Literature Review
MHID-1879460PMID: 378931902023Biomedicines
Shin-ichi Hirano, Yusuke Ichikawa, Bunpei Sato, Yoshiyasu Takefuji, Fumitake Satoh
As diabetes rates surge globally, there is a corresponding rise in the number of patients suffering from diabetic kidney disease (DKD), a common complication of diabetes. DKD is a significant contributor to chronic kidney disease, often leading to end-stage renal failure. However, the effectiveness of current medical treatments for DKD leaves much to be desired. Molecular hydrogen (H2) is an antio
In VitroHighlighted
MHID-57291662023Hydrogen
Grace Russell, Adam D. Thomas, Alexander Nenov, Georgia Mannings, John T. Hancock
Cancer is a leading cause of mortality worldwide. B-cells are a keystone of the adaptive immune response and are essential for the presentation of tumor-associated antigens to various types of T-cells. Approximately 1.5% of global cancer cases, including breast and gastric carcinomas and both Hodgkin’s and non-Hodgkin’s lymphomas, are linked with prior Epstein–Barr Virus (EBV) infection. Such prop
Systematic ReviewHighlighted
MHID-32722772023Pharmaceuticals
Nikola Todorovic, Julen Fernández-Landa, Asier Santibañez, Branislav Kura, Valdemar Stajer, Darinka Korovljev, et al.
Over the last two decades, a plethora of disease models and human studies have confirmed the beneficial effects of molecular hydrogen (H2), a simple biotherapeutic gas. Recent small-scale studies evaluating the effects of hydrogen-rich water (HRW) on various metabolic conditions pointed to advantageous effects of HRW in regulating blood lipid profiles. However, to the best of the authors’ knowledge,
Animal StudyHighlighted
MHID-2957577PMID: 381373622023Biomedicines
Tatyana Kuropatkina, Dmitrii Atiakshin, Fedor Sychev, Marina Artemieva, Tatyana Samoilenko, Olga Gerasimova, et al.
Hydrogen has been shown to exhibit selective antioxidant properties against hydroxyl radicals, and exerts antioxidant and anti-inflammatory effects. The monocrotaline-induced model of pulmonary hypertension is suitable for studying substances with antioxidant activity because oxidative stress is induced by monocrotaline.
On day 1, male Wistar rats were subcutaneously injected with a water–alcohol
Clinical TrialHighlighted
MHID-7707676PMID: 375698502023International Journal of Molecular Sciences
Zuzana Sumbalova, Jarmila Kucharská, Zuzana Rausová, Anna Gvozdjakova, Mária Szántová, Branislav Kura, et al.
Molecular hydrogen (H2) has been recognized as a novel medical gas with antioxidant and anti-inflammatory effects. Non-alcoholic fatty liver disease (NAFLD) is a liver pathology with increased fat accumulation in liver tissue caused by factors other than alcohol consumption. Platelet mitochondrial function is considered to reflect systemic mitochondrial health. We studied the ef- fect of adjuvant th
Systematic ReviewHighlighted
MHID-3427886PMID: 373542432023Asian Pacific Journal of Cancer Prevention
Muhammad Nooraiman Zufayri Mohd Noor, Adlin Sofea Alauddin, Yin How Wong, Chung Yeng Looi, Eng Hwa Wong, Priya Madhavan, et al.
Background: Cancer remains a challenging target to cure, with present therapeutic methods unable to exhibit restorative outcomes without causing severe negative effects. Molecular hydrogen (H2) has been reported to be a promising adjunctive therapy for cancer treatment, having the capability to induce anti-proliferative, anti-oxidative, pro-apoptotic and anti-tumoural effects. This review summaris
Animal StudyIn VitroHighlighted
MHID-1279019PMID: 372155682023Theranostics
Geru Tao, Feng Liu, Zhaokui Jin, Boyan Liu, Hao Wang, Daosheng Li, et al.
