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Systematic ReviewMeta-Analysis

Can molecular hydrogen supplementation reduce exercise-induced oxidative stress in healthy adults? A systematic review and meta-analysis

MHID-0733746PMID: 385908282024Frontiers in Nutrition

Yiting Li, Renjie Bing, Meng Liu, Zhangyuting Shang, Yan Huang, Kaixiang Zhou, et al.

Objective: Exercise-induced oxidative stress affects multiple neurophysiological processes, diminishing the exercise performance. Hydrogen (H2) can selectively reduce excessive free radicals, but studies observed its “dual effects” on exercise-induced oxidative stress, that is, increasing or decreasing the oxidative stress. Therefore, we here conducted a systematic review and meta-analysis to quan

Meta-AnalysisHighlighted

The Effects of Hydrogen-Rich Water on Blood Lipid Profiles in Metabolic Disorders Clinical Trials: A Systematic Review and Meta-analysis

MHID-22939332024International Journal of Endocrinology and Metabolism

Hamid Jamialahmadi, Ghazaleh Khalili-Tanha, Mostafa Rezaei-Tavirani, Elham Nazari

Context: Metabolic disorders are a growing global concern, especially in developed countries, due to their increasing prevalence. Serum lipid profiles, including triglycerides (TG), total cholesterol (TC), high-density lipoprotein (HDL), and low-density lipoprotein (LDL), are commonly used clinical biomarkers for monitoring the progression of these metabolic abnormalities. In recent decades, hydro

Meta-AnalysisHypothesisHighlighted

The impact of hydrogen-rich water on liver enzyme levels in clinical populations: a comprehensive review and meta-analysis

MHID-1049920PMID: 404064272024Gastroenterology and Hepatology From Bed to Bench

Ghazaleh Khalili-Tanha, Hamid Jamialahmadi, Mostafa Rezaei-Tavirani, Elham Nazari

Aim: This systematic review and meta-analysis aimed to assess the effect of hydrogen-rich water (HRW) on liver enzyme levels. Background: Liver disease is a significant global health concern, greatly affecting mortality rates. Elevated levels of liver enzymes, such as ALT, AST, ALP, and GGT are early symptoms of liver disorders, and various approaches can help reduce them. Recent studies have sho

Systematic ReviewMeta-AnalysisHighlighted

Anti-inflammatory and antioxidant activity of high concentrations of hydrogen in the lung diseases: a systematic review and meta-analysis

MHID-4133017PMID: 392110452024Frontiers in Immunology

Kang Xiao, Jianwei Liu, Yuxin Sun, Shangya Chen, Jiazi Ma, Mao Cao, et al.

As a small molecule, hydrogen is colorless, odorless and lightest. Many studies conducted that hydrogen can protect almost every organ, including the brain, heart muscle, liver, small intestine, and lungs. To verify whether high concentrations of hydrogen (HCH) has anti-inflammatory and antioxidant activities on respiratory system, we product a systematic review and meta- analysis. We investigated

Meta-AnalysisHighlighted

Effects of molecular hydrogen supplementation on fatigue and aerobic capacity in healthy adults: A systematic review and meta-analysis.

MHID-3941772PMID: 368196972023Frontiers in nutrition

Kaixiang Zhou, Liu M, Wang Y, Liu H, Manor B, Bao D, et al.

Background: Fatigue is oftentimes induced by high-intensity exercise potentially via the exceeded amount of reactive oxygen species, leading to diminished functions (e.g., aerobic capacity) and increased risk of injuries. Studies indicate that molecular hydrogen (H2), with antioxidant and anti-inflammatory properties, may be a promising strategy to alleviate fatigue and improve aerobic capacity. H

Systematic ReviewMeta-AnalysisHighlighted

Effects of hydrogen rich water and pure water on periodontal inflammatory factor level, oxidative stress level and oral flora: a systematic review and meta-analysis

MHID-6169739PMID: 363888302022Annals of Translational Medicine

Yang Bai, Chenglong Wang, Hua Jiang, Lin Wang, Nan Li, Wei Zhang, et al.

Background: Hydrogen rich water (HRW) was used as an auxiliary treatment for periodontitis and peri-implantitis due to its good antioxidant properties. However, the stability of artificially added active hydrogen was far less than that of pure natural active hydrogen, which greatly reduced active hydrogen molecules number in HRW. Meanwhile, the effect of HRW was relatively slow. Finally, long-term

Literature ReviewMeta-Analysis

Prospects of molecular hydrogen in perioperative neuroprotection from basic research to clinical application

MHID-7985788PMID: 328266282020Current Opinion in Anesthesiology

Zhen Wang, Guolin Wang, Keliang Xie

Purpose of review: The current systematic review summarizes recent, basic clinical achievements regarding the neuroprotective effects of molecular hydrogen in distinct central nervous system conditions. Recent findings: Perioperative neuroprotection remains a major topic of clinical anesthesia. Various gaseous molecules have previously been explored as a feasible therapeutic option in neurologica