Literature Review
MHID-1191317PMID: 406196052025Advanced Science
Gangfeng Li, Hannan Cui, Ruixiao Fan, Guming Liu, Zishuo Hou, Yibo Zhang, et al.
The delivery of molecular hydrogen (H2) is increasingly recognized for its potential in precision immunomodulation, primarily through multiple pathways such as antioxidant action, modulation of inflammatory factors, and inhibition of apoptosis. These effects contribute to a balanced and functional immune system, highlighting the therapeutic promise of H2 in various inflammatory conditions. However, t
MHID-88889642025International Journal of Radiation Oncology Biology Physics
K.M. Mani, C.M. Maruschak, C. Vacchi-Suzzi, H. Munoz, L. Joya, A.N. Slade, et al.
Purpose/Objective(s): Radiation is a mainstay of therapy for head/neck cancer. However, patients invariably develop mucositis along the targeted subsite, which persists during and after treatment, leading to weight loss, hospital admissions and potentially treatment interruptions. Hydrogen-rich water (HRW) is an available supplement that is thought to scavenge free radicals and confer anti-inflamma
Animal StudyHighlighted
MHID-4439338PMID: 401810802025Scientific Reports
Victor Pascal-Moussellard, Jean-Pierre Alcaraz, Stéphane Tanguy, Cordélia Salomez-Ihl, Philippe Cinquin, François Boucher, et al.
Inulin consumption and dihydrogen (H2) administration both exert antitumor effects on preclinical models as well as in clinical trials. As H2 is one of the major byproducts of inulin fermentation by bacterial species of the gut microbiota (GM), we hypothesized that H2 could mediate the antitumor effects of inulin. To provide evidence in favor of this hypothesis, we first determined the pattern of
Animal StudyIn VitroHighlighted
MHID-4061148PMID: 406876592025Translational Andrology and Urology
Qijie Chen, Shaoqing Yu, Yating Pan, Hong Tang, Yang Wang, Ninghan Feng, et al.
Background: Diabetes mellitus (DM) is a chronic metabolic disorder characterized by persistent hyperglycemia, leading to severe systemic complications and reduced quality of life. Current therapies often fail to comprehensively alleviate diabetic complications, highlighting the need for novel approaches. Animal studies and clinical trials have demonstrated the therapeutic potential of molecular hy
Systematic Review
MHID-7472923PMID: 382560452024International Journal of Molecular Sciences
Gagandeep Dhillon, Venkata Buddhavarapu, Harpreet Grewal, Pranjal Sharma, Ram Kishun Verma, Ripudaman Munjal, et al.
Hydrogen-rich water (HRW) has emerged as a novel approach in the field of health and wellness. It is believed to have therapeutic antioxidant properties that can neutralize harmful free radicals in the human body. It has also been shown to be beneficial in mitigating oxidative stress-induced damage through its anti-inflammatory and anti-apoptotic pathways. We aim to conduct a systematic review to
Clinical TrialHighlighted
MHID-6306651PMID: 394936772024OncoTargets and Therapy
Imjai Chitapanarux, Wimrak Onchan, Somvilai Chakrabandhu, Pooriwat Muangwong, Narongchai Autsavapromporn, Tapanut Ariyanon, et al.
Hydrogen (H2) gas inhalation might alleviate acute radiotherapy toxicities by scavenging free radicals produced by ionizing radiation and anti-inflammatory properties. This study aimed to investigate the feasibility and safety of H2 gas inhalation during concurrent chemoradiotherapy (CCRT) in patients with locally advanced head and neck cancer (LAHNC).
Patients and Methods: We designed a pilot pro
Literature ReviewHighlighted
MHID-5381032PMID: 369788842023Antioxidants
Mikhail Yu. Artamonov, Andrew K. Martusevich, Felix A. Pyatakovich, Inessa A. Minenko, Sergei V. Dlin, Tyler W. LeBaron
It is known that molecular hydrogen is a relatively stable, ubiquitous gas that is a minor component of the atmosphere. At the same time, in recent decades molecular hydrogen has been shown to have diverse biological effects. By the end of 2022, more than 2000 articles have been published in the field of hydrogen medicine, many of which are original studies. Despite the existence of several review
Systematic ReviewHighlighted
MHID-3427886PMID: 373542432023Asian Pacific Journal of Cancer Prevention
Muhammad Nooraiman Zufayri Mohd Noor, Adlin Sofea Alauddin, Yin How Wong, Chung Yeng Looi, Eng Hwa Wong, Priya Madhavan, et al.
Background: Cancer remains a challenging target to cure, with present therapeutic methods unable to exhibit restorative outcomes without causing severe negative effects. Molecular hydrogen (H2) has been reported to be a promising adjunctive therapy for cancer treatment, having the capability to induce anti-proliferative, anti-oxidative, pro-apoptotic and anti-tumoural effects. This review summaris
Animal StudyHighlighted
MHID-0513892PMID: 351161142022World Journal of Gastrointestinal Oncology
Fereshteh Asgharzadeh, Alex Tarnava, Asma Mostafapour, Majid Khazaei, Tyler W. LeBaron
Background: Colorectal cancer (CRC) is the third leading cause of cancer-related deaths in the world. Tumor removal remains the preferred frontline treatment; however, effective non-surgical interventions remain a high priority. 5-fluorouracil (5-FU) is a widely used chemotherapy agent, and molecular hydrogen (H2) has been re- cognized for its antioxidant and anti-inflammatory effects, with resear
Observational StudyHighlighted
MHID-8463226PMID: 354337312022Frontiers in Medicine
Xiaofeng Kong, Tianyu Lu, You-Yong Lu, Zhinan Yin, Kecheng Xu
Objective: To evaluate the clinical efficacy and safety of hydrogen inhalation in improving hearing loss in patients with long-term survival of nasopharyngeal carcinoma after radiotherapy.
Methods: The eustachian tube dysfunction score, pure tone air conduction threshold, bone conduction threshold, the score of tympanogram and otoscope were prospectively observed in patients with deafness after ra
In VitroHighlighted
MHID-6868466PMID: 352700302022International Journal of Molecular Sciences
Tomoya Hasegawa, Mikako Ito, Satoru Hasegawa, Masaki Teranishi, Koki Takeda, Shuto Negishi, et al.
Molecular hydrogen ameliorates pathological states in a variety of human diseases, animal models, and cell models, but the effects of hydrogen on cancer have been rarely reported. In addition, the molecular mechanisms underlying the effects of hydrogen remain mostly unelucidated. We found that hydrogen enhances proliferation of four out of seven human cancer cell lines (the responders). The prolif
Literature ReviewHighlighted
MHID-5389125PMID: 344454282021International Journal of Molecular Sciences
Shin-ichi Hirano, Haru Yamamoto, Yusuke Ichikawa, Bunpei Sato, Yoshiyasu Takefuji, Fumitake Satoh
While many antitumor drugs have yielded unsatisfactory therapeutic results, drugs are one of the most prevalent therapeutic measures for the treatment of cancer. The development of cancer largely results from mutations in nuclear DNA, as well as from those in mitochondrial DNA (mtDNA). Molecular hydrogen (H2), an inert molecule, can scavenge hydroxyl radicals (·OH), which are known to be the stron
Observational StudyHighlighted
MHID-7483719PMID: 329948212020Oncology Letters
Junji Akagi, Hideo Baba
As previously reported, hydrogen gas improves the prognosis of patients with cancer by restoring exhausted CD8+ T cells into active CD8+ T cells, possibly by activating mitochondria. As mitochondrial activators exhibit synergistic effects with nivolumab, the current study investigated whether hydrogen gas also affects the clinical outcomes of nivolumab. A total of 42 of 56 patients with lung cance
Literature Review
MHID-23826142019Journal of Nutritional Oncology
Dong Yue Du, Yun Hua Peng, Jian Kang Liu, Jian Gang Long
Molecular hydrogen is an effective antioxidant. Numerous studies have demonstrated the therapeutic effects of hydrogen in the treatment of various human diseases. The possibility of using hydrogen in the treatment of cancer was first discovered in 1975, and in recent studies, researchers have reported numerous positive effects of hydrogen in cancer therapy, including: 1) the alleviation of complic
Observational Study
MHID-0991273PMID: 315528732019Medical Gas Research
Ji-Bing Chen, Xiao-Feng Kong, You-Yong Lv, Shu-Cun Qin, Xue-Jun Sun, Feng Mu, et al.
Advanced cancer treatment is a huge challenge and new ideas and strategies are required. Hydrogen exerts antioxidant and anti-inflammatory effects that may be exploited to control cancer, the occurrence and progression of which is closely related to peroxidation and inflammation. We conducted a prospective follow-up study of 82 patients with stage III and IV cancer treated with hydrogen inhalation
Animal StudyIn VitroHighlighted
MHID-18249022018Translational Cancer Research
Lei Shang, Fei Xie, Jiala Li, Yating Zhang, Mengyu Liu, Pengxiang Zhao, et al.
Background: To investigate the potential effects of molecular hydrogen on ovarian cancer.
Methods: The in vivo study was performed using Hs38.T xenografted BALB/c nude mice. The mean tumor volume was monitored during 6 weeks of hydrogen inhalation. Immunohistochemistry (IHC) staining was performed to determine the Ki67 and CD34 expression. The in vitro effects of molecular hydrogen on proliferati
Animal StudyIn VitroHighlighted
MHID-4778348PMID: 303151732018Nature Communications
Penghe Zhao, Zhaokui Jin, Qian Chen, Tian Yang, Danyang Chen, Jin Meng, et al.
By delivering the concept of clean hydrogen energy and green catalysis to the biomedical field, engineering of hydrogen-generating nanomaterials for treatment of major diseases holds great promise. Leveraging virtue of versatile abilities of Pd hydride nanomaterials in high/stable hydrogen storage, self-catalytic hydrogenation, near-infrared (NIR) light absorption and photothermal conversion, here
Literature Review
MHID-5774686PMID: 301278612018Oncology Letters
Ye Yang, Yaping Zhu, Xiaowei Xi
Hydrogen (H2) has advantages that lead it to be
used as a novel antioxidant in preventive and therapeutic
applications. H2 can permeate into biomembranes, cytosol,
mitochondria and nuclei, and can be dissolved in water or
saline to produce H2 water or H2‑rich saline. H2 selectively
reduces oxidants of the detrimental reactive oxygen species
(ROS), including hydroxyl radicals (·OH) and peroxynitrit
Animal StudyIn VitroHighlighted
MHID-8667127PMID: 277892932016Free Radical Biology and Medicine
Takafumi Ushida, Tomomi Kotani, Hiroyuki Tsuda, Kenji Imai, Tomoko Nakano, Shima Hirako, et al.
Oxidative stress plays an important role in the pathogenesis of preeclampsia. Recently, molecular hydrogen (H2) has been shown to have therapeutic potential in various oxidative stress-related diseases. The aim of this study is to investigate the effect of H2 on preeclampsia. We used the reduced utero-placental perfusion pressure (RUPP) rat model, which has been widely used as a model of preeclamps
Literature ReviewHighlighted
MHID-7479916PMID: 264839532015Medical Gas Research
Masatoshi Ichihara, Sayaka Sobue, Mikako Ito, Masafumi Ito, Masaaki Hirayama, Kinji Ohno
Therapeutic effects of molecular hydrogen for a wide range of disease models and human diseases have been investigated since 2007. A total of 321 original articles have been published from 2007 to June 2015. Most studies have been conducted in Japan, China, and the USA. About three-quarters of the articles show the effects in mice and rats. The number of clinical trials is increasing every year. I