Background: Chronic liver diseases (CLD) frequently derive from hepatic steatosis, inflammation and fibrosis, and become a leading inducement of cirrhosis and hepatocarcinoma. Molecular hydrogen (H2) is an emerging wide-spectrum anti-inflammatory molecule which is able to improve hepatic inflammation and metabolic dysfunction, and holds obvious advantages in biosafety over traditional anti-CLD dru
Clinical TrialHighlighted
MHID-8082099PMID: 362047842023Medical Gas Research
Anna Vaycheslavovna Deryugina, Darya Andreevna Danilova, Yurii Dmitrievich Brichkin, Evgenii Vladimirovich Taranov, Evgenii Ivanovich Nazarov, Vladimir Viktorovich Pichugin, et al.
Molecular hydrogen (H2) has been considered a preventive and therapeutic medical gas in numerous diseases. The study aimed to investigate the potential role of molecular hydrogen as a component of anesthesia in surgical treatment with cardiopulmonary bypass (CPB) of acquired valve defects on the functional state of red blood cells (RBC) and functional indicators of cardiac activity. This clinical
Clinical TrialIn VitroObservational StudyHighlighted
MHID-30414712023Processes
Richard J. Bloomer, Yufeng Zhang, Joshua Y. Shirazi, Chidimma Okegbe, Jacquelyn Pence, Keith Martin, et al.
Alpha Hope is a dietary supplement containing pyrroloquinoline quinone and elemental magnesium, which produces molecular hydrogen (H2 gas) when dissolved in water. We determined the impact of Alpha Hope on Nrf-2, peroxisome proliferator-activated receptor-gamma coactivator (PGC-1α), and citrate synthase (CS) activity in C2C12 myoblasts. Alpha Hope was titrated to three concentrations of pyrroloqui
Animal StudyHighlighted
MHID-70633602023The Indonesian Biomedical Journal
Lina Hadi, Albert Manggading Hutapea, Florenly
BACKGROUND: Orthodontic tooth movement (OTM) may increase the risk of treatment-related complications for some diabetes mellitus (DM) patients. Hydrogen-rich water (HRW) has been demonstrated in many studies to reduce oxidative stress and cell damage. This study aimed to examine the levels of interleukin (IL)-1β, blood glucose level, body weight, tooth displacement, and population of osteoclasts a
Clinical TrialHighlighted
MHID-6109070PMID: 362356282022Nutrients
Ahad Abdulkarim D. Alharbi, Noriaki Iwamoto, Naoyuki Ebine, Satoshi Nakae, Tatsuya Hojo, Yoshiyuki Fukuoka
This research examined the effects of single-dose molecular hydrogen (H2) supplements on acid-base status and local muscle deoxygenation during rest, high-intensity intermittent training (HIIT) performance, and recovery. Ten healthy, trained subjects in a randomized, double-blind, crossover design received H2-rich calcium powder (HCP) (1500 mg, containing 2.544 µg of H2) or H2-depleted placebo (15
Literature ReviewHypothesisHighlighted
MHID-3205850PMID: 359678412022Frontiers in Cellular and Infection Microbiology
Sergej M Ostojic
The molecular footprints of COVID-19 occur everywhere, even reaching the family of biologically active gases and gasotransmitters. Besides nitric oxide and hydrogen sulfide, COVID-19 might also alter the homeostasis of dihydrogen (H2), another gaseous bioactive molecule produced endogenously by the human gut bacteria. Many studies have shown various alterations of the gut microbiota in patients wit
Clinical TrialHighlighted
MHID-50217702022European Journal of Inflammation
Aleksandra Milovancev, Jovana Avakumovic, Patrik Drid, Nikola Todorovic, Valdemar Stajer, Sergej M Ostojic
Molecular hydrogen (H2) has been recently put forward as a possible adjunct therapeutics in COVID-19 due to its anti-inflammatory and pulmo-protective effects.1,2 An open-label randomized trial in 44 patients with laboratory-confirmed COVID-19 from seven hospitals in China demonstrated that 3-day hydrogen inhalation resulted in significantly more patients with improved disease severity and reduced dy
Clinical TrialHighlighted
MHID-1269854PMID: 362782212022Frontiers in Pharmacology
Boyan Liu, Xue Jiang, Yunbo Xie, Xiubin Jia, Jiashuo Zhang, Yazhuo Xue, et al.
Objective: To explore the effect of a low-dose hydrogen–oxygen (H2-O2) mixture inhalation in midlife/older adults with hypertension.
Methods: This randomized, placebo-controlled trial included 60 participants with hypertension aged 50–70 years who were randomly divided into Air group (inhaled placebo air) or H2-O2 group [inhaled H2-O2 mixture (66% H2/33% O2)]. Participants in both groups were tre
Clinical TrialHighlighted
MHID-82748422022Processes
Mihyun Lee, Ailyn Fadriquela, Jayson M. Antonio, Cheol-Su Kim, Il-Young Cho, Ka-Eun Kim, et al.
Regular physical activity confers health benefits and improves the general quality of life. Recently, alkaline-reduced water (ARW) consumption has garnered increasing attention in the field of sports. ARW effectively inhibits the oxidative stress generated in cells during high-intensity exercises; however, whether it exerts similar effects during exhaustive exercises remains unknown. This study was
Animal StudyIn VitroEx VivoHighlighted
MHID-2989698PMID: 361678142022Nature Communications
Shengqiang Chen, Yanxia Zhu, Qingqing Xu, Qi Jiang, Danyang Chen, Ting Chen, et al.
High-glucose microenvironment in the diabetic foot ulcer (DFU) causes excessive glycation and induces chronic inflammation, leading to the difficulty of DFU healing. Hydrogen-rich water bath can promote the healing of DFU in clinic by virtue of the anti-inflammatory effect of hydrogen molecules, but the long-term daily soaking counts against the formation of a scab and cannot change the high-glucose
In VitroHighlighted
MHID-1024639PMID: 350759432022The International Journal of Artificial Organs
Foivos Leonidas Mouzakis, Lal Babu Khadka, Miguel Pereira da Silva, Khosrow Mottaghy
The prevalence of oxidative and inflammatory stress in end-stage renal disease (ESRD) patients has often been associated with chronic haemodialysis therapies. Over the past decades, several reports have shown the potential of hydrogen molecule as an antioxidant in the treatment of various medical conditions in animal models, as well as in pilot studies with human patients. Recently, a hydrogen-enr
Animal StudyHighlighted
MHID-2919108PMID: 349481072021International Journal of Molecular Sciences
Eun-Sook Jeong, Johny Bajgai, In-Soo You, Md. Habibur Rahman, Ailyn Fadriquela, Subham Sharma, et al.
Oxidative stress (OS) is one of the causative factors in the pathogenesis of various neurode- generative diseases, including Alzheimer’s disease (AD) and cognitive dysfunction. In the present study, we investigated the effects of hydrogen (H2) gas inhalation in trimethyltin (TMT)-induced neurotoxicity and cognitive dysfunction in the C57BL/6 mice. First, mice were divided into the following groups
Observational Study
MHID-82694502021Renal Replacement Therapy
Hidehisa Satta, Tamio Iwamoto, Yuki Kawai, Naoaki Koguchi, Kazuhiko Shibata, Nobuteru Kobayashi, et al.
Background: A novel hemodialysis (HD) system employing electrolyzed water containing molecular hydrogen (E-HD) has been developed to improve the bio-compatibility of HD. This study examined the impact of E-HD on changes in redox state during HD and HD-related fatigue.
Method: This single-arm, prospective observational study examined 63 patients on chronic HD (41 males; mean age, 72 ± 9 years; med
Literature Review
MHID-6029476PMID: 346464232021Oxidative Medicine and Cellular Longevity
Duried Alwazeer, Franky Fuh-Ching Liu, Xiao Yu Wu, Tyler W. LeBaron
COVID-19 is a widespread global pandemic with nearly 185 million confirmed cases and about four million deaths. It is caused by an infection with the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), which primarily affects the alveolar type II pneumocytes. The infection induces pathological responses including increased inflammation, oxidative stress, and apoptosis. This situation result
