chen, Jin Meng, et al.
By delivering the concept of clean hydrogen energy and green catalysis to the biomedical field, engineering of hydrogen-generating nanomaterials for treatment of major diseases holds great promise. Leveraging virtue of versatile abilities of Pd hydride nanomaterials in high/stable hydrogen storage, self-catalytic hydrogenation, near-infrared (NIR) light absorption and photothermal conversion, here
Literature ReviewHighlighted
MHID-7292601PMID: 287518022017Journal of Clinical Biochemistry and Nutrition
Kenji Dohi, Kazue Satoh, Kazuyuki Miyamoto, Shusuke Momma, Kenichiro Fukuda, Ryo Higuchi, et al.
Oxidative stress caused by reactive oxygen species is considered a major mediator of tissue and cell injuries in various neuronal conditions, including neurological emergencies and neurodegenerative diseases. Molecular hydrogen is well characterized as a scavenger of hydroxyl radicals and peroxynitrite. Recently, the neuroprotective effects of treatment with molecular hydrogen have been reported i
In VitroHighlighted
MHID-1014265PMID: 286201982017Scientific Reports
Ching-Ying Wu, Wen-Li Hsu, Ming-Hsien Tsai, Jui-Lin Liang, Jian-He Lu, Chia-Jung Yen, et al.
Based on the oxidative stress theory, aging derives from the accumulation of oxidized proteins induced by reactive oxygen species (ROS) in the cytoplasm. Hydrogen peroxide (H2O2) elicits ROS that induces skin aging through oxidation of proteins, forming disulfide bridges with cysteine or methionine sulfhydryl groups. Decreased Ca2+ signaling is observed in aged cells, probably secondary to the for
MHID-6937869PMID: 311241362017Scientific Reports
Qiang Gao, Han Song, Xiao-ting Wang, Ying Liang, Yan-jie Xi, Yuan Gao, et al.
The inability to successfully adapt to stress produces pathological changes that can lead to depression. Molecular hydrogen has anti-oxidative and anti-inflammatory activities and neuroprotective effects. However, the potential role of molecular hydrogen in stress-related disorders is still poorly understood. The present study aims to investigate the effects of hydrogen gas on resilience to stress
Literature ReviewHighlighted
MHID-2847992PMID: 278264242016Medical Gas Research
Ou-yang Chen, Zhou-heng Ye, Chong Li
June 27, 2015, the Second Hydrogen Molecule Biomedical Symposium and the Second meeting of the Professional Committee of Molecular Hydrogen Biology and Medicine of China Association of Promoting International Communication of health care was grand opening in the Capital of China, Beijing, sponsored by China Association of Promoting International Communication of health care, undertaken by Professi
Literature Review
MHID-0365812PMID: 282172942016Medical Gas Research
Lei Huang
Molecular hydrogen (H2) medicine research has flourished since a landmark publication in Nature Medicine that revealed the antioxidant and cytoprotective effects of hydrogen gas in a focal stroke model. Emerging evidence has consistently demonstrated that molecular hydrogen is a promising therapeutic option for a variety of diseases and the underlying comprehensive mechanisms is beyond pure hydrox
Literature ReviewHighlighted
MHID-7479916PMID: 264839532015Medical Gas Research
Masatoshi Ichihara, Sayaka Sobue, Mikako Ito, Masafumi Ito, Masaaki Hirayama, Kinji Ohno
Therapeutic effects of molecular hydrogen for a wide range of disease models and human diseases have been investigated since 2007. A total of 321 original articles have been published from 2007 to June 2015. Most studies have been conducted in Japan, China, and the USA. About three-quarters of the articles show the effects in mice and rats. The number of clinical trials is increasing every year. I
Opinion Piece
MHID-8567647PMID: 261233972015The Journal of Thoracic and Cardiovascular Surgery
Harold L. Lazar, MD
Patients with pulmonary arterial hypertension (PAH) are at higher risk for morbidity and mortality after all types of cardiac surgical procedures. These patients have higher incidences of hemodynamic instability, hypoxemia, and right ventricular dysfunction. Current therapy for PAH has included prostanoids, endothelial receptor antagonists, and phosphodiesterase inhibitors. Although these agents h
Clinical TrialHighlighted
MHID-29235562014Sports medicine / News in Molecular Hydrogen Biomedicine
Sergej M Ostojic, Boris Vukomanovic, Julio Calleja-Gonzalez, Jay R Hoffman
Background: Because hydrogen therapy has been found beneficial for the treatment of inflammation, ischemia-reperfusion injury, and oxidative stress in humans, it seems useful to evaluate the effects of exogenously administered hydrogen as an element in the immediate management of sports-related soft tissue injuries. The main aim of this pilot study was to examine the effects of 2-week administrati
Animal Study
MHID-0185761PMID: 252512202014PLoS ONE
Kenji Dohi, Brian C. Kraemer, Michelle A. Erickson, Pamela J. McMillan, Andrej Kovac, Zuzana Flachbartova, et al.
Traumatic brain injury (TBI) in its various forms has emerged as a major problem for modern society. Acute TBI can transform into a chronic condition and be a risk factor for neurodegenerative diseases such as Alzheimer’s and Parkinson’s diseases, probably through induction of oxidative stress and neuroinflammation. Here, we examined the ability of the antioxidant molecular hydrogen given in drink
