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Clinical Trial

Hydrogen‑rich water reduces inflammatory responses and prevents apoptosis of peripheral blood cells in healthy adults: a randomized, double‑blind, controlled trial

MHID-9025289PMID: 326992872020Scientific Reports

Minju Sim, Chong‑Su Kim, Woo‑Jeong Shon, Young‑Kwan Lee, Eun Young Choi, Dong‑Mi Shin

The evidence for the beneficial effects of drinking hydrogen-water (HW) is rare. We aimed to investigate the effects of HW consumption on oxidative stress and immune functions in healthy adults using systemic approaches of biochemical, cellular, and molecular nutrition. In a randomized, double-blind, placebo-controlled study, healthy adults (20–59 y) consumed either 1.5 L/d of HW (n = 20) or plain

Literature ReviewHypothesis

A “philosophical molecule,” hydrogen may overcome senescence and intractable diseases

MHID-1633113PMID: 321896692020Medical Gas Research

Shin-ichi Hirano, Yusuke Ichikawa, Ryosuke Kurokawa, Yoshiyasu Takefuji, Fumitake Satoh

It has been revealed that the cause of senescence and diseases is associated with the reactive oxygen species “hydroxyl radicals” (·OH). Se- nescence and diseases may be overcome as long as we can scavenge •OH mostly produced in mitochondria. It is one and only one “molecular hydrogen” (H2) that can both penetrate into the mitochondria and scavenge the •OH. The H2 in the body can function in disea

Animal StudyHighlighted

Effects of long‑term hydrogen intervention on the physiological function of rats

MHID-8428241PMID: 331161632020Scientific Reports

Zhi‑ming Xun, Qing‑hui Zhao, Yan Zhang, Fang‑di Ju, Jin He, Ting‑ting Yao, et al.

The potential therapeutic effects of molecular hydrogen (H2) have now been confirmed in various human and animal-disease models. However, the effects of H2 on the physiological function in a normal state have been largely neglected. Hydrogen-rich water (HRW) intake and hydrogen inhalation (HI) are the most common used methods for hydrogen administration, the difference in the effects between HRW i

Literature Review

Molecular hydrogen: A potential radioprotective agent

MHID-3062702PMID: 327638202020Biomedicine & Pharmacotherapy

Qiongge Hu, Yunxiang Zhou, Shijie Wu, Wei Wu, Yongchuan Deng, Anwen Shao

In recent years, many studies have shown that hydrogen has therapeutic and preventive effects on various diseases. Its selective antioxidant properties were well noticed. Most of the ionizing radiation-induced damage is caused by hydroxyl radicals (.OH) from radiolysis of H2O . Since hydrogen can mitigate such damage through multiple mechanisms, it presents noteworthy potential as a novel radio-pro