Observational StudyHighlighted
MHID-67657942026medRxiv
Yuusuke Harada, Michiko Miyakawa
Background: Falls among older adults are a leading cause of fractures, loss of independence, and need for long-term care. Community salons in Japan promote social participation and health activities among older adults. Hydrogen-rich water is widely used as a health product, but evidence in community settings remains limited.
Methods: We conducted a prospective observational study among 48 communit
Clinical TrialAnimal StudyHighlighted
MHID-05612832025Sportivnaya meditsina: nauka i praktika (Sports medicine: research and practice)
Oleg S. Medvedev, Aleksey A. Uzhakov, Olga L. Konnova, Oxana V. Povarova
Purpose of the study: to investigate the effect of periodic hydrogen inhalations for one month on the main performance characteristics, lactate levels and other biochemical parameters determined in the blood of young wrestlers after physical activity.
Materials and methods. 10 healthy volunteer athletes took part in a prospective clinical study. The analysis of hydrogen and methane levels in exha
Observational Study
MHID-31585802025Sport Sciences for Health
Nikola Todorovic, Jovan Kuzmanovic, Dejan Javorac, Sergej M Ostojic
Purpose Exercise induces transient physiological disruptions, including immune suppression and gastrointestinal (GI) disturbance. Molecular hydrogen (H₂), an endogenously produced gas with antioxidant and anti-inflammatory properties, may play a protective role in this context. While the therapeutic potential of exogenous H₂ has been widely explored, little is known about endogenous hydrogen respo
Clinical TrialHighlighted
MHID-96660182025Journal of Physical Education and Sport
Jakub Krejčí, Michal Botek, Shigeo Ohta, Klara Botkova, Andrew McKune
Problem Statement: Effective inter-match recovery plays a crucial role in preserving performance and preventing injuries in well-trained soccer players. In this context, molecular hydrogen has attracted increasing attention in sports science due to its selective antioxidative, anti-inflammatory, and cell-signaling properties that may facilitate recovery. Among the various administration methods, h
Observational StudyHighlighted
MHID-2151796PMID: 399341432025Scientific Reports
Masaaki Nakayama, Kimio Watanabe, Emiko Sato, Yugo Ito, Nozomi Kadota, Kasumi Konishi, et al.
Hemodialysis employing molecular hydrogen (H2)-enriched dialysis solution rendered by water electrolysis (E-HD), has been reported to alleviate dialysis-related fatigue, but its association with metabolic profiles remains unclear. Eighty-one patients undergoing standard HD were classified into 3 groups [Group A (n = 25, 30.9%): fatigue with activity reduction—subgroups A1: chronic persistent fatig
Clinical TrialObservational StudyHighlighted
MHID-1241888PMID: 400777852025Nutrients
Inna Misnikova, Yulia Kovaleva, Svetlana Shokur, Tyler W. LeBaron, Oxana Povarova, Oleg Medvedev
Background: The aim of this study was to investigate the relationship between postprandial glycemic levels based on flashmonitoring and the production of intestinal hydrogen (H2) and methane (CH4) gases based on the measurement of the amount of these gases in exhaled air. Materials and Methods: We studied 14 subjects with type 2 diabetes mellitus (T2DM) and 14 individuals without diabetes (control
Clinical TrialHighlighted
MHID-8924760PMID: 408680532025Biomedicines
Takafumi Maruyama, Dai Ishikawa, Rina Kurokawa, Hiroaki Masuoka, Kei Nomura, Mayuko Haraikawa, et al.
Background/Objective: Dysbiosis is implicated in the pathogenesis of ulcerative colitis. Hydrogen has been reported to promote intestinal microbiota diversity and suppress ulcerative colitis progression in mice models. In this study, we investigated changes in the intestinal microbiota, therapeutic effects, and safety of hydrogen inhalation in patients with ulcerative colitis.
Methods: In this ra
Clinical TrialHighlighted
MHID-5491717PMID: 412043202025Trials
Victoria Habet, Tysen DeWaard, Krislyn M. Boggs, Alix Fetch, Bao Nguyen Puente, Lynn A. Sleeper, et al.
Background: Extracorporeal cardiopulmonary resuscitation (ECPR) improves survival for patients experiencing refractory cardiac arrest but is often associated with severe ischemia-reperfusion injury (IRI). Hydrogen gas (H2) has demonstrated promising preclinical efficacy in reducing IRI. The Hydrogen-FAST trial investigates the feasibility and safety of inhaled hydrogen gas as an adjunctive therapy
Clinical TrialHighlighted
MHID-9166764PMID: 408269302025Medical Gas Research
Yu Hong Gao, Jun Chen, Hua Zhong, Qiang Zhao
Sleep disorders are associated with various chronic diseases. While hydrogen has anti-inflammatory, antioxidant, and antifibrotic effects and has potential applications in disease management, its impact on sleep disorders remains unclear. This single-blind, randomized controlled clinical trial from September 2022 to July 2023 at the Second Medical Center of the PLA General Hospital and the Affilia
Literature ReviewObservational StudyHighlighted
MHID-3682903PMID: 411676902025IN VIVO
YOU‐CHI REN, JENG‐WEI LU, YI‐JUNG HO, SHAN‐WEN LUI, TING‐YU HSIEH, KUANG‐YIH WANG, et al.
