Chemical/Physicochemical Study
MHID-03629032024Molecular Hydrogen in Health and Disease
Katarína Valachová, Branislav Kura, Jan Slezak, Mojmír Mach, Ladislav Šoltés
Molecular hydrogen is well-known for its antioxidative and antiinflammatory properties in numerous in vitro and in vivo experiments. High-molar-mass hyaluronan (HMM HA), a natural polysaccharide present in tissues of all vertebrates, was used as a marker of the polysaccharide degradation by reactive oxygen species. The radical scavenging capacity of various sources of molecular hydrogen dissolved
Chemical/Physicochemical StudyHighlighted
MHID-12000302024Water
Nikolay Vassilev, Ignat Ignatov, Teodora P. Popova, Fabio Huether, Alexander I. Ignatov, Mario T. Iliev, et al.
The present study investigated the 1H Nuclear Magnetic Resonance (NMR) spectra of hydrogen-rich water (HRW) produced using the EVObooster device. The analyzed HRW has pH = 7.1 ± 0.11, oxidation–reduction potential (ORP) of (−450 ± 11) mV, and a dissolved hydrogen concentration of 1.2 ppm. The control sample was tap water filtered by patented technology. A 600 NMR spectrometer was used to measure N
Chemical/Physicochemical StudyHypothesisHighlighted
MHID-10655712023Aging Pathobiology and Therapeutics
Shigeo Ohta
Oxidative stress is one of the major causes of most age-dependent neurodegenerative disorders. Neurons accumulate oxidative damage over time due to post-mitotic cells. Thus, modulation of oxidative stress is essential to overcome these disorders. Molecular hydrogen (H2) has great potential for treating various diseases and improving quality of life by exerting multiple functions including anti-oxi
Animal StudyChemical/Physicochemical StudyHighlighted
MHID-2226442PMID: 374635172023Canadian Journal of Physiology and Pharmacology
Barbora Kalocayova, Branislav Kura, Jana Vlkovicova, Denisa Snurikova, Norbert Vrbjar, Karel Frimmel, et al.
Cardiac surgery-associated acute kidney injury (CS-AKI) is a common postoperative complication, mostly due to increasing oxidative stress. Recently, molecular hydrogen (H2 gas), has also been applied to cardiac surgery due to its ability to reduce oxidative stress. We evaluated the potential effect of H2 application on the kidney in an in vivo model of simulated heart transplantation. Pigs underwe
Chemical/Physicochemical StudyHighlighted
MHID-3839513PMID: 361933472022Journal of Food Science and Technology
Duried Alwazeer, Nur Özkan
Strawberries are known for their high perishability and short shelf life. The effects of incorporating hydrogen gas into sealed packaging on the quality and shelf life of strawberries were evaluated. Fruits were packaged under reducing atmosphere [RAP1 (5% CO2, 4% H2, 91% N2) and RAP2 (10% CO2, 4% H2, 86% N2)], modified atmosphere [MAP1 (5% CO2, 95% N2) and MAP2 (10% CO2, 90% N2)], and control, fol
Chemical/Physicochemical Study
MHID-8624125PMID: 363515042022International Journal of Pharmaceutics
Hennie Marie Johnsen, Werner Filtvedt, Marianne Hiorth, Jo Klaveness
Medical use of hydrogen gas (H2) has been given increasing attention over the past 15 years with numerous
clinical trials for a variety of indications. The biological activity of H2 includes antioxidant properties and
thereby the ability to neutralize damaging reactive oxygen species (ROS). Administration of hydrogen as a
medical gas is limited by the poor water solubility and by the flammability
In VitroChemical/Physicochemical StudyHighlighted
MHID-6183029PMID: 267392572016Scientific Reports
Katsuya Iuchi, Akemi Imoto, Naomi Kamimura, Kiyomi Nishimaki, Harumi Ichimiya, Takashi Yokota, et al.
We previously showed that H2 acts as a novel antioxidant to protect cells against oxidative stress. Subsequently, numerous studies have indicated the potential applications of H2 in therapeutic and preventive medicine. Moreover, H2 regulates various signal transduction pathways and the expression of many genes. However, the primary targets of H2 in the signal transduction pathways are unknown. Her
Chemical/Physicochemical Study
MHID-6682168PMID: 250864382014Free Radical Biology and Medicine
Jelle Penders, Reinhard Kissner, Willem H. Koppenol
H2 has been suggested to act as an antioxidant when administered just before the reperfusion phase of induced oxidative stress. These effects have been reported, for example, for the heart, brain, and liver. It is hypothesized that this beneficial effect may be due to selective scavenging of HO⋅ and ONOOH by H2. The reaction of H2 with HO⋅ has been studied by pulse radiolysis in the past and is too
