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Literature Review

Anti‑inflammatory and antitumor action of hydrogen via reactive oxygen species

MHID-5774686PMID: 301278612018Oncology Letters

Ye Yang, Yaping Zhu, Xiaowei Xi

Hydrogen (H2) has advantages that lead it to be used as a novel antioxidant in preventive and therapeutic applications. H2 can permeate into biomembranes, cytosol, mitochondria and nuclei, and can be dissolved in water or saline to produce H2 water or H2‑rich saline. H2 selectively reduces oxidants of the detrimental reactive oxygen species (ROS), including hydroxyl radicals (·OH) and peroxynitrit

Animal StudyHighlighted

Hydrogen-Rich Water and Lactulose Protect Against Growth Suppression and Oxidative Stress in Female Piglets Fed Fusarium Toxins Contaminated Diets

MHID-6423123PMID: 298670312018Toxins

Weijiang Zheng, Xu Ji, Qing Zhang, Wenchao Du, Quanwei Wei, Wen Yao

The objective of the current experiment was to evaluate whether hydrogen-rich water (HRW) or lactulose (LAC) could protect against the adverse effects of Fusarium mycotoxins-contaminated diet on the growth performance and antioxidant status in weaning piglets. A total of 24 individually housed female piglets were randomly assigned to receive four treatments for 25 days (six pigs/treatment): uncont

Clinical TrialHighlighted

Daily ingestion of alkaline electrolyzed water containing hydrogen influences human health, including gastrointestinal symptoms

MHID-6786572PMID: 307136692018Medical Gas Research

Yoshinori Tanaka, Yasuhiro Saihara, Kyoko Izumotani, Hajime Nakamura

In Japan, alkaline electrolyzed water (AEW) apparatus have been approved as a medical device. And for the patients with gastrointestinal symptoms, drinking AEW has been found to be effective in relieving gastrointestinal symptoms. But some users of AEW apparatus do not have abdominal indefinite complaint. Little attention has been given to the benefit for the users which have no abdominal indefini

Clinical TrialAnimal StudyHighlighted

Effects of Molecular Hydrogen Assessed by an Animal Model and a Randomized Clinical Study on Mild Cognitive Impairment

MHID-5385411PMID: 291106152018Current Alzheimer Research

Kiyomi Nishimaki, Takashi Asada, Ikuroh Ohsawa, Etsuko Nakajima, Chiaki Ikejima, Takashi Yokota, et al.

Background: Oxidative stress is one of the causative factors in the pathogenesis of neurodegenerative diseases including mild cognitive impairment (MCI) and dementia. We previously reported that molecular hydrogen (H2) acts as a therapeutic and preventive antioxidant. Objective: We assess the effects of drinking H2-water (water infused with H2) on oxidative stress model mice and subjects with MCI