Background/Aim: Rheumatoid arthritis (RA) is a chronic autoimmune disease affecting synovial joints, often causing
to joint destruction and systemic comorbidities. Cervical spine involvement, especially atlantoaxial subluxation (AAS),
can lead to spinal cord compression and neurological deficits. While disease‑modifying antirheumatic drugs (DMARDs)
are standard therapy, intolerance to agents like
Clinical TrialHighlighted
MHID-1036598PMID: 399231332025Medical Gas Research
Pavel Grepl, Michal Botek, Jakub Krejčí, Andrew McKune
Initially, molecular hydrogen was considered a physiologically inert and non-functional gas. However, experimental and clinical studies have shown that molecular hydrogen has anti-inflammatory, anti-apoptotic, and strong selective antioxidant effects. This study aimed to evaluate the effects of 60 minutes of molecular hydrogen inhalation on respiratory gas analysis parameters using a randomized, d
Clinical Trial
MHID-98854012024Science & Sports
S.H. Ryu, J.H. Oh, K.W. Noh, S. Park
Summary
Objective: This study aimed to contribute towards improving athletic performance by comparing the effects of highly concentrated hydrogen intake before and during exercise on soccer players’ metabolic and athletic performance.
Materials and methods: This study followed a single-blind crossover design involving 10 male college soccer players. Before this experiment, the Vmax measurement a
Human StudyHighlighted
MHID-3244978PMID: 396343822024Acute Medicine & Surgery
Masato Tsuchikane, Takeshi Yamagiwa, Tadaaki Takada, Shinjiro Wakai, Sadaki Inokuchi
A 62-year-old woman was diagnosed with postoperative breast cancer recurrence. While inhaling hydrogen gas through a nasal cannula at home, she used a heat-therapy machine that emitted electromagnetic waves to the breast cancer site. She suddenly experienced explosive sounds in her chest and smelled burning. Subsequently, she experienced several overlapping hemoptysis episodes and was referred to
Clinical Trial
MHID-8109346PMID: 390647852024Nutrients
Gengxin Dong, Haiyan Liu, Yunji Chen, Dapeng Bao, Wentao Xu, Junhong Zhou
Background: The diversity of blood biomarkers used to assess the metabolic mechanisms of hydrogen limits a comprehensive understanding of its effects on improving exercise performance. This study evaluated the impact of hydrogen-rich gas (HRG) on metabolites following sprint-interval exercise using metabolomics approaches, aiming to elucidate its underlying mechanisms of action.
Methods: Ten heal
Clinical Trial
MHID-7502024PMID: 414014412024Canadian Journal of Physiology and Pharmacology
Pavel Grepl, Jakub Krejčí, Andrew McKune, Michal Botek
Molecular hydrogen has gained attention for its potential antioxidant, anti-inflammatory, and ergogenic effects. However, its impact on blood oxygen saturation and autonomic cardiac regulation under resting conditions remains unclear. This randomized, double-blind, placebo-controlled crossover study investigated the effects of a 60-minute molecular hydrogen inhalation on oxygen saturation and hear
Clinical Trial
MHID-0740382PMID: 386986242024International Journal of Sports Medicine
Gengxin Dong, Jianxin Wu, Yinglu Hong, Qian Li, Meng Liu, Guole Jiang, et al.
Hydrogen, as an antioxidant, may have the potential to mitigate fatigue and improve selected oxidative stress markers induced by strenuous exercise. This study focused on a previously unexplored approach involving pre-exercise inhalation of hydrogen-rich gas (HRG). Twenty-four healthy adult men first completed pre-laboratories to determine maximum cycling power (Wmax) and maximum cycling time (Tma
Clinical TrialHighlighted
MHID-9198954PMID: 397039112024PeerJ
Yuqi Zhao, Chaoqun Li, Shi Zhou, Zhiguang Xu, Xin Huang, Li Wen
Background: Inhalation of hydrogen gas (H2) as an antioxidant supplement may alleviate exercise-induced oxidative damage and protect post-exercise hydrogen peroxide signaling, which may help mediate beneficial exercise adaptation. The aims of this study were to determine the effects of H2 inhalation on plasma nitric oxide (NO) level and its synthesis precursor in professional athletes.
Methods: A
Observational StudyHighlighted
MHID-3946150PMID: 393102562024International Journal of Medical Sciences
Kuo-Cheng Lu, Min-Chung Shen, Reui-Lin Wang, Wen-Wen Chen, Szu-Han Chiu, Yung-His Kao, et al.
Background: Persistent inflammation over time can cause gradual harm to the body. Molecular hydrogen has the potential to specifically counteract reactive oxygen species (ROS), reduce disease severity, and enhance overall health. Investigations of the anti-inflammatory and antioxidant properties of oral solid hydrogen capsules (OSHCs) are currently limited, prompting our examination of the benefic
Clinical TrialHighlighted
MHID-1852029PMID: 385323732024BMC Women's Health
Menekşe Nazlı Aker, İlknur M. Gönenç, Dilan Çalişici, Menekşe Bulut, Duried Alwazeer, Tyler W. LeBaron
Background Premenstrual syndrome (PMS) consists of psychiatric or somatic symptoms negatively affecting the daily life. PMS treatment can involve the use of complementary-alternative approaches. Hydrogen-rich water (HRW) has antioxidant and anti-inflammatory properties that may treat PMS. This study aimed to investigate the effect of drinking HRW on the severity of premenstrual symptoms and the q
Clinical Trial
MHID-14786562024Current Developments in Nutrition
Sonja Baltic, Nikola Todorovic, Marijana Ranisavljev, Dragana Zanini, David Nedeljkovic, Darinka Korovljev, et al.
Objectives: Molecular hydrogen (H2) and pyrroloquinoline quinone (PQQ) have been suggested to activate metabolic pathways associated with cognition. No human studies have assessed the efficacy of this nutritional combination in the clinical context of mild cognitive impairment (MCI). The primary objective of this randomized placebo-controlled trial was to evaluate the effects of a six-week suppleme